Separation Techniques in Effect-Directed Analysis

  • Werner BrackEmail author
  • Nadin Ulrich
  • Mahmoud Bataineh
Part of the The Handbook of Environmental Chemistry book series (HEC, volume 15)


The continuous development of new chemicals enhances the complexity of environmental analysis and poses a risk to environmental and human health. Awareness is increasing that together with the chemical products on the market, the enormous number of transformation and by-products may contribute to this risk. Effect-directed analysis (EDA) has been developed to identify major toxicants in such complex mixtures. Separation techniques in EDA are applied to reduce the complexity of environmental mixtures and provide valuable information on physicochemical and thus structural properties of candidate toxicants. Within the last decades, separation science provided an extensive understanding of processes and mechanisms in chromatography, developed novel stationary phases with specific separation properties, and introduced modeling tools such as linear solvation energy relationships (LSER) to predict retention. A selection of these tools is compiled in the present paper to support the exploitation of present knowledge on chromatography to enhance the ability to identify so far unknown toxicants in complex mixtures.


Fractionation LSER Mechanism QSRR Retention prediction Stationary phase 


  1. 1.
    Ho KT, Mills LJ, Mueller C, Anderson SC, Malcolm AR (1994) Environ Toxicol Water Qual 9:145–154Google Scholar
  2. 2.
    Kaliszan R (1997) Structure and retention in chromatography. A chemometric approach. Harwood, AmsterdamGoogle Scholar
  3. 3.
    Schwarzenbach RP, Gschwend PM, Imboden DM (2003) Environmental organic chemistry. Wiley, Hoboken, NJGoogle Scholar
  4. 4.
    Vitha M, Carr PW (2006) J Chromatogr A 1126:143–194Google Scholar
  5. 5.
    Klinkow N, Oleksy-Frenzel J, Jekel M (1998) Water Res 32:2583–2593Google Scholar
  6. 6.
    Kubátova A, Dronen LC, Hawthorne SB (2006) Environ Toxicol Chem 25:1742–1745Google Scholar
  7. 7.
    Kubatova A, Jansen B, Vaudoisot JF, Hawthorne SB (2002) J Chromatogr A 975:175–188Google Scholar
  8. 8.
    Kubátova A, Steckler TS, Gallagher JR, Hawthorne SB, Picklo MJ (2004) Environ Toxicol Chem 23:2243–2250Google Scholar
  9. 9.
    Brack W, Frank H (1997) Chemosphere 34:849–854Google Scholar
  10. 10.
    Brack W, Rottler H, Frank H (1998) Environ Toxicol Chem 17:1982–1991Google Scholar
  11. 11.
    Ho KTY, Quinn JG (1993) Environ Toxicol Chem 12:615–625Google Scholar
  12. 12.
    Holmborn B, Voss RH, Mortimer RD, Wong A (1984) Environ Sci Technol 18:333–337Google Scholar
  13. 13.
    Cancilla DA, Holtkamp A, Matassa L, Fang XC (1997) Environ Toxicol Chem 16:430–434Google Scholar
  14. 14.
    Sauer TC, Costa HJ, Brown JS, Ward TJ (1997) Environ Toxicol Chem 16:2020–2028Google Scholar
  15. 15.
    Dobias L, Kusova J, Gajdos O et al (1999) Mutat Res 445:285–293Google Scholar
  16. 16.
    Samoiloff MR, Bell J, Birkholz DA et al (1983) Environ Sci Technol 17:329–334Google Scholar
  17. 17.
    Lewtas J, Chuang J, Nishioka M, Petersen B (1990) Int J Environ Anal Chem 39:245–256Google Scholar
  18. 18.
    DeMarini DM, Shelton ML, Bell DA (1996) Mutat Res 349:1–20Google Scholar
  19. 19.
    Meyer S, Cartellieri S, Steinhart H (1999) Anal Chem 71:4023–4029Google Scholar
  20. 20.
    Baczek T, Kaliszan R, Novotná K, Jandera P (2005) J Chromatogr A 1075:109–115Google Scholar
  21. 21.
    Baczek T, Kaliszan R (2003) J Chromatogr A 987:29–37Google Scholar
  22. 22.
    Abraham MH, Ibrahim A, Zissimos AM (2004) J Chromatogr A 1037:29–47Google Scholar
  23. 23.
    Abraham MH, McGowan JC (1987) Chromatographia 23:243–246Google Scholar
  24. 24.
    Heberger K (2007) J Chromatogr A 1158:273–305Google Scholar
  25. 25.
    Tulp HC, Goss KU, Schwarzenbach RP, Fenner K (2008) Environ Sci Technol 42:2034–2040Google Scholar
  26. 26.
    Abraham MH, Chadha HS, Whiting GS, Mitchell RC (1994) J Pharm Sci 83:1085–1100Google Scholar
  27. 27.
    Abraham MH, Andonianhaftvan J, Whiting GS, Leo A, Taft RS (1994) J Chem Soc Perkin Trans 2:1777–1791Google Scholar
  28. 28.
    Abraham MH, Al-Hussaini AJM (2001) J Environ Monit 3:377–381Google Scholar
  29. 29.
    Abraham MH, Al-Hussaini AJM (2005) J Environ Monit 7:295–301Google Scholar
  30. 30.
    Abraham MH, Al-Hussaini AJM (2002) J Environ Monit 4:743–746Google Scholar
  31. 31.
    Turowski M, Morimoto T, Kimata K et al (2001) J Chromatogr A 911:177–190Google Scholar
  32. 32.
    Zissimos AM, Abraham MH, Du CM et al (2002) J Chem Soc Perkin Trans 2:2001–2010Google Scholar
  33. 33.
    Abraham MH, Roses M, Poole CF, Poole SK (1997) J Phy Org Chem 10:358–368Google Scholar
  34. 34.
    Snyder LR, Dolan JW, Carr PW (2004) J Chromatogr A 1060:77–116Google Scholar
  35. 35.
    Platts JA, Abraham MH, Butina D, Hersey A (2000) J Chem Inf Comp Sci 40:71–80Google Scholar
  36. 36.
    Valko K, Bevan C, Reynolds D (1997) Anal Chem 69:2022–2029Google Scholar
  37. 37.
    Valko K (2004) J Chromatogr A 1037:299–310Google Scholar
  38. 38.
    Valko K, Du CM, Bevan C, Reynolds DP, Abraham MH (2001) Curr Med Chem 8:1137–1146Google Scholar
  39. 39.
    Jalali-Heravi M, Garkani-Nejad Z, Kyani A (2008) QSAR Comb Sci 27:137–146Google Scholar
  40. 40.
    Wise SA, Bonnett WJ, Guenther FR, May WE (1981) J Chromatogr Sci 19:457–465Google Scholar
  41. 41.
    Garrigues P, Bellocq J, Wise SA (1990) Fresen J Anal Chem 336:106–110Google Scholar
  42. 42.
    Bataineh M, Lübcke-von Varel U, Hayen H, Brack W (2010) J Am Soc Mass Spectrom. doi:10.1016/j.jasms.2010.02.015Google Scholar
  43. 43.
    Jop KM, Kendall TZ, Askew AM, Foster RB (1991) Environ Toxicol Chem 10:981–990Google Scholar
  44. 44.
    Desbrow C, Routledge EJ, Brighty GC, Sumpter JP, Waldock M (1998) Environ Sci Technol 32:1549–1558Google Scholar
  45. 45.
    Euerby MR, Petersson P (2005) J Chromatogr A 1088:1–15Google Scholar
  46. 46.
    Euerby MR, Petersson P (2003) J Chromatogr A 994:13–36Google Scholar
  47. 47.
    Petersson P, Euerby MR (2005) J Sep Sci 28:2120–2129Google Scholar
  48. 48.
    Euerby MR, Petersson P, Campbell W, Roe W (2007) J Chromatogr A 1154:138–151Google Scholar
  49. 49.
    Neue UD, VanTran K, Iraneta PC, Alden BA (2003) J Sep Sci 26:174–186Google Scholar
  50. 50.
    Jinno K, Okumura C, Taniguchi M, Chen YL (1997) Chromatographia 44:613–618Google Scholar
  51. 51.
    Tanaka N, Tokuda Y, Iwaguchi K, Araki M (1982) J Chromatogr 239:761–772Google Scholar
  52. 52.
    Brindle R, Albert K (1997) J Chromatogr A 757:3–20Google Scholar
  53. 53.
    Grosse-Rhode C, Kicinski HG, Kettrup A (1990) Chromatographia 29:489–494Google Scholar
  54. 54.
    Horak J, Lindner W (2004) J Chromatogr A 1043:177–194Google Scholar
  55. 55.
    Monde T, Kamiusuki T, Kuroda T, Mikumo K, Ohkawa T, Fukube H (1996) J Chromatogr A 722:273–280Google Scholar
  56. 56.
    Benskin JP, Bataineh M, Martin JW (2007) Anal Chem 79:6455–6464Google Scholar
  57. 57.
    Kimata K, Hosoya K, Araki T et al (1993) Anal Chem 65:2502–2509Google Scholar
  58. 58.
    Kimata K, Hosoya K, Kuroki H et al (1997) J Chromatogr A 786:237–248Google Scholar
  59. 59.
    Ascah TL, Feibush B (1990) J Chromatogr A 506:357–369Google Scholar
  60. 60.
    Layne J (2002) J Chromatogr A 957:149–164Google Scholar
  61. 61.
    Venkatramani CJ, Zelechonok Y (2005) J Chromatogr A 1066:47–53Google Scholar
  62. 62.
    Sandi A, Nagy M, Szepesy L (2000) J Chromatogr A 893:215–234Google Scholar
  63. 63.
    Valko K, Espinosa S, Du CM et al (2001) J Chromatogr A 933:73–81Google Scholar
  64. 64.
    Wilson NS, Nelson MD, Dolan JW, Snyder LR, Wolcott RG, Carr PW (2002) J Chromatogr A 961:171–193Google Scholar
  65. 65.
    Wilson NS, Dolan JW, Snyder LR, Carr PW, Sander LC (2002) J Chromatogr A 961:217–236Google Scholar
  66. 66.
    Wilson NS, Nelson MD, Dolan JW, Snyder LR, Carr PW (2002) J Chromatogr A 961:195–215Google Scholar
  67. 67.
    Copper CL, Sepaniak MJ (1994) Anal Chem 66:147–154Google Scholar
  68. 68.
    Arnold EN, Lillie TS, Beesley TE (1989) J Liq Chromatogr 12:337–343Google Scholar
  69. 69.
    Alpert AJ (1990) J Chromatogr 499:177–196Google Scholar
  70. 70.
    Wernersson AS, Dave G (1997) Arch Environ Contam Toxicol 32:268–273Google Scholar
  71. 71.
    Kosian PA, Makynen EA, Monson PD et al (1998) Environ Toxicol Chem 17:1021–1033Google Scholar
  72. 72.
    Ho KT, McKinney RA, Kuhn A, Pelletier MC, Burgess RM (1997) Environ Toxicol Chem 16:551–558Google Scholar
  73. 73.
    Elias-Samlalsingh N, Agard JBR (2004) Environ Toxicol Chem 23:1194–1203Google Scholar
  74. 74.
    Jin HJ, Yang X, Yin DQ, Yu HX (1999) Mar Pollut Bull 39:122–125Google Scholar
  75. 75.
    Fort DJ, Rogers RL, Copley HF et al (1999) Environ Toxicol Chem 18:2316–2324Google Scholar
  76. 76.
    Burgess RM, Ho KT, Tagliabue MD et al (1995) Mar Pollut Bull 30:524–535Google Scholar
  77. 77.
    Burkhard LP, Durhan EJ, Lukasewycz MT (1991) Anal Chem 63:277–283Google Scholar
  78. 78.
    Bailey HC, Elphick JR, Krassol R, Mulhall A-M, Lovell AJ, Slee DJ (2005) Environ Toxicol Chem 24:1773–1778Google Scholar
  79. 79.
    Bailey HC, Elphick JR, Krassoi R, Lovell A (2001) Environ Toxicol Chem 20:2877–2882Google Scholar
  80. 80.
    Ankley GT, Mekenyan OG, Kosian PA et al (1996) SAR QSAR Environ Res 5:177–183Google Scholar
  81. 81.
    Amato JR, Mount DI, Durhan EJ, Lukasewycz MT, Ankley GT, Robert ED (1992) Environ Toxicol Chem 11:209–216Google Scholar
  82. 82.
    Mount DI, Anderson-Carnahan L (1989) Methods for aquatic toxicity identification evaluations. Phase II toxicity identification procedures (EPA/600/3-88/035). United States Environmental Protection Agency, Washington, DCGoogle Scholar
  83. 83.
    Lukasewycz M, Durhan E (1992) J Chromatogr 580:215–228Google Scholar
  84. 84.
    Hewitt LM, Marvin CH (2005) Mutat Res Rev Mutat Res 589:208–232Google Scholar
  85. 85.
    Thomas KV, Thain JE, Waldock MJ (1999) Environ Toxicol Chem 18:401–411Google Scholar
  86. 86.
    Thomas KV, Hurst MR, Matthiessen P, Waldock MJ (2001) Environ Toxicol Chem 20:2165–2170Google Scholar
  87. 87.
    Farre M, Kloter G, Petrovic M, Alonso MC, de Alda MJL, Barcelo D (2002) Analyt Chim Acta 456:19–30Google Scholar
  88. 88.
    Castillo M, Alonso MC, Riu J, Barceló D (1999) Environ Sci Technol 33:1300–1306Google Scholar
  89. 89.
    Scheurell M, Franke S, Huhnerfuss H (2007) Int J Environ Anal Chem 87:401–413Google Scholar
  90. 90.
    Hewitt LM, Smyth SAM, Dube MG, Gilman CI, MacLatchy DL (2002) Environ Toxicol Chem 21:1359–1367Google Scholar
  91. 91.
    Fiehn O, Jekel M (1996) Anal Chem 68:3083–3089Google Scholar
  92. 92.
    Fiehn O, Vigelahn L, Kalnowski G, Reemtsma T, Jekel M (1997) Acta Hydrochim Hydrobiol 25:11–16Google Scholar
  93. 93.
    Reemtsma T, Putschew A, Jekel M (1999) Waste Manag 19:181–188Google Scholar
  94. 94.
    Castillo M, Barceló D (2001) Analyt Chim Acta 426:253–264Google Scholar
  95. 95.
    Castillo M, Alonso MC, Riu J et al (2001) Analyt Chim Acta 426:265–277Google Scholar
  96. 96.
    Castillo M, Barceló D (1999) Anal Chem 71:3769–3776Google Scholar
  97. 97.
    Thomas KV, Hurst MR, Matthiessen P, Sheahan D, Williams RJ (2001) Water Res 35:2411–2416Google Scholar
  98. 98.
    Sayato Y, Nakamuro K, Ueno H, Goto R (1993) Mutat Res 300:207–213Google Scholar
  99. 99.
    Thomas KV, Hurst MR, Matthiessen P, McHugh M, Smith A, Waldock MJ (2002) Environ Toxicol Chem 21:1456–1461Google Scholar
  100. 100.
    Rastall AC, Getting D, Goddard J, Roberts DR, Erdinger L (2006) Environ Sci Pollut Res 13:256–267Google Scholar
  101. 101.
    Reemtsma T, Fiehn O, Jekel M (1999) Fresen J Anal Chem 363:771–776Google Scholar
  102. 102.
    Svenson A, Norin H, Hynning PA (1996) Environ Toxicol Wat Qual 11:277–284Google Scholar
  103. 103.
    Svenson A, Sanden B, Dalhammar G, Remberger M, Kaj L (2000) Environ Toxicol 15:527–532Google Scholar
  104. 104.
    Reineke N, Bester K, Hühnerfuss H, Jastorff B, Weigel S (2002) Chemosphere 47:717–723Google Scholar
  105. 105.
    Burnison BK, Hodson PV, Nuttley DJ, Efler S (1996) Environ Toxicol Chem 15:1524–1531Google Scholar
  106. 106.
    Burnison BK, Hartmann A, Lister A, Servos MR, Ternes T, van der Kraak G (2003) Environ Toxicol Chem 22:2243–2250Google Scholar
  107. 107.
    Weiss JM, Hamers T, Thomas KV, van der Linden SC, Leonards P, Lamoree M (2009) Anal Bioanal Chem 394:1385–1397Google Scholar
  108. 108.
    Suzuki G, Takigami H, Kushi Y, Sakai S (2006) Toxicol Lett 161:174–187Google Scholar
  109. 109.
    Houtman CJ, Van Oostveen AM, Brouwer A, Lamoree MH, Legler J (2004) Environ Sci Technol 38:6415–6423Google Scholar
  110. 110.
    Hewitt LM, Parrott JL, Wells KL et al (2000) Environ Sci Technol 34:4327–4334Google Scholar
  111. 111.
    Hewitt M, Schryer R, Pryce A, Belknap A, Firth B, van der Kraak G (2005) Water Qual Res J Canada 40:315–327Google Scholar
  112. 112.
    Hewitt LM, Pryce AC, Parrott JL et al (2003) Environ Toxicol Chem 22:2890–2897Google Scholar
  113. 113.
    Hewitt LM, Tremblay L, Van der Kraak GJ, Solomon KR, Servos MR (1998) Environ Toxicol Chem 17:425–432Google Scholar
  114. 114.
    Hewitt LM, Munkittrick KR, Scott IM, Carey JH, Solomon KR, Servos MR (1996) Environ Toxicol Chem 15:894–905Google Scholar
  115. 115.
    Brack W, Altenburger R, Küster E, Meissner B, Wenzel K-D, Schüürmann G (2003) Environ Toxicol Chem 22:2228–2237Google Scholar
  116. 116.
    Schulze T, Weiss S, Schymanski E et al (2010) Environ Pollut 158:1461–1466Google Scholar
  117. 117.
    Matsushita T, Matsui Y, Matsui Yu (2006) Chemosphere 64:144–151Google Scholar
  118. 118.
    Lewtas J, King LC, Williams K, Ball LM, DeMarini DM (1990) Mutagenesis 5:481–489Google Scholar
  119. 119.
    Galassi S, Benfenati E (2000) J Chromatogr A 889:149–154Google Scholar
  120. 120.
    Grung M, Lichtenthaler R, Ahel M, Tollefsen KE, Langford K, Thomas KV (2007) Chemosphere 67:108–120Google Scholar
  121. 121.
    Watanabe T, Ohba H, Asanoma M et al (2006) Mutat Res Genet Toxicol Environ Mutagen 609:137–145Google Scholar
  122. 122.
    Watanabe T, Hasai T, Ohe T, Hirayama T, Wakabayashi K (2006) Detection of 3,3′-Dichlorobenzidine in water from the Waka river in Wakayama, Japan. Genes Environ Off J Jpn Environ Mutag Soc 28(4):173–180Google Scholar
  123. 123.
    Beck IC, Bruhn R, Gandrass J (2006) Acta Hydrochim Hydrobiol 34:560–567Google Scholar
  124. 124.
    Ballschmiter K, Wossner M (1998) Fresen J Anal Chem 361:743–755Google Scholar
  125. 125.
    Carlsson H, Ístman C (1995) J Chromatogr A 715:31–39Google Scholar
  126. 126.
    Li J, Whitman DA (1998) Analyt Chim Acta 368:141–154Google Scholar
  127. 127.
    Waksmundzka-Hajnos M, Petruczynik A, Hawryl A (2001) J Chromatogr A 919:39–50Google Scholar
  128. 128.
    Ulrich N (2009) Bestimmung der Phasenparameter ausgewählter HPLC-Systeme, Master ThesisGoogle Scholar
  129. 129.
    Salotto AW, Weiser EL, Caffey KP, Carty RL, Racine SC, Snyder LR (1990) J Chromatogr A 498:55–65Google Scholar
  130. 130.
    Snyder SA, Villeneuve DL, Snyder EM, Giesy JP (2001) Environ Sci Technol 35:3620–3625Google Scholar
  131. 131.
    Snyder SA, Keith TL, Verbrugge DA et al (1999) Environ Sci Technol 33:2814–2820Google Scholar
  132. 132.
    Marvin CH, Tessaro M, McCarry BE, Bryant DW (1994) Sci Tot Environ 156:119–131Google Scholar
  133. 133.
    Brack W, Altenburger R, Ensenbach U, Möder M, Segner H, Schüürmann G (1999) Arch Environ Contam Toxicol 37:164–174Google Scholar
  134. 134.
    Brack W, Schirmer K, Kind T, Schrader S, Schüürmann G (2002) Environ Toxicol Chem 21:2654–2662Google Scholar
  135. 135.
    Brack W, Schirmer K (2003) Environ Sci Technol 37:3062–3070Google Scholar
  136. 136.
    Brack W, Schirmer K, Erdinger L, Hollert H (2005) Environ Toxicol Chem 24:2445–2458Google Scholar
  137. 137.
    Brack W, Blaha L, Giesy JP et al (2008) Environ Toxicol Chem 27:519–528Google Scholar
  138. 138.
    Brooks LR, Hughes TJ, Claxton LD, Austern B, Brenner R, Kremer F (1998) Environ Health Perspect 106 Supplement 6:1435–1440Google Scholar
  139. 139.
    Arey J, Harger WP, Helmig D, Atkinson R (1992) Mutat Res 281:67–76Google Scholar
  140. 140.
    DeMarini DM, Williams RW, Brooks LR, Taylor MS (1992) Int J Environ Anal Chem 48:187–199Google Scholar
  141. 141.
    Sundberg H, Ishaq R, Akerman G et al (2005) Tox Sci 84:63–72Google Scholar
  142. 142.
    Brunström B, Broman D, Dencker L, Näf C, Vejlens E, Zebühr Y (1992) Environ Toxicol Chem 11:1441–1449Google Scholar
  143. 143.
    Zebühr Y, Näf C, Bandh C, Broman D, Ishaq R, Pettersen H (1993) Chemosphere 27:1211–1219Google Scholar
  144. 144.
    Engwall M, Broman D, Dencker L, Näf C, Zebühr Y, Brunström B (1997) Environ Toxicol Chem 16:1187–1194Google Scholar
  145. 145.
    Wiklund A-KE, Broman BSD (2005) Mar Pollut Bull 50:660–667Google Scholar
  146. 146.
    DeMarini DM, Williams RW, Perry E, Lemieux PM, Linak WP (1992) Combust Sci Technol 85:437–453Google Scholar
  147. 147.
    Pedersen DU, Durant JL, Penman BW et al (2004) Environ Sci Technol 38:682–689Google Scholar
  148. 148.
    Pedersen DU, Durant JL, Taghizadeh K, Hemond HF, Lafleur AL, Cass GR (2005) Environ Sci Technol 39:9547–9560Google Scholar
  149. 149.
    Kammann U, Biselli S, Hühnerfuss H et al (2004) Environ Pollut 132:279–287Google Scholar
  150. 150.
    Biselli S, Reineke N, Heinzel N et al (2005) J Soils Sediments 5:171–181Google Scholar
  151. 151.
    Durant JL, Thilly WG, Hemond HF, Lafleur AL (1994) Environ Sci Technol 28:2033–2044Google Scholar
  152. 152.
    Durant JL, Lafleur AL, Plummer EF, Taghizadeh K, Busby WF, Thilly WG (1998) Environ Sci Technol 32:1894–1906Google Scholar
  153. 153.
    Brack W, Kind T, Hollert H, Schrader S, Möder M (2003) J Chromatogr A 986:55–66Google Scholar
  154. 154.
    Lübcke-von Varel U, Streck G, Brack W (2008) J Chromatogr A 1185:31–42Google Scholar
  155. 155.
    Bandow N, Altenburger R, Streck G, Brack W (2009) Environ Sci Technol 43:7343–7349Google Scholar
  156. 156.
    Schwab K, Altenburger R, Lübcke-von Varel U, Streck G, Brack W (2009) Environ Toxicol Chem 28:1506–1517Google Scholar
  157. 157.
    Kaisarevic S, Lübcke-von Varel U, Orcic D et al (2009) Chemosphere 77:907–913Google Scholar
  158. 158.
    Gundel LA, Mahanama RR, Daisey JM (1993) J Chromatogr A 629:75–82Google Scholar
  159. 159.
    Thomas KV, Balaam J, Barnard N et al (2002) Chemosphere 49:247–258Google Scholar
  160. 160.
    Thomas KV, Balaam J, Hurst MR, Thain JE (2004) Environ Toxicol Chem 23:1156–1163Google Scholar
  161. 161.
    Thomas KV, Langford K, Petersen K, Smith AJ, Tollefsen KE (2009) Environ Sci Technol 43:8066–8071Google Scholar
  162. 162.
    Marvin CH, Lundrigan JA, McCarry BE, Bryant DW (1995) Environ Toxicol Chem 14:2059–2066Google Scholar
  163. 163.
    Marvin CH, McCarry BE, Villella J, Allan LM, Bryant DW (2000) Chemosphere 41:989–999Google Scholar
  164. 164.
    Kaminski M, Kartanowicz R, Gilgenast E, Namiesnik J (2005) Crit Rev Anal Chem 35:193–216Google Scholar
  165. 165.
    Borgund AE, Erstad K, Barth T (2007) J Chromatogr A 1149:189–196Google Scholar
  166. 166.
    Islas-Flores CA, Buenrostro-Gonzalez E, Lira-Galeana C (2006) Fuel 85:1842–1850Google Scholar
  167. 167.
    Grote M, Brack W, Walter HA, Altenburger R (2005) Environ Toxicol Chem 24:1420–1427Google Scholar
  168. 168.
    Grote M, Altenburger R, Brack W et al (2005) Acta Hydrochim Hydrobiol 3:555–569Google Scholar
  169. 169.
    Grote M, Brack W, Altenburger R (2005) Environ Toxicol 20:475–486Google Scholar
  170. 170.
    Bandh C, Ishaq R, Broman D, Näf C, Rönquist-Nii Y, Zebühr Y (1996) Environ Sci Technol 30:214–219Google Scholar
  171. 171.
    Brack W, Kind T, Schrader S, Möder M, Schüürmann G (2003) Environ Pollut 121:81–85Google Scholar
  172. 172.
    Haglund P, Jacobsson E, Masuda Y (1995) Organohal Comp 26:405–410Google Scholar
  173. 173.
    Ramos L, Hernandez LM, Gonzales MJ (1999) Anal Chem 71:70–77Google Scholar
  174. 174.
    Jaouen-Madoulet A, Abarnou A, Le Guellec A-M, Loizeau V, Leboulenger F (2000) J Chromatogr A 886:153–173Google Scholar
  175. 175.
    Craeser CS, Al Haddad A (1989) Anal Chem 61:1300–1302Google Scholar
  176. 176.
    Chu S, Hong CS, Rattner BA, McGowan PC (2003) Anal Chem 75:1058–1066Google Scholar
  177. 177.
    Stalling DL, Guo CY, Saim S (1993) J Chromatogr Sci 31:265–278Google Scholar
  178. 178.
    Feltz KP, Tillitt D, Gale RW, Peterman PH (1995) Environ Sci Technol 29:709–718Google Scholar
  179. 179.
    Gundersen H (2001) J Chromatogr A 914:161–166Google Scholar
  180. 180.
    Hemstrom P, Irgum K (2006) J Sep Sci 29:1784–1821Google Scholar
  181. 181.
    Diener M, Erler K, Christian B, Luckas B (2007) J Sep Sci 30:1821–1826Google Scholar
  182. 182.
    Oertel R, Neumeister V, Kirch W (2004) J Chromatogr A 1058:197–201Google Scholar
  183. 183.
    Bengtsson J, Jansson B, Hammarlund-Udenaes M (2005) Rapid Commun Mass Spectrom 19:2116–2122Google Scholar
  184. 184.
    Ikegami T, Tomomatsu K, Takubo H, Horie K, Tanaka N (2008) J Chromatogr A 1184:474–503Google Scholar
  185. 185.
    Barth HG, Boyes BE, Jackson C (1998) Anal Chem 70:251R–278RGoogle Scholar
  186. 186.
    Fernandez P, Grifoll M, Solanas AM, Bayona JM, Albaiges J (1992) Environ Sci Technol 26:817–829Google Scholar
  187. 187.
    Hannigan MP, Cass GR, Penman BW et al (1998) Environ Sci Technol 32:3502–3514Google Scholar
  188. 188.
    White PA, Rasmussen JB, Blaise C (1998) Environ Toxicol Chem 17:304–316Google Scholar
  189. 189.
    Houtman CJ, Leonards PEG, Kapiteijn W et al (2007) Sci Total Environ 386:134–144Google Scholar
  190. 190.
    Parrott JL, van den Heuvel MR, Hewitt LM, Baker MA, Munkittrick KR (2000) Chemosphere 41:1083–1089Google Scholar
  191. 191.
    Harris GE, Metcalfe TL, Metcalfe CD, Huestis SY (1994) Environ Toxicol Chem 13:1393–1403Google Scholar
  192. 192.
    Gagne F, Pardos M, Blaise C, Turcotte P, Quemerais B, Fouquet A (1999) Chemosphere 39:1545–1570Google Scholar
  193. 193.
    Gale RW, Long ER, Schwartz TR, Tillitt DE (2000) Environ Toxicol Chem 19:1348–1359Google Scholar
  194. 194.
    Fernandez P, Bayona JM (1992) J Chromatogr 625:141–149Google Scholar
  195. 195.
    Donkin P, Smith EL, Rowland SJ (2003) Environ Sci Technol 37:4825–4830Google Scholar
  196. 196.
    Donkin P, Evans SV (1984) Analyt Chim Acta 156:207–219Google Scholar
  197. 197.
    Streck HG, Schulze T, Brack W (2008) J Chromatogr A 1196–1197:33–40Google Scholar
  198. 198.
    Seiler TB, Rastall AC, Leist E, Erdinger L, Braunbeck T, Hollert H (2006) J Soils Sediments 6:20–29Google Scholar
  199. 199.
    Bergqvist PA, Strandberg B, Rappe C (1999) Chemosphere 38:933–943Google Scholar
  200. 200.
    Strandberg B, Bergqvist PA, Rappe C (1998) Anal Chem 70:526–533Google Scholar
  201. 201.
    Higashi RM, Cherr GN, Shenker JM, Macdonald JM, Crosby DG (1992) Environ Sci Technol 26:2413–2420Google Scholar
  202. 202.
    Haglund P, Jacobsson E, Asplund L, Athanasiadou M, Bergman A (1993) J Chromatogr 634:79–86Google Scholar
  203. 203.
    Heisterkamp I, Gandrass J, Ruck W (2004) Anal Bioanal Chem 378:709–715Google Scholar
  204. 204.
    Bilitewski U, Brenner-Weiß G, Hansen PD et al (2000) Trends Analyt Chem 19:428–433Google Scholar
  205. 205.
    Oosterkamp AJ, Hock B, Seifert M, Irth H (1997) Trends Analyt Chem 16:544–553Google Scholar
  206. 206.
    Seifert M, Brenner-Weiss G, Haindl S, Nusser M, Obst U, Hock B (1999) Fresen J Anal Chem 363:767–770Google Scholar
  207. 207.
    Giera M, Irth H (2011) Simultaneous screening and chemical characterisation of bioactive compounds using LC-MS based technologies (affinity chromatography)Google Scholar
  208. 208.
    Eberz G, Rast H-G, Burger K, Kreiss W, Weisemann C (1996) Chromatographia 43:5–9Google Scholar
  209. 209.
    Schulz W, Seitz W, Weiss SC, Weber WH, Bohm M, Flottmann D (2008) J Planar Chromatogr Mod TLC 21:427–430Google Scholar
  210. 210.
    DellaGreca M, Fiorentino A, Iesce MR et al (2003) Environ Toxicol Chem 22:534–539Google Scholar
  211. 211.
    Reemtsma T (2001) Analyt Chim Acta 426:279–287Google Scholar
  212. 212.
    Holland LA, Jorgenson JW (1995) Anal Chem 67:3275–3283Google Scholar
  213. 213.
    Venkatramani CJ, Zelechonok Y (2003) Anal Chem 75:3484–3494Google Scholar
  214. 214.
    Murahashi T (2003) Analyst 128:42–45Google Scholar
  215. 215.
    Toriba A, Nakamura H, Chetiyanukornkul T et al (2003) Anal Biochem 312:14–22Google Scholar
  216. 216.
    Tian HZ, Xu J, Xu Y, Guan YF (2006) J Chromatogr A 1137:42–48Google Scholar
  217. 217.
    Wang Y, Lehmann R, Lu X, Zhao XJ, Xu GW (2008) J Chromatogr A 1204:28–34Google Scholar
  218. 218.
    Bobeldijk I, Brandt A, Wullings B, Noij T (2001) J Chromatogr A 918:277–291Google Scholar
  219. 219.
    Bobeldijk I, Stoks PGM, Vissers JPC et al (2002) J Chromatogr A 970:167–181Google Scholar
  220. 220.
    Fabel S, Niessner R, Weller MG (2005) J Chromatogr A 1099:103–110Google Scholar
  221. 221.
    Donnelly JR, Abdelhamid MS, Jeter JL, Gurka DF (1993) Application of gas-chromatographic retention properties to the identification of environmental contaminants. J Chromatogr 642(1–2):409–415Google Scholar
  222. 222.
    Eckel WP, Kind T (2003) Analyt Chim Acta 494:235–243Google Scholar
  223. 223.
    Schymanski EL, Bataineh M, Goss KU, Brack W (2009) Trends Analyt Chem 28:550–561Google Scholar
  224. 224.
    Abraham MH, Poole CF, Poole SK (1999) J Chromatogr A 842:79–114Google Scholar
  225. 225.
    Poole CF, Poole SK (2008) J Chromatogr A 1184:254–280Google Scholar
  226. 226.
    Callihan BK, Ballantine DS (2000) J Chromatogr A 893:339–346Google Scholar
  227. 227.
    Katritzky AR, Ignatchenko ES, Barcock RA, Lobanov VS, Karelson M (1994) Anal Chem 66:1799–1807Google Scholar
  228. 228.
    Garkani-Nejad Z, Karlovits M, Demuth W et al (2004) J Chromatogr A 1028:287–295Google Scholar
  229. 229.
    Korytar P, Leonards PEG, de Boer J, Brinkman UAT (2005) J Chromatogr A 1086:29–44Google Scholar
  230. 230.
    Phillips JB, Beens J (1999) J Chromatogr A 856:331–347Google Scholar
  231. 231.
    Currie LA, Eglinton TI, Benner J, Pearson A (1997) Nucl Instrum Methods B 123:475–486Google Scholar
  232. 232.
    Reddy CM, Pearson A, Xu L et al (2002) Environ Sci Technol 36:1774–1782Google Scholar
  233. 233.
    Mandalakis M, Gustafsson O, Reddy CM, Li X (2004) Environ Sci Technol 38:5344–5349Google Scholar
  234. 234.
    Eglinton TI, Aluwihare LI, Bauer JE, Druffel ERM, McNichol AP (1996) Anal Chem 68:904–912Google Scholar
  235. 235.
    Rethemeyer J, Kramer C, Gleixner G et al (2005) Geoderma 128:94–105Google Scholar
  236. 236.
    Holmstrand H, Mandalakis M, Zencak Z, Andersson P, Gustafsson O (2007) Chemosphere 69:1533–1539Google Scholar
  237. 237.
    Mandalakis M, Holmstrand H, Andersson P, Gustafsson Í (2008) Chemosphere 71:299–305Google Scholar
  238. 238.
    Teuten EL, Xu L, Reddy CM (2005) Science 307:917–920Google Scholar
  239. 239.
    Meinert C, Moeder M, Brack W (2007) Chemosphere 70:215–223Google Scholar
  240. 240.
    Pangallo K, Nelson RK, Teuten EL, Pedler BE, Reddy CM (2008) Chemosphere 71:1557–1565Google Scholar
  241. 241.
    Meinert C, Schymanski E, Küster E, Kühne R, Schüürmann G, Brack W (2010) Environ Sci Pollut Res 17:885–897Google Scholar
  242. 242.
    Meinert C, Brack W (2010) Chemosphere 78:416–422Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Department of Effect-Directed AnalysisUFZ Helmholtz Centre for Environmental ResearchLeipzigGermany
  2. 2.Department of Chemical EngineeringAbu Dhabi Men’s CollegeAbu DhabiUnited Arab Emirates

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