The Value of Inflammatory Signals in Adaptive Immune Responses

  • Soumya Banerjee
  • Drew Levin
  • Melanie Moses
  • Frederick Koster
  • Stephanie Forrest
Part of the Lecture Notes in Computer Science book series (LNCS, volume 6825)


Cells of the immune system search among billions of healthy cells to find and neutralize a small number of infected cells before pathogens replicate to sufficient numbers to cause disease or death. The immune system uses information signals to accomplish this search quickly. Ordinary differential equations and spatially explicit agent-based models are used to quantify how capillary inflammation decreases the time it takes for cytotoxic T lymphocytes to find and kill infected cells. We find that the inflammation signal localized in a small region of infected tissue dramatically reduces search times, suggesting that these signals play an important role in the immune response, especially in larger animals.


Infected Cell Adaptive Immune Response Mouse Lung Chemokine Gradient Infected Region 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Soumya Banerjee
    • 1
  • Drew Levin
    • 1
  • Melanie Moses
    • 1
  • Frederick Koster
    • 2
  • Stephanie Forrest
    • 1
  1. 1.Department of Computer ScienceUniversity of New MexicoUSA
  2. 2.Department of PathologyUniversity of New MexicoUSA

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