Mechanics and Regulation of Cell Shape During the Cell Cycle

Chapter

Abstract

Many cell types undergo dramatic changes in shape throughout the cell cycle. For individual cells, a tight control of cell shape is crucial during cell division, but also in interphase, for example during cell migration. Moreover, cell cycle-related cell shape changes have been shown to be important for tissue morphogenesis in a number of developmental contexts. Cell shape is the physical result of cellular mechanical properties and of the forces exerted on the cell. An understanding of the causes and repercussions of cell shape changes thus requires knowledge of both the molecular regulation of cellular mechanics and how specific changes in cell mechanics in turn effect global shape changes. In this chapter, we provide an overview of the current knowledge on the control of cell morphology, both in terms of general cell mechanics and specifically during the cell cycle.

References

  1. Aigouy B, Farhadifar R, Staple DB, Sagner A, Röper JC, Jülicher F, Eaton S (2010) Cell flow reorients the axis of planar polarity in the wing epithelium of Drosophila. Cell 142:773–786PubMedGoogle Scholar
  2. Arber S, Barbayannis FA, Hanser H, Schneider C, Stanyon CA, Bernard O, Caroni P (1998) Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase. Nature 393:805–809PubMedGoogle Scholar
  3. Arcuri F, Papa S, Meini A, Carducci A, Romagnoli R, Bianchi L, Riparbelli MG, Sanchez J-C, Palmi M, Tosi P, Cintorino M (2005) The translationally controlled tumor protein is a novel calcium binding protein of the human placenta and regulates calcium handling in trophoblast cells. Biol Reprod 73:745–751PubMedGoogle Scholar
  4. Azoury J, Lee KW, Georget V, Rassinier P, Leader B, Verlhac MH (2008) Spindle positioning in mouse oocytes relies on a dynamic meshwork of actin filaments. Curr Biol 18:1514–1519PubMedGoogle Scholar
  5. Baena-López LA, Baonza A, García-Bellido A (2005) The orientation of cell divisions determines the shape of Drosophila organs. Curr Biol 15:1640–1644PubMedGoogle Scholar
  6. Baker J, Garrod D (1993) Epithelial cells retain junctions during mitosis. J Cell Sci 104:415–425PubMedGoogle Scholar
  7. Bamburg JR, McGough A, Ono S (1999) Putting a new twist on actin: ADF/cofilins modulate actin dynamics. Trends Cell Biol 9:364–370PubMedGoogle Scholar
  8. Barros CS, Phelps CB, Brand AH (2003) Drosophila nonmuscle myosin II promotes the asymmetric segregation of cell fate determinants by cortical exclusion rather than active transport. Dev Cell 5:829–840PubMedGoogle Scholar
  9. Bazile F, Pascal A, Arnal I, Le Clainche C, Chesnel F, Kubiak JZ (2009) Complex relationship between TCTP, microtubules and actin microfilaments regulates cell shape in normal and cancer cells. Carcinogenesis 30:555–565PubMedCentralPubMedGoogle Scholar
  10. Bereiter-Hahn J (2005) Mechanics of crawling cells. Med Eng Phys 27:743–753PubMedGoogle Scholar
  11. Bereiter-Hahn J, Anderson OR, Reif WE (1987) Cytomechanics. The mechanical basis of cell form and structure. Springer, Berlin, GermanyGoogle Scholar
  12. Berlin RD, Oliver JM (1980) Surface functions during mitosis. II. Quantitation of pinocytosis and kinetic characterization of the mitotic cycle with a new fluorescence technique. J Cell Biol 85:660–671PubMedGoogle Scholar
  13. Berlin RD, Oliver JM, Walter RJ (1978) Surface functions during mitosis I: phagocytosis, pinocytosis and mobility of surface-bound ConA. Cell 15:327–341PubMedGoogle Scholar
  14. Bhatt AS, Erdjument-Bromage H, Tempst P, Craik CS, Moasser MM (2005) Adhesion signaling by a novel mitotic substrate of src kinases. Oncogene 24:5333–5343PubMedCentralPubMedGoogle Scholar
  15. Bittig T, Wartlick O, González-Gaitán M, Jülicher F (2009) Quantification of growth asymmetries in developing epithelia. Eur Phys J E 30:93–99PubMedGoogle Scholar
  16. Blanchard GB, Kabla AJ, Schultz NL, Butler LC, Sanson B, Gorfinkiel N, Mahadevan L, Adams RJ (2009) Tissue tectonics: morphogenetic strain rates, cell shape change and intercalation. Nat Methods 6:458–464PubMedGoogle Scholar
  17. Blot J, Chartrain I, Roghi C, Philippe M, Tassan J-P (2002) Cell cycle regulation of pEg3, a new Xenopus protein kinase of the KIN1/PAR-1/MARK family. Dev Biol 241:327–338PubMedGoogle Scholar
  18. Bluemink JG, de Laat SW (1973) New membrane formation during cytokinesis in normal and cytochalasin B-treated eggs of Xenopus laevis. J Cell Biol 59:89–108PubMedGoogle Scholar
  19. Boal D (2002) Mechanics of the cell. Cambridge University Press, Cambridge, UKGoogle Scholar
  20. Borghi N, Nelson WJ (2009) Intercellular adhesion in morphogenesis: molecular and biophysical considerations. Curr Top Dev Biol 89:1–32PubMedGoogle Scholar
  21. Bos JL (2005) Linking rap to cell adhesion. Curr Opin Cell Biol 17:123–128PubMedGoogle Scholar
  22. Boucrot E, Kirchhausen T (2007) Endosomal recycling controls plasma membrane area during mitosis. Proc Natl Acad Sci USA 104:7939–7944PubMedGoogle Scholar
  23. Boucrot E, Kirchhausen T (2008) Mammalian cells change volume during mitosis. PLoS One 3:e1477PubMedCentralPubMedGoogle Scholar
  24. Bradley R, Woods A, Carruthers L, Rees D (1980) Cytoskeleton changes in fibroblast adhesion and detachment. J Cell Sci 43:379–390Google Scholar
  25. Bray D, White JG (1988) Cortical flow in animal cells. Science 239:883–888PubMedGoogle Scholar
  26. Bretscher A, Edwards K, Fehon RG (2002) ERM proteins and merlin: integrators at the cell cortex. Nat Rev Mol Cell Biol 3:586–599PubMedGoogle Scholar
  27. Bringmann H, Hyman AA (2005) A cytokinesis furrow is positioned by two consecutive signals. Nature 436:731–734PubMedGoogle Scholar
  28. Britch M, Allen TD (1980) The modulation of cellular contractility and adhesion by trypsin and EGTA. Exp Cell Res 125:221–231PubMedGoogle Scholar
  29. Brochard-Wyart F, Borghi N, Cuvelier D, Nassoy P (2006) Hydrodynamic narrowing of tubes extruded from cells. Proc Natl Acad Sci USA 103:7660–7663PubMedGoogle Scholar
  30. Brodland GW, Conte V, Cranston PG, Veldhuis J, Narasimhan S, Hutson MS, Jacinto A, Ulrich F, Baum B, Miodownik M (2010) Video force microscopy reveals the mechanics of ventral furrow invagination in Drosophila. Proc Natl Acad Sci USA 107:22111–22116Google Scholar
  31. Brown MJ, Hallam JA, Colucci-Guyon E, Shaw S (2001) Rigidity of circulating lymphocytes is primarily conferred by vimentin intermediate filaments. J Immunol 166:6640–6646PubMedGoogle Scholar
  32. Burgess DR, Chang F (2005) Site selection for the cleavage furrow at cytokinesis. Trends Cell Biol 15:156–162PubMedGoogle Scholar
  33. Burgess RW, Deitcher DL, Schwarz TL (1997) The synaptic protein Syntaxin1 is required for cellularization of Drosophila embryos. J Cell Biol 138:861–875PubMedGoogle Scholar
  34. Butler LC, Blanchard GB, Kabla AJ, Lawrence NJ, Welchman DP, Mahadevan L, Adams RJ, Sanson B (2009) Cell shape changes indicate a role for extrinsic tensile forces in Drosophila germ-band extension. Nat Cell Biol 11:859–864PubMedGoogle Scholar
  35. Cabernard C, Prehoda KE, Doe CQ (2010) A spindle-independent cleavage furrow positioning pathway. Nature 467:91–94PubMedGoogle Scholar
  36. Caille N, Thoumine O, Tardy Y, Meister J-J (2002) Contribution of the nucleus to the mechanical properties of endothelial cells. J Biomech 35:177–187PubMedGoogle Scholar
  37. Cao LG, Wang YL (1990b) Mechanism of the formation of contractile ring in dividing cultured animal cells. I. Recruitment of preexisting actin filaments into the cleavage furrow. J Cell Biol 110:1089–1095PubMedGoogle Scholar
  38. Cao LG, Wang YL (1990a) Mechanism of the formation of contractile ring in dividing cultured animal cells. II. Cortical movement of microinjected actin filaments. J Cell Biol 111:1905–1911PubMedGoogle Scholar
  39. Carlsson AE (2003) Growth velocities of branched actin networks. Biophys J 84:2907–2918PubMedCentralPubMedGoogle Scholar
  40. Carreno S, Kouranti I, Glusman ES, Fuller MT, Echard A, Payre F (2008) Moesin and its activating kinase Slik are required for cortical stability and microtubule organization in mitotic cells. J Cell Biol 180:739–746PubMedGoogle Scholar
  41. Chackalaparampil I, Shalloway D (1988) Altered phosphorylation and activation of PP60c-src during fibroblast mitosis. Cell 52:801–810PubMedGoogle Scholar
  42. Charras G, Paluch E (2008) Blebs lead the way: how to migrate without lamellipodia. Nat Rev Mol Cell Biol 9:730–736PubMedGoogle Scholar
  43. Charras GT, Yarrow JC, Horton MA, Mahadevan L, Mitchison TJ (2005) Non-equilibration of hydrostatic pressure in blebbing cells. Nature 435:365–369PubMedCentralPubMedGoogle Scholar
  44. Charras GT, Coughlin M, Mitchison TJ, Mahadevan L (2008) Life and times of a cellular bleb. Biophys J 94:1836–1853PubMedCentralPubMedGoogle Scholar
  45. Chartrain I, Couturier A, Tassan J-P (2006) Cell-cycle-dependent cortical localization of pEg3 protein kinase in Xenopus and human cells. Biol Cell 98:253–263PubMedGoogle Scholar
  46. Cheng NN, Kirby CM, Kemphues KJ (1995) Control of cleavage spindle orientation in Caenorhabditis elegans: the role of the genes par-2 and par-3. Genetics 139:549–559PubMedGoogle Scholar
  47. Chew T-L, Masaracchia RA, Goeckeler ZM, Wysolmerski RB (1998) Phosphorylation of non-muscle myosin II regulatory light chain by p21-activated kinase (γ-PAK). J Muscle Res Cell Motil 19:839–854PubMedGoogle Scholar
  48. Chou YH, Bischoff JR, Beach D, Goldman RD (1990) Intermediate filament reorganization during mitosis is mediated by p34cdc2 phosphorylation of vimentin. Cell 62:1063–1071PubMedGoogle Scholar
  49. Chu YS, Dufour S, Thiery JP, Perez E, Pincet F (2005) Johnson-Kendall-Roberts theory applied to living cells. Phys Rev Lett 94:028102PubMedGoogle Scholar
  50. Concha ML, Adams RJ (1998) Oriented cell divisions and cellular morphogenesis in the zebrafish gastrula and neurula: a time-lapse analysis. Development 125:983–994PubMedGoogle Scholar
  51. Coniglio SJ, Zavarella S, Symons MH (2008) Pak1 and Pak2 mediate tumor cell invasion through distinct signaling mechanisms. Mol Cell Biol 28:4162–4172PubMedCentralPubMedGoogle Scholar
  52. Cramer LP, Mitchison TJ (1997) Investigation of the mechanism of retraction of the cell margin and rearward flow of nodules during mitotic cell rounding. Mol Biol Cell 8:109–119PubMedCentralPubMedGoogle Scholar
  53. Cui C, Yang X, Chuai M, Glazier JA, Weijer CJ (2005) Analysis of tissue flow patterns during primitive streak formation in the chick embryo. Dev Biol 284:37–47PubMedGoogle Scholar
  54. Cunningham CC, Gorlin JB, Kwiatkowski DJ, Hartwig JH, Janmey PA, Byers R, Stossel TP (1992) Actin-binding protein requirement for cortical stability and efficient locomotion. Science 255:325–327PubMedGoogle Scholar
  55. Cuvelier D, Théry M, Chu Y-S, Dufour S, Thiéry J-P, Bornens M, Nassoy P, Mahadevan L (2007) The universal dynamics of cell spreading. Curr Biol 17:694–699PubMedGoogle Scholar
  56. Dai J, Ting-Beall HP, Hochmuth RM, Sheetz MP, Titus MA (1999) Myosin I contributes to the generation of resting cortical tension. Biophys J 77:1168–1176PubMedCentralPubMedGoogle Scholar
  57. Dao VT, Dupuy AG, Gavet O, Caron E, de Gunzburg J (2009) Dynamic changes in Rap1 activity are required for cell retraction and spreading during mitosis. J Cell Sci 122:2996–3004PubMedGoogle Scholar
  58. David-Pfeuty T, Nouvian-Dooghe Y (1990) Immunolocalization of the cellular src protein in interphase and mitotic NIH c-src overexpresser cells. J Cell Biol 111:3097–3116PubMedGoogle Scholar
  59. Davidson L, von Dassow M, Zhou J (2009) Multi-scale mechanics from molecules to morphogenesis. Int J Biochem Cell Biol 41:2147–2162PubMedCentralPubMedGoogle Scholar
  60. Dayel MJ, Akin O, Landeryou M, Risca V, Mogilner A, Mullins RD (2009) In silico reconstitution of actin-based symmetry breaking and motility. PLoS Biol 7:e1000201PubMedCentralPubMedGoogle Scholar
  61. DeBiasio RL, LaRocca GM, Post PL, Taylor DL (1996) Myosin II transport, organization, and phosphorylation: evidence for cortical flow/solation-contraction coupling during cytokinesis and cell locomotion. Mol Biol Cell 7:1259–1282PubMedCentralPubMedGoogle Scholar
  62. DiMilla PA, Barbee K, Lauffenburger DA (1991) Mathematical model for the effects of adhesion and mechanics on cell migration speed. Biophys J 60:15–37PubMedCentralPubMedGoogle Scholar
  63. Dinarina A, Pugieux C, Corral MM, Loose M, Spatz J, Karsenti E, Nédélec F (2009) Chromatin shapes the mitotic spindle. Cell 138:502–513PubMedGoogle Scholar
  64. Diz-Muñoz A, Krieg M, Bergert M, Ibarlucea-Benitez I, Muller DJ, Paluch E, Heisenberg CP (2010) Control of directed cell migration in vivo by membrane-to-cortex attachment. PLoS Biol 8:e1000544Google Scholar
  65. Drewes G, Ebneth A, Preuss U, Mandelkow E-M, Mandelkow E (1997) MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. Cell 89:297–308PubMedGoogle Scholar
  66. Effler JC, Kee Y-S, Berk JM, Tran MN, Iglesias PA, Robinson DN (2006) Mitosis-specific mechanosensing and contractile-protein redistribution control cell shape. Curr Biol 16:1962–1967PubMedCentralPubMedGoogle Scholar
  67. Eppinga RD, Li Y, Lin JL-C, Mak AS, Lin JJ-C (2006) Requirement of reversible caldesmon phosphorylation at P21-activated kinase-responsive sites for lamellipodia extensions during cell migration. Cell Motil Cytoskeleton 63:543–562PubMedGoogle Scholar
  68. Erickson CA, Trinkaus JP (1976) Microvilli and blebs as sources of reserve surface membrane during cell spreading. Exp Cell Res 99:375–384PubMedGoogle Scholar
  69. Estecha A, Sánchez-Martín L, Puig-Kröger A, Bartolomé RA, Teixidó J, Samaniego R, Sánchez-Mateos P (2009) Moesin orchestrates cortical polarity of melanoma tumour cells to initiate 3D invasion. J Cell Sci 122:3492–3501PubMedGoogle Scholar
  70. Evans E, Yeung A (1989) Apparent viscosity and cortical tension of blood granulocytes determined by micropipet aspiration. Biophys J 56:151–160PubMedCentralPubMedGoogle Scholar
  71. Fackler OT, Grosse R (2008) Cell motility through plasma membrane blebbing. J Cell Biol 181:879–884PubMedGoogle Scholar
  72. Farhadifar R, Röper J-C, Aigouy B, Eaton S, Jülicher F (2007) The influence of cell mechanics, cell-cell interactions, and proliferation on epithelial packing. Curr Biol 17:2095–2104PubMedGoogle Scholar
  73. Fehon RG, McClatchey AI, Bretscher A (2010) Organizing the cell cortex: the role of ERM proteins. Nat Rev Mol Cell Biol 11:276–287PubMedCentralPubMedGoogle Scholar
  74. Fink J, Carpi N, Betz T, Bétard A, Chebah M, Azioune A, Bornens M, Sykes C, Fetler L, Cuvelier D, Piel M (2011) External forces control mitotic spindle positioning. Nat Cell Biol (in press)Google Scholar
  75. Fishkind D, Wang YL (1993) Orientation and three-dimensional organization of actin filaments in dividing cultured cells. J Cell Biol 123:837–848PubMedGoogle Scholar
  76. Fishkind D, Cao L, Wang YL (1991) Microinjection of the catalytic fragment of myosin light chain kinase into dividing cells: effects on mitosis and cytokinesis. J Cell Biol 114:967–975PubMedGoogle Scholar
  77. Flemming W (1895) Zur Mechanik der Zelltheilung. Archiv für Mikroscopische Anatomie und Entwicklungsmechanik 46:696–701Google Scholar
  78. Folkman J, Moscona A (1978) Role of cell shape in growth control. Nature 273:345–349PubMedGoogle Scholar
  79. Foster DB, Shen L-H, Kelly J, Thibault P, Van Eyk JE, Mak AS (2000) Phosphorylation of Caldesmon by p21-activated kinase. J Biol Chem 275:1959–1965PubMedGoogle Scholar
  80. Fujibuchi T, Abe Y, Takeuchi T, Imai Y, Kamei Y, Murase R, Ueda N, Shigemoto K, Yamamoto H, Kito K (2005) AIP1/WDR1 supports mitotic cell rounding. Biochem Biophys Res Commun 327:268–275PubMedGoogle Scholar
  81. Gauthier NC, Rossier OM, Mathur A, Hone JC, Sheetz MP (2009) Plasma membrane area increases with spread area by exocytosis of a GPI-anchored protein compartment. Mol Biol Cell 20:3261–3272PubMedCentralPubMedGoogle Scholar
  82. Gavet O, Pines J (2010) Progressive activation of CyclinB1-Cdk1 coordinates entry to mitosis. Dev Cell 18:533–543PubMedCentralPubMedGoogle Scholar
  83. Geldmacher-Voss B, Reugels AM, Pauls S, Campos-Ortega JA (2003) A 90˚ rotation of the mitotic spindle changes the orientation of mitoses of zebrafish neuroepithelial cells. Development 130:3767–3780PubMedGoogle Scholar
  84. Giet O, Van Bockstaele DR, Di Stefano I, Huygen S, Greimers R, Beguin Y, Gothot A (2002) Increased binding and defective migration across fibronectin of cycling hematopoietic progenitor cells. Blood 99:2023–2031PubMedGoogle Scholar
  85. Glotzer M (2001) Animal cell cytokinesis. Annu Rev Cell Dev Biol 17:351–386PubMedGoogle Scholar
  86. Glotzer M (2004) Cleavage furrow positioning. J Cell Biol 164:347–351PubMedGoogle Scholar
  87. Gong Y, Mo C, Fraser SE (2004) Planar cell polarity signalling controls cell division orientation during zebrafish gastrulation. Nature 430:689–693PubMedGoogle Scholar
  88. Gorfinkiel N, Blanchard GB, Adams RJ, Martinez Arias A (2009) Mechanical control of global cell behaviour during dorsal closure in Drosophila. Development 136:1889–1898PubMedGoogle Scholar
  89. Goss JW, Toomre DK (2008) Both daughter cells traffic and exocytose membrane at the cleavage furrow during mammalian cytokinesis. J Cell Biol 181:1047–1054PubMedGoogle Scholar
  90. Gotz M, Huttner WB (2005) The cell biology of neurogenesis. Nat Rev Mol Cell Biol 6:777–788PubMedGoogle Scholar
  91. Graham JM, Sumner MCB, Curtis DH, Pasternak CA (1973) Sequence of events in plasma membrane assembly during the cell cycle. Nature 246:291–295PubMedGoogle Scholar
  92. Gray D, Plusa B, Piotrowska K, Na J, Tom B, Glover DM, Zernicka-Goetz M (2004) First cleavage of the mouse embryo responds to change in egg shape at fertilization. Curr Biol 14:397–405PubMedGoogle Scholar
  93. Habela CW, Sontheimer H (2007) Cytoplasmic volume condensation is and integral part of mitosis. Cell Cycle 6:1613–1620PubMedCentralPubMedGoogle Scholar
  94. Hanakam F, Albrecht R, Eckerskorn C, Matzner M, Gerisch G (1996) Myristoylated and non-myristoylated forms of the pH sensor protein hisactophilin II: intracellular shuttling to plasma membrane and nucleus monitored in real time by a fusion with green fluorescent protein. EMBO J 15:2935–2943PubMedGoogle Scholar
  95. Hara K (1971) Cinematographic observation of “surface contraction waves” (SCW) during the early cleavage of axolotl eggs. Dev Genes Evol 167:183–186Google Scholar
  96. Hara K, Tydeman P, Kirschner M (1980) A cytoplasmic clock with the same period as the division cycle in Xenopus eggs. Proc Natl Acad Sci USA 77:462–466PubMedGoogle Scholar
  97. Haubensak W, Attardo A, Denk W, Huttner WB (2004) Neurons arise in the basal neuroepithelium of the early mammalian telencephalon: a major site of neurogenesis. Proc Natl Acad Sci USA 101:3196–3201PubMedGoogle Scholar
  98. Henderson D, Rohrschneider L (1987) Cytoskeletal association of pp 60src: the transforming protein of the rous sarcoma virus. Exp Cell Res 168:411–421PubMedGoogle Scholar
  99. Hertzler PL, Clark WH Jr (1992) Cleavage and gastrulation in the shrimp Sicyonia ingentis: invagination is accompanied by oriented cell division. Development 116:127–140PubMedGoogle Scholar
  100. Hilgenfeldt S, Erisken S, Carthew RW (2008) Physical modeling of cell geometric order in an epithelial tissue. Proc Natl Acad Sci USA 105:907–911PubMedGoogle Scholar
  101. Hiramoto Y (1957) The thickness of the cortex and the refractive index of the protoplasm in Sea urchin eggs. Embryologia 3:361–374Google Scholar
  102. Hochmuth RM (2000) Micropipette aspiration of living cells. J Biomech 33:15–22PubMedGoogle Scholar
  103. Hoffman BD, Crocker JC (2009) Cell mechanics: dissecting the physical responses of cells to force. Annu Rev Biomed Eng 11:259–288PubMedGoogle Scholar
  104. Hotulainen P, Paunola E, Vartiainen MK, Lappalainen P (2005) Actin-depolymerizing factor and Cofilin-1 play overlapping roles in promoting rapid F-actin depolymerization in mammalian nonmuscle cells. Mol Biol Cell 16:649–664PubMedCentralPubMedGoogle Scholar
  105. Hufnagel L, Teleman AA, Rouault H, Cohen SM, Shraiman BI (2007) On the mechanism of wing size determination in fly development. Proc Natl Acad Sci USA 104:3835–3840PubMedGoogle Scholar
  106. Hutson MS, Tokutake Y, Chang MS, Bloor JW, Venakides S, Kiehart DP, Edwards GS (2003) Forces for morphogenesis investigated with laser microsurgery and quantitative modeling. Science 300:145–149PubMedGoogle Scholar
  107. Ingber DE (1993) The riddle of morphogenesis: a question of solution chemistry or molecular cell engineering? Cell 75:1249–1252PubMedGoogle Scholar
  108. Ingber DE (2003) Tensegrity I. Cell structure and hierarchical systems biology. J Cell Sci 116:1157–1173PubMedGoogle Scholar
  109. Iwamoto H, Nakamuta M, Tada S, Sugimoto R, Enjoji M, Nawata H (2000) A p160ROCK-specific inhibitor, Y-27632, attenuates rat hepatic stellate cell growth. J Hepatol 32:762–770PubMedGoogle Scholar
  110. Iwasaki T, Shinkai K, Mukai M, Yoshioka K, Fujii Y, Nakahara K, Matsuda H, Akedo H (1995) Cell-cycle-dependent invasion in vitro by rat ascites hepatoma cells. Int J Cancer 63:282–287PubMedGoogle Scholar
  111. Jaffe AB, Hall A (2005) Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol 21:247–269PubMedGoogle Scholar
  112. Janmey PA, McCulloch CA (2007) Cell mechanics: integrating cell responses to mechanical stimuli. Annu Rev Biomed Eng 9:1–34PubMedGoogle Scholar
  113. Janoueix-Lerosey I, Fontenay M, Tobelem G, Tavitian A, Polakis P, Degunzburg J (1994) Phosphorylation of Rap1GAP during the cell cycle. Biochem Biophys Res Commun 202:967–975PubMedGoogle Scholar
  114. Janson ME, Loughlin R, Loïodice I, Fu C, Brunner D, Nédélec FJ, Tran PT (2007) Crosslinkers and motors organize dynamic microtubules to form stable bipolar arrays in fission yeast. Cell 128:357–368PubMedGoogle Scholar
  115. Käfer J, Hayashi T, Marée AFM, Carthew RW, Graner F (2007) Cell adhesion and cortex contractility determine cell patterning in the Drosophila retina. Proc Natl Acad Sci USA 104:18549–18554PubMedGoogle Scholar
  116. Kaji N, Muramoto A, Mizuno K (2008) LIM kinase-mediated Cofilin phosphorylation during mitosis is required for precise spindle positioning. J Biol Chem 283:4983–4992PubMedGoogle Scholar
  117. Kamasaki T, Osumi M, Mabuchi I (2007) Three-dimensional arrangement of F-actin in the contractile ring of fission yeast. J Cell Biol 178:765–771PubMedGoogle Scholar
  118. Keren K, Pincus Z, Allen GM, Barnhart EL, Marriott G, Mogilner A, Theriot JA (2008) Mechanism of shape determination in motile cells. Nature 453:475–480PubMedCentralPubMedGoogle Scholar
  119. Kimmel CB, Warga RM, Kane DA (1994) Cell cycles and clonal strings during formation of the zebrafish central nervous system. Development 120:265–276PubMedGoogle Scholar
  120. Kimura K, Ito M, Amano M, Chihara K, Fukata Y, Nakafuku M, Yamamori B, Feng J, Nakano T, Okawa K, Iwamatsu A, Kaibuchi K (1996) Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-Kinase). Science 273:245–248PubMedGoogle Scholar
  121. King JS, Veltman DM, Georigiou M, Baum B, Insall RH (2010) SCAR/WAVE is activated at mitosis and drives myosin-independent cytokinesis. J Cell Sci 123:2246–2255PubMedGoogle Scholar
  122. Kiosses WB, Daniels RH, Otey C, Bokoch GM, Schwartz MA (1999) A role for P21-activated kinase in endothelial cell migration. J Cell Biol 147:831–844PubMedGoogle Scholar
  123. Knutton S, Sumner MC, Pasternak CA (1975) Role of microvilli in surface changes of synchronized P815Y mastocytoma cells. J Cell Biol 66:568–576PubMedGoogle Scholar
  124. Krieg M, Arboleda-Estudillo Y, Puech PH, Kafer J, Graner F, Muller DJ, Heisenberg CP (2008a) Tensile forces govern germ-layer organization in zebrafish. Nat Cell Biol 10:429–436PubMedGoogle Scholar
  125. Krieg M, Helenius J, Heisenberg CP, Muller DJ (2008b) A bond for a lifetime: employing membrane nanotubes from living cells to determine receptor-ligand kinetics. Angew Chem Int Ed Engl 47:9775–9777PubMedGoogle Scholar
  126. Kruse K, Joanny J-F, Jülicher F, Prost J, Sekimoto K (2004) Asters, vortices, and rotating spirals in active gels of polar filaments. Phys Rev Lett 92:078101PubMedGoogle Scholar
  127. Kruse K, Joanny J-F, Jülicher F, Prost J, Sekimoto K (2005) Generic theory of active polar gels: a paradigm for cytoskeletal dynamics. Eur Phys J E 16:5–16PubMedGoogle Scholar
  128. Kunda P, Pelling AE, Liu T, Baum B (2008) Moesin controls cortical rigidity, cell rounding, and spindle morphogenesis during mitosis. Curr Biol 18:91–101PubMedGoogle Scholar
  129. Lamb NJC, Fernandez A, Watrin A, Labbé J-C, Cavadore J-C (1990) Microinjection of p34cdc2 kinase induces marked changes in cell shape, cytoskeletal organization, and chromatin structure in mammalian fibroblasts. Cell 60:151–165PubMedGoogle Scholar
  130. Landsberg KP, Farhadifar R, Ranft J, Umetsu D, Widmann TJ, Bittig T, Said A, Jülicher F, Dahmann C (2009) Increased cell bond tension governs cell sorting at the Drosophila anteroposterior compartment boundary. Curr Biol 19:1950–1955PubMedGoogle Scholar
  131. Lecuit T, Lenne P-F (2007) Cell surface mechanics and the control of cell shape, tissue patterns and morphogenesis. Nat Rev Mol Cell Biol 8:633–644PubMedGoogle Scholar
  132. Levi M, Maro B, Shalgi R (2010) The involvement of Fyn kinase in resumption of the first meiotic division in mouse oocytes. Cell Cycle 9:1577–1589PubMedGoogle Scholar
  133. Lipowsky R, Sackmann E (1995) Structure and dynamics of membranes. Handbook of biological physics. Elsevier, Amsterdam, The NetherlandsGoogle Scholar
  134. Liu XH, Wang X (2004) The deformation of an adherent leukocyte under steady shear flow: a numerical study. J Biomech 37:1079–1085PubMedGoogle Scholar
  135. Lomakina EB, Spillmann CM, King MR, Waugh RE (2004) Rheological analysis and measurement of neutrophil indentation. Biophys J 87:4246–4258PubMedCentralPubMedGoogle Scholar
  136. Lu B, Roegiers F, Jan LY, Jan YN (2001) Adherens junctions inhibit asymmetric division in the Drosophila epithelium. Nature 409:522–525PubMedGoogle Scholar
  137. Ma Q, Geng Y, Xu W, Wu Y, He F, Shu W, Huang M, Du H, Li M (2009) The role of translationally controlled tumor protein in tumor growth and metastasis of colon adenocarcinoma cells. J Proteome Res 9:40–49Google Scholar
  138. Mabuchi I, Tsukita S, Sawai T (1988) Cleavage furrow isolated from newt eggs: contraction, organization of the actin filaments, and protein components of the furrow. Proc Natl Acad Sci USA 85:5966–5970PubMedGoogle Scholar
  139. Maddox AS, Burridge K (2003) RhoA is required for cortical retraction and rigidity during mitotic cell rounding. J Cell Biol 160:255–265PubMedGoogle Scholar
  140. Maroto B, Ye MB, von Lohneysen K, Schnelzer A, Knaus UG (2008) P21-activated kinase is required for mitotic progression and regulates Plk1. Oncogene 27:4900–4908PubMedGoogle Scholar
  141. Matzke R, Jacobson K, Radmacher M (2001) Direct, high-resolution measurement of furrow stiffening during division of adherent cells. Nat Cell Biol 3:607–610PubMedGoogle Scholar
  142. Maugis B, Brugués J, Nassoy P, Guillen N, Sens P, Amblard F (2010) Dynamic instability of the intracellular pressure drives bleb-based motility. J Cell Sci 123:3884–3892PubMedGoogle Scholar
  143. Maupin P, Pollard TD (1986) Arrangement of actin filaments and myosin-like filaments in the contractile ring and of actin-like filaments in the mitotic spindle of dividing HeLa cells. J Ultrastruct Mol Struct Res 94:92–103PubMedGoogle Scholar
  144. Mayer M, Depken M, Bois JS, Jülicher F, Grill SW (2010) Anisotropies in cortical tension reveal the physical basis of cortical flow in polarising C. elegans zygotes. Nature 467:617–621PubMedGoogle Scholar
  145. Mitchison JM, Swann MM (1954) The mechanical properties of the cell surface. I. The cell elastimeter. J Exp Biol 31:443–460Google Scholar
  146. Mitchison TJ (1992) Actin based motility on retraction fibers in mitotic PtK2 cells. Cell Motil Cytoskeleton 22:135–151PubMedGoogle Scholar
  147. Mitchison TJ, Charras GT, Mahadevan L (2008) Implications of a poroelastic cytoplasm for the dynamics of animal cell shape. Semin Cell Dev Biol 19:215–223PubMedGoogle Scholar
  148. Mitsushima M, Aoki K, Ebisuya M, Matsumura S, Yamamoto T, Matsuda M, Toyoshima F, Nishida E (2010) Revolving movement of a dynamic cluster of actin filaments during mitosis. J Cell Biol 191:453–462PubMedGoogle Scholar
  149. Miyata T, Kawaguchi A, Saito K, Kawano M, Muto T, Ogawa M (2004) Asymmetric production of surface-dividing and non-surface-dividing cortical progenitor cells. Development 131:3133–3145PubMedGoogle Scholar
  150. Montell DJ (2008) Morphogenetic cell movements: diversity from modular mechanical properties. Science 322:1502–1505PubMedGoogle Scholar
  151. Moon A, Drubin DG (1995) The ADF/Cofilin proteins: stimulus-responsive modulators of actin dynamics. Mol Biol Cell 6:1423–1431PubMedCentralPubMedGoogle Scholar
  152. Morone N, Fujiwara T, Murase K, Kasai RS, Ike H, Yuasa S, Usukura J, Kusumi A (2006) Three-dimensional reconstruction of the membrane skeleton at the plasma membrane interface by electron tomography. J Cell Biol 174:851–862PubMedGoogle Scholar
  153. Mukhina S, Wang YL, Murata-Hori M (2007) Alpha-actinin is required for tightly regulated remodeling of the actin cortical network during cytokinesis. Dev Cell 13:554–565PubMedCentralPubMedGoogle Scholar
  154. Nagasaki A, Kanada M, Uyeda TQP (2009) Cell adhesion molecules regulate contractile ring-independent cytokinesis in Dictyostelium discoideum. Cell Res 19:236–246PubMedGoogle Scholar
  155. Nambiar R, McConnell RE, Tyska MJ (2009) Control of cell membrane tension by myosin-I. Proc Natl Acad Sci USA 106:11972–11977PubMedGoogle Scholar
  156. Nelson CM, Jean RP, Tan JL, Liu WF, Sniadecki NJ, Spector AA, Chen CS (2005) Emergent patterns of growth controlled by multicellular form and mechanics. Proc Natl Acad Sci USA 102:11594–11599PubMedGoogle Scholar
  157. Neujahr R, Heizer C, Gerisch G (1997) Myosin II-independent processes in mitotic cells of Dictyostelium discoideum: redistribution of the nuclei, re-arrangement of the actin system and formation of the cleavage furrow. J Cell Sci 110:123–137PubMedGoogle Scholar
  158. Norden C, Young S, Link BA, Harris WA (2009) Actomyosin is the main driver of interkinetic nuclear migration in the retina. Cell 138:1195–1208PubMedCentralPubMedGoogle Scholar
  159. O'Connell CB, Wang YL (2000) Mammalian spindle orientation and position respond to changes in cell shape in a dynein-dependent fashion. Mol Biol Cell 11:1765–1774PubMedCentralPubMedGoogle Scholar
  160. Ou G, Stuurman N, D’Ambrosio M, Vale RD (2010) Polarized myosin produces unequal-size daughters during asymmetric cell division. Science 330:677–680PubMedCentralPubMedGoogle Scholar
  161. Palecek SP, Loftus JC, Ginsberg MH, Lauffenburger DA, Horwitz AF (1997) Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness. Nature 385:537–540PubMedGoogle Scholar
  162. Paluch E, Heisenberg C-P (2009) Biology and physics of cell shape changes in development. Curr Biol 19:R790–R799PubMedGoogle Scholar
  163. Pasternak C, Spudich J, Elson E (1989) Capping of surface receptors and concomitant cortical tension are generated by conventional myosin. Nature 341:549–551PubMedGoogle Scholar
  164. Perez-Mongiovi D, Chang P, Houliston E (1998) A propagated wave of MPF activation accompanies surface contraction waves at first mitosis in Xenopus. J Cell Sci 111:385–393PubMedGoogle Scholar
  165. Pfaendtner J, De La Cruz EM, Voth GA (2010) Actin filament remodeling by actin depolymerization factor/cofilin. Proc Natl Acad Sci USA 107:7299–7304PubMedGoogle Scholar
  166. Pollard TD (2010) Mechanics of cytokinesis in eukaryotes. Curr Opin Cell Biol 22:50–56PubMedCentralPubMedGoogle Scholar
  167. Pollard TD, Borisy GG (2003) Cellular motility driven by assembly and disassembly of actin filaments. Cell 112:453–465PubMedGoogle Scholar
  168. Pollard TD, Wu JQ (2010) Understanding cytokinesis: lessons from fission yeast. Nat Rev Mol Cell Biol 11:149–155PubMedCentralPubMedGoogle Scholar
  169. Popowicz GM, Schleicher M, Noegel AA, Holak TA (2006) Filamins: promiscuous organizers of the cytoskeleton. Trends Biochem Sci 31:411–419PubMedGoogle Scholar
  170. Pypaert M, Mundy D, Souter E, Labbé JC, Warren G (1991) Mitotic cytosol inhibits invagination of coated pits in broken mitotic cells. J Cell Biol 114:1159–1166PubMedGoogle Scholar
  171. Qin Y, Meisen WH, Hao Y, Macara IG (2010) Tuba, a Cdc42 GEF, is required for polarized spindle orientation during epithelial cyst formation. J Cell Biol 189:661–669PubMedGoogle Scholar
  172. Rafelski SM, Alberts JB, Odell GM (2009) An experimental and computational study of the effect of ActA polarity on the speed of Listeria monocytogenes actin-based motility. PLoS Comput Biol 5:e1000434PubMedCentralPubMedGoogle Scholar
  173. Rand RP, Burton AC (1964) Mechanical properties of the red cell membrane. I. Membrane stiffness and intracellular pressure. Biophys J 4:115–135PubMedCentralPubMedGoogle Scholar
  174. Rankin S, Kirschner MW (1997) The surface contraction waves of Xenopus eggs reflect the metachronous cell-cycle state of the cytoplasm. Curr Biol 7:451–454PubMedGoogle Scholar
  175. Rappaport R (1960) Cleavage of sand dollar eggs under constant tensile stress. J Exp Zool 144:225–231PubMedGoogle Scholar
  176. Rappaport R (1961) Experiments concerning the cleavage stimulus in sand dollar eggs. J Exp Zool 148:81–89PubMedGoogle Scholar
  177. Rappaport R (1996) Cytokinesis in animal cells. Cambridge University Press, Cambridge, UKGoogle Scholar
  178. Ratner S, Jasti RK, Heppner GH (1988) Motility of murine lymphocytes during transit through cell cycle. Analysis by a new in vitro assay. J Immunol 140:583–588PubMedGoogle Scholar
  179. Raucher D, Sheetz MP (1999) Membrane expansion increases endocytosis rate during mitosis. J Cell Biol 144:497–506PubMedGoogle Scholar
  180. Rauzi M, Verant P, Lecuit T, Lenne P-F (2008) Nature and anisotropy of cortical forces orienting Drosophila tissue morphogenesis. Nat Cell Biol 10:1401–1410PubMedGoogle Scholar
  181. Reichl EM, Effler JC, Robinson DN (2005) The stress and strain of cytokinesis. Trends Cell Biol 15:200–206PubMedGoogle Scholar
  182. Ren Y, Effler JC, Norstrom M, Luo T, Firtel RA, Iglesias PA, Rock RS, Robinson DN (2009) Mechanosensing through cooperative interactions between myosin II and the actin crosslinker cortexillin I. Curr Biol 19:1421–1428Google Scholar
  183. Riabowol K, Draetta G, Brizuela L, Vandre D, Beach D (1989) The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells. Cell 57:393–401PubMedGoogle Scholar
  184. Riveline D, Zamir E, Balaban NQ, Schwarz US, Ishizaki T, Narumiya S, Kam Z, Geiger B, Bershadsky AD (2001) Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism. J Cell Biol 153:1175–1186PubMedGoogle Scholar
  185. Robinson DN, Spudich JA (2004) Mechanics and regulation of cytokinesis. Curr Opin Cell Biol 16:182–188PubMedGoogle Scholar
  186. Roche S, Fumagalli S, Courtneidge SA (1995) Requirement for Src family protein tyrosine kinases in G2 for fibroblast cell division. Science 269:1567–1569PubMedGoogle Scholar
  187. Rodriguez-Fraticelli AE, Vergarajauregui S, Eastburn DJ, Datta A, Alonso MA, Mostov K, Martín-Belmonte F (2010) The Cdc42 GEF Intersectin 2 controls mitotic spindle orientation to form the lumen during epithelial morphogenesis. J Cell Biol 189:725–738PubMedGoogle Scholar
  188. Roux W (1894) Einleitung zum Archiv für Entwickelungsmechanik. Arch Embryol 1:1–42Google Scholar
  189. Rubinfeld B, Crosier WJ, Albert I, Conroy L, Clark R, McCormick F, Polakis P (1992) Localization of the rap1GAP catalytic domain and sites of phosphorylation by mutational analysis. Mol Cell Biol 12:4634–4642PubMedCentralPubMedGoogle Scholar
  190. Salbreux G (2008) Modélisation des instabilités du cortex d’actine. PhD thesis. Université Pierre et Marie Curie - Paris 6Google Scholar
  191. Salbreux G, Prost J, Joanny JF (2009) Hydrodynamics of cellular cortical flows and the formation of contractile rings. Phys Rev Lett 103:058102PubMedGoogle Scholar
  192. Sanger JW, Sanger JM (1980) Surface and shape changes during cell division. Cell Tissue Res 209:177–186PubMedGoogle Scholar
  193. Sausedo RA, Smith JL, Schoenwolf GC (1997) Role of nonrandomly oriented cell division in shaping and bending of the neural plate. J Comp Neurol 381:473–488PubMedGoogle Scholar
  194. Sawai T (1979) Cyclic changes in the cortical layer of non-nucleated fragments of the newt’s egg. J Embryol Exp Morphol 51:183–193PubMedGoogle Scholar
  195. Sawai T, Yoneda M (1974) Wave of stiffness propagating along the surface of the newt egg during cleavage. J Cell Biol 60:1–7PubMedGoogle Scholar
  196. Schenk J, Wilsch-Bräuninger M, Calegari F, Huttner WB (2009) Myosin II is required for interkinetic nuclear migration of neural progenitors. Proc Natl Acad Sci USA 106:16487–16492PubMedGoogle Scholar
  197. Schoenwolf GC, Alvarez IS (1989) Roles of neuroepithelial cell rearrangement and division in shaping of the avian neural plate. Development 106:427–439PubMedGoogle Scholar
  198. Schroeder TE (1990) The contractile ring and furrowing in dividing cells. Ann N Y Acad Sci 582:78–87PubMedGoogle Scholar
  199. Schuh M, Ellenberg J (2008) A new model for asymmetric spindle positioning in mouse oocytes. Curr Biol 18:1986–1992PubMedGoogle Scholar
  200. Schwarz EC, Neuhaus EM, Kistler C, Henkel AW, Soldati T (2000) Dictyostelium myosin IK is involved in the maintenance of cortical tension and affects motility and phagocytosis. J Cell Sci 113:621–633PubMedGoogle Scholar
  201. Schweitzer JK, Burke EE, Goodson HV, D'Souza-Schorey C (2005) Endocytosis resumes during late mitosis and is required for cytokinesis. J Biol Chem 280:41628–41635PubMedGoogle Scholar
  202. Seasholtz TM, Majumdar M, Kaplan DD, Brown JH (1999) Rho and Rho kinase mediate thrombin-stimulated vascular smooth muscle cell DNA synthesis and migration. Circ Res 84:1186–1193PubMedGoogle Scholar
  203. Sedzinski J, Biro M, Oswald A, Tinevez JY, Salbreux G, Paluch E (2011) Polar acto-myosin contractility destabilises the position of the cleavage furrow during cytokinesis. Nature (in press)Google Scholar
  204. Sells MA, Boyd JT, Chernoff J (1999) p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts. J Cell Biol 145:837–849PubMedGoogle Scholar
  205. Selman GG, Waddington CH (1955) The mechanism of cell division in the cleavage of the newt’s egg. J Exp Biol 32:700–733Google Scholar
  206. Sheetz MP (2001) Cell control by membrane-cytoskeleton adhesion. Nat Rev Mol Cell Biol 2:392–396PubMedGoogle Scholar
  207. Sheetz MP, Sable JE, Döbereiner H-G (2006) Continuous membrane-cytoskeleton adhesion requires continuous accommodation to lipid and cytoskeleton dynamics. Annu Rev Biophys Biomol Struct 35:417–434PubMedGoogle Scholar
  208. Shuster CB, Burgess DR (2002) Targeted new membrane addition in the cleavage furrow is a late, separate event in cytokinesis. Proc Natl Acad Sci USA 99:3633–3638PubMedGoogle Scholar
  209. Siegrist SE, Doe CQ (2006) Extrinsic cues orient the cell division axis in Drosophila embryonic neuroblasts. Development 133:529–536PubMedGoogle Scholar
  210. Skop AR, Bergmann D, Mohler WA, White JG (2001) Completion of cytokinesis in C. elegans requires a brefeldin A-sensitive membrane accumulation at the cleavage furrow apex. Curr Biol 11:735–746PubMedCentralPubMedGoogle Scholar
  211. Smith LG (2001) Plant cell division: building walls in the right places. Nat Rev Mol Cell Biol 2:33–39PubMedGoogle Scholar
  212. Solon J, Kaya A, Colombelli J, Brunner D (2009) Pulsed forces timed by a ratchet-like mechanism drive directed tissue movement during dorsal closure. Cell 137:1331–1342PubMedGoogle Scholar
  213. Staple DB, Farhadifar R, Röper JC, Aigouy B, Eaton S, Jülicher F (2010) Mechanics and remodelling of cell packings in epithelia. Eur Phys J E 33:117–127PubMedGoogle Scholar
  214. Steinman RM, Mellman IS, Muller WA, Cohn ZA (1983) Endocytosis and the recycling of plasma membrane. J Cell Biol 96:1–27PubMedGoogle Scholar
  215. Stephens L, Hardin J, Keller R, Wilt F (1986) The effects of aphidicolin on morphogenesis and differentiation in the sea urchin embryo. Dev Biol 118:64–69PubMedGoogle Scholar
  216. Stewart MP, Helenius J, Toyoda Y, Ramanathan SP, Muller DJ, Hyman AA (2011) Opposing activities of hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding. Nature 469:226–230Google Scholar
  217. Strangeways T (1922) Observations on the changes seen in living cells during growth and division. Proc R Soc B 94:137–141Google Scholar
  218. Strauss B, Adams RJ, Papalopulu N (2006) A default mechanism of spindle orientation based on cell shape is sufficient to generate cell fate diversity in polarised Xenopus blastomeres. Development 133:3883–3893PubMedGoogle Scholar
  219. Suzuki K, Takahashi K (2003) Reduced cell adhesion during mitosis by threonine phosphorylation of beta1 integrin. J Cell Physiol 197:297–305PubMedGoogle Scholar
  220. Szczepanowska J, Korn ED, Brzeska H (2006) Activation of myosin in HeLa cells causes redistribution of focal adhesions and F-actin from cell center to cell periphery. Cell Motil Cytoskeleton 63:356–374PubMedGoogle Scholar
  221. Thaw P, Baxter NJ, Hounslow AM, Price C, Waltho JP, Craven CJ (2001) Structure of TCTP reveals unexpected relationship with guanine nucleotide-free chaperones. Nat Struct Mol Biol 8:701–704Google Scholar
  222. Théry M, Bornens M (2006) Cell shape and cell division. Curr Opin Cell Biol 18:648–657PubMedGoogle Scholar
  223. Théry M, Bornens M (2008) Get round and stiff for mitosis. HSFP J 2:65–71Google Scholar
  224. Théry M, Racine V, Pépin A, Piel M, Chen Y, Sibarita J-B, Bornens M (2005) The extracellular matrix guides the orientation of the cell division axis. Nat Cell Biol 7:947–953PubMedGoogle Scholar
  225. Théry M, Jiménez-Dalmaroni A, Racine V, Bornens M, Jülicher F (2007) Experimental and theoretical study of mitotic spindle orientation. Nature 447:493–496PubMedGoogle Scholar
  226. Thompson DAW (1917) On growth and form. Cambridge University Press, Cambridge, UKGoogle Scholar
  227. Thoumine O, Cardoso O, Meister JJ (1999) Changes in the mechanical properties of fibroblasts during spreading: a micromanipulation study. Euro Biophys J 28:222–234Google Scholar
  228. Tinevez JY, Schulze U, Salbreux G, Roensch J, Joanny JF, Paluch E (2009) Role of cortical tension in bleb growth. Proc Natl Acad Sci USA 106:18581–18586PubMedGoogle Scholar
  229. Tsai MA, Waugh RE, Keng PC (1996) Cell cycle-dependence of HL-60 cell deformability. Biophys J 70:2023–2029PubMedCentralPubMedGoogle Scholar
  230. Tsai J-W, Lian W-N, Kemal S, Kriegstein AR, Vallee RB (2010) Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cells. Nat Neurosci 13:1463–1471Google Scholar
  231. Tsou M-FB, Ku W, Hayashi A, Rose LS (2003) PAR-dependent and geometry-dependent mechanisms of spindle positioning. J Cell Biol 160:845–855Google Scholar
  232. Tuomikoski T, Felix M-A, Dorée M, Gruenberg J (1989) Inhibition of endocytic vesicle fusion in vitro by the cell-cycle control protein kinase cdc2. Nature 342:942–945PubMedGoogle Scholar
  233. Tzur A, Kafri R, LeBleu VS, Lahav G, Kirschner MW (2009) Cell growth and size homeostasis in proliferating animal cells. Science 325:167–171PubMedCentralPubMedGoogle Scholar
  234. Vadlamudi RK, Li F, Adam L, Nguyen D, Ohta Y, Stossel TP, Kumar R (2002) Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1. Nat Cell Biol 4:681–690PubMedGoogle Scholar
  235. Van Eyk JE, Arrell DK, Foster DB, Strauss JD, Heinonen TYK, Furmaniak-Kazmierczak E, Côté GP, Mak AS (1998) Different molecular mechanisms for Rho family GTPase-dependent, Ca2+-independent contraction of smooth muscle. J Biol Chem 273:23433–23439PubMedGoogle Scholar
  236. Vogel SK, Raabe I, Dereli A, Maghelli N, Tolić-Nørrelykke IM (2007) Interphase microtubules determine the initial alignment of the mitotic spindle. Curr Biol 17:438–444PubMedGoogle Scholar
  237. Walmod PS, Hartmann-Petersen R, Prag S, Lepekhin EL, Röpke C, Berezin V, Bock E (2004) Cell-cycle-dependent regulation of cell motility and determination of the role of Rac1. Exp Cell Res 295:407-420Google Scholar
  238. Wang SW, Hertzler PL, Clark WH Jr (2008) Mesendoderm cells induce oriented cell division and invagination in the marine shrimp Sicyonia ingentis. Dev Biol 320:175–184PubMedGoogle Scholar
  239. Wang YL (2001) The mechanism of cytokinesis: reconsideration and reconciliation. Cell Struct Funct 26:633–638PubMedGoogle Scholar
  240. Wang YL, Taylor DL (1979) Distribution of fluorescently labeled actin in living sea urchin eggs during early development. J Cell Biol 81:672–679PubMedGoogle Scholar
  241. Warren G, Davoust J, Cockcroft A (1984) Recycling of transferrin receptors in A431 cells is inhibited during mitosis. EMBO J 3:2217–2225PubMedGoogle Scholar
  242. Warren SL, Nelson WJ (1987) Nonmitogenic morphoregulatory action of pp 60(v-src) on multicellular epithelial structures. Mol Cell Biol 7:1326–1337PubMedCentralPubMedGoogle Scholar
  243. Wei Y, Mikawa T (2000) Formation of the avian primitive streak from spatially restricted blastoderm: evidence for polarized cell division in the elongating streak. Development 127:87–96PubMedGoogle Scholar
  244. Werner M, Glotzer M (2008) Control of cortical contractility during cytokinesis. Biochem Soc Trans 36:371–377PubMedGoogle Scholar
  245. White JG, Borisy GG (1983) On the mechanisms of cytokinesis in animal cells. J Theor Biol 101:289–316PubMedGoogle Scholar
  246. Yamakita Y, Totsukawa G, Yamashiro S, Fry D, Zhang X, Hanks S, Matsumura F (1999) Dissociation of FAK/p130CAS/c-Src complex during mitosis: role of mitosis-specific serine phosphorylation of FAK. J Cell Biol 144:315–324PubMedGoogle Scholar
  247. Yamashiro S, Matsumura F (1991) Mitosis-specific phosphorylation of caldesmon: possible molecular mechanism of cell rounding during mitosis. BioEssays 13:563–568PubMedGoogle Scholar
  248. Yamashiro S, Yamakita Y, Ishikawa R, Matsumura F (1990) Mitosis-specific phosphorylation causes 83K non-muscle caldesmon to dissociate from microfilaments. Nature 344:675–678PubMedGoogle Scholar
  249. Yamashiro S, Chern H, Yamakita Y, Matsumura F (2001) Mutant Caldesmon lacking cdc2 phosphorylation sites delays M-phase entry and inhibits cytokinesis. Mol Biol Cell 12:239–250PubMedCentralPubMedGoogle Scholar
  250. Yang N, Higuchi O, Ohashi K, Nagata K, Wada A, Kangawa K, Nishida E, Mizuno K (1998) Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization. Nature 393:809–812PubMedGoogle Scholar
  251. Yeung A, Evans E (1989) Cortical shell-liquid core model for passive flow of liquid-like spherical cells into micropipets. Biophys J 56:139–149PubMedCentralPubMedGoogle Scholar
  252. Zeng Q, Lagunoff D, Masaracchia R, Goeckeler Z, Côté G, Wysolmerski R (2000) Endothelial cell retraction is induced by PAK2 monophosphorylation of myosin II. J Cell Sci 113:471–482PubMedGoogle Scholar
  253. Zhao Z, Rivkees SA (2003) Rho-associated kinases play an essential role in cardiac morphogenesis and cardiomyocyte proliferation. Dev Dyn 226:24–32PubMedGoogle Scholar
  254. Zumdieck A, Kruse K, Bringmann H, Hyman AA, Jülicher F (2007) Stress generation and filament turnover during actin ring constriction. PLoS One 2:e696PubMedCentralPubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Max Planck Institute of Molecular Cell Biology and GeneticsDresdenGermany
  2. 2.International Institute of Molecular and Cell BiologyWarsawPoland

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