Genetically Modified Mice: Useful Models to Study Cause and Effect of Cardiac Arrhythmias?

  • Gregor Sachse
  • Martin Kruse
  • Olaf Pongs


Genetically modified mice represent a tremendous advancement for studying effects of disease-related mutations in depth with the aim to enlighten molecular and physiological mechanisms underlying correlations between genotype and phenotype. Here we discuss some of the limitations that one may encounter with knockout, knockin and transgenic mice in the study of particular gene mutations related to human cardiac disease, with particular emphasis on channelopathies.


Ventricular Myocytes Cardiac Phenotype Ventricular Action Potential Mouse Ventricular Myocytes KCNH2 Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We gratefully acknowledge financial support of the Deutsche Forschungsgemeinschaft and the Fonds der Chemischen Industrie for the cardiovascular research in our laboratory.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Institut für Neurale SignalverarbeitungZMNH, University Hospital Hamburg-EppendorfHamburgGermany

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