Mechanisms of Transcriptional Activation in Eukaryotes
Eukaryotic cells respond to growth, developmental and environmental cues in large part by regulating the expression of specific sets of genes. Befitting the wide range of these signals and the proper gene regulatory response, mechanisms of transcriptional activation in eukaryotes are impressively diverse. These mechanisms are built on the modular design of cis-acting DNA regulatory sequences and of trans-acting regulatory proteins, coupled with flexibility and diversity in the protein:protein interactions linking activators to chromatin-modifying enzymes and general transcription factors. This review summarizes and illustrates these principles of modular design and combinatorial logic underlying transcriptional activation in eukaryotes.
KeywordsGene regulation Transcription RNA polymerase II Chromatin Enhancer
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