Chapter

TOR

Volume 279 of the series Current Topics in Microbiology and Immunology pp 73-84

Autophagy in Yeast: ATOR-Mediated Response to Nutrient Starvation

  • Y. KamadaAffiliated withDepartment of Cell Biology, National Institute for Basic Biology
  • , T. SekitoAffiliated withDepartment of Cell Biology, National Institute for Basic Biology
  • , Y. OhsumiAffiliated withDepartment of Cell Biology, National Institute for Basic Biology

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Abstract

TOR plays a key role in cell growth and cell-cycle progression, but in addition recent studies have shown that TOR is also involved in the regulation of a number of molecular processes associated with nutrient deprivation, such as autophagy. In budding yeast, TOR negatively regulates activation of Apg1 protein kinase, which is essential for the induction of autophagy. This review describes recent research in this field and the mechanism by which TOR mediates induction of autophagy.