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TOR pp 19-38 | Cite as

The Role of Phosphatases in TOR Signaling in Yeast

  • K. Düvel
  • J. R. Broach
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 279)

Abstract

The TOR pathway controls cellular functions necessary for cell growth and proliferation of yeast and larger eukaryotes. The search for members of the TOR signaling cascade in yeast led to the discovery of type 2A protein phosphatases (PP2A) as important players within the pathway. We describe the roles in yeast of PP2A and the closely related phosphatase, Sit4, and then focus on complexes formed between the catalytic subunit of these phosphatases and Tap42, a direct target of the Tor protein kinases in yeast. Recent results suggest that Tap42 mediates many of the Tor functions in yeast, especially those involved in transcriptional modulation. However, whether Tap42 executes its function by inhibiting phosphatase activity or by activating phosphatases is still uncertain. In addition, Tor affects some transcriptional and physiological processes through Tap42 independent pathways. Thus, Tor proteins use multiple mechanisms to regulate transcriptional and physiological processes in yeast.

Keywords

Rapamycin Treatment Spindle Checkpoint PP2A Activity Anaphase Promote Complex Amino Acid Permease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • K. Düvel
    • 1
  • J. R. Broach
    • 1
  1. 1.Department of Molecular BiologyPrinceton UniversityPrincetonUSA

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