Building a GATK-Based Tool for Methylation Analysis in Next-Generation Bisulfite Sequencing Experiments
Bisulfite sequencing is a technique that can be combined with next-generation sequencing approaches to analyze DNA methylation patterns in a genome wide scale. The GATK framework is a new Java framework for fast-developing NGS applications including capabilities for automatic shared-memory parallelization. This work presents the design and initial performance results of a methylation caller for next-generation bisultife sequencing based on the GATK framework.
KeywordsDNA methylation next-generation sequencing bisulfite sequencing GATK
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