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Separation Techniques in Effect-Directed Analysis

  • Werner BrackEmail author
  • Nadin Ulrich
  • Mahmoud Bataineh
Chapter
Part of the The Handbook of Environmental Chemistry book series (HEC, volume 15)

Abstract

The continuous development of new chemicals enhances the complexity of environmental analysis and poses a risk to environmental and human health. Awareness is increasing that together with the chemical products on the market, the enormous number of transformation and by-products may contribute to this risk. Effect-directed analysis (EDA) has been developed to identify major toxicants in such complex mixtures. Separation techniques in EDA are applied to reduce the complexity of environmental mixtures and provide valuable information on physicochemical and thus structural properties of candidate toxicants. Within the last decades, separation science provided an extensive understanding of processes and mechanisms in chromatography, developed novel stationary phases with specific separation properties, and introduced modeling tools such as linear solvation energy relationships (LSER) to predict retention. A selection of these tools is compiled in the present paper to support the exploitation of present knowledge on chromatography to enhance the ability to identify so far unknown toxicants in complex mixtures.

Keywords

Fractionation LSER Mechanism QSRR Retention prediction Stationary phase 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Department of Effect-Directed AnalysisUFZ Helmholtz Centre for Environmental ResearchLeipzigGermany
  2. 2.Department of Chemical EngineeringAbu Dhabi Men’s CollegeAbu DhabiUnited Arab Emirates

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