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Anode Make and Break Excitation Mechanisms and Strength-Interval Curves: Bidomain Simulations in 3D Rotational Anisotropy

  • Piero Colli-Franzone
  • Luca F. Pavarino
  • Simone Scacchi
Part of the Lecture Notes in Computer Science book series (LNCS, volume 6666)

Abstract

The shape of anodal strength-interval curves and make and break excitation mechanisms are investigated in a 2D anisotropic Bidomain model, with different membrane models and action potential durations, and in a 3D rotational anisotropic Bidomain model, with axisymmetric or orthotropic conductivity properties. The results have shown that the LRd model with a long intrinsic APD exhibits a systolic dip threshold lower than the diastolic threshold, in agreement with previous experimental data. The spatial and temporal analysis of the excitation patterns indicates a novel anode make excitation mechanism with delayed propagation within the transition from break to make mechanisms.

Keywords

Action Potential Duration Excitation Pattern Stimulation Amplitude Break Excitation Bidomain Model 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Piero Colli-Franzone
    • 1
  • Luca F. Pavarino
    • 2
  • Simone Scacchi
    • 2
  1. 1.Dipartimento di MatematicaUniversità di Pavia and IMATI-CNR, Istituto di Matematica Applicata e Tecnologie InformatichePaviaItaly
  2. 2.Dipartimento di MatematicaUniversità di MilanoMilanoItaly

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