Modelling Stochastic Clonal Interference

  • Paulo RA Campos
  • Christoph Adami
  • Claus O. Wilke
Part of the Natural Computing Series book series (NCS)

Summary

We study the competition between several advantageous mutants in an asexual population (clonal interference) as a function of the time between the appearance of the mutants ∆t, their selective advantages, and the rate of deleterious mutations. We find that the overall probability of fixation (the probability that at least one of the mutants becomes the ancestor of the entire population) does not depend on the time interval between the appearance of these mutants, and equals the probability that a genotype bearing all of these mutations reaches fixation. This result holds also in the presence of deleterious mutations, and for an arbitrary number of competing mutants. We also show that if mutations interfere, an increase in the mean number of fixation events is associated with a decrease in the expected fitness gain of the population.

Keywords

Mutation Rate Selective Advantage Deleterious Mutation Error Threshold Wild Type Sequence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • Paulo RA Campos
    • 1
  • Christoph Adami
    • 2
  • Claus O. Wilke
    • 1
  1. 1.Digital Life Laboratory 136-93California Institute of TechnologyPasadena
  2. 2.Jet Propulsion Laboratory 126-347California Institute of TechnologyUSA

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