Towards Argument-Driven Validation of an in silico Model of Immune Tissue Organogenesis

  • Kieran Alden
  • Paul S. Andrews
  • Jon Timmis
  • Henrique Veiga-Fernandes
  • Mark Coles
Part of the Lecture Notes in Computer Science book series (LNCS, volume 6825)


Specialised tissues of the immune system including lymph nodes, tonsils, spleen and Peyer’s Patches have key roles in the initiation of adaptive immune responses to infection. To understand the molecular mechanisms involved in the development of this tissue, mice deficient for key genes in this process have been developed and analysed, leading to a basic model describing tissue formation. Although this approach has provided some key insights into the molecular mechanisms involved, due to the complexity of gene expression patterns it has not been possible to fully understand the process of lymphoid tissue organogenesis.


Experimental Autoimmune Encephalomyelitis Domain Model Platform Model Biological Expert Peyers Patch 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Kieran Alden
    • 1
    • 2
  • Paul S. Andrews
    • 2
  • Jon Timmis
    • 2
    • 3
  • Henrique Veiga-Fernandes
    • 4
  • Mark Coles
    • 1
  1. 1.Centre for Immunology and Infection, Hull York Medical School and Department of BiologyUniversity of YorkUK
  2. 2.Department of Computer ScienceUniversity of YorkUK
  3. 3.Department of ElectronicsUniversity of YorkHeslingtonUK
  4. 4.Immunology Unit, Institute of Molecular MedicineUniversity of LisbonPortugal

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