Dynamic Model of the dLGN Push-Pull Circuitry
In the present work we propose a dynamic model of the lateral geniculate nucleus (dLGN) that allows the implementation of different configurations of the push-pull circuitry in order to study the spatio-temporal filtering being carried out. It is widely accepted that each relay neuron receives only one input from a single retinal ganglion cell, which leads to interpret that the thalamus preserves the retinal structure of the receptive field and thus works as a simple relay station. We believe that this assumption is not fully valid and the thalamus could perform a more relevant processing of information through its complex push-pull circuitry. To test this hypothesis, a computational model was developed with a wiring configuration (convergence/divergence) between the retina and the dLGN based on experimental evidences, and a realistic description of the ON and OFF channels of dLGN. We found that this configuration may help improve the contrast of a stimulus by increasing its synaptic weight on higher frequencies.
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- 1.Madarász, M., Gerle, J., Hajdu, F., Somogyi, G., Tómból, T.: Quantitative histological studies on the lateral geniculate nucleus in the cat. II. Cell numbers and densities in the several layers. J. Hirnforsch 19(2), 159–164 (1978)Google Scholar
- 3.Yeh, C.I., Stoelzel, C.R., Weng, C., Alonso, J.M.: Functional Consequences of Neural Divergence Within the Retinogeniculate Pathway. J. Neurophysiol. 101 (2009)Google Scholar
- 4.Alonso, J.M., Yeh, C.I., Weng, C., Stoelzel, C.: Retinogeniculate connections: a balancing act between connection specificity and receptive field diversity. Progress in Brain Research 154 (2006)Google Scholar
- 5.Allen, E.A., Freeman, R.D.: Dynamic Spatial Processing Originates in Early Visual Pathways (2006)Google Scholar
- 8.McCormick, D.A., Huguenard, J.: A model of the electrophysiological properties of thalamocortical relay neurons. Journal of Neurophysiology 68, 1384–1400 (1992)Google Scholar
- 9.Huguenard, J.R., McCormick, D.A.: Voltage clamp simulations of currents involved in rhythmic oscillations in thalamic relay neurones. Journal of Neurophysiology 68, 1373–1383 (1992)Google Scholar
- 10.Palmer, S.E.: Vision Science. MIT, Cambridge (1999)Google Scholar
- 13.Koch, C.: Biophysics of Computation. Oxford University Press, Oxford (1999)Google Scholar
- 14.Manzón, M.M., Rodríguez, M.M., Otero, L.M.: DEA. How the thalamus chages What the cat′s eye tells the cat′s brain (2009)Google Scholar