Curvedness Study on Atherosclerosis Plaques and Its Implications to Plaque Stress

  • H. Gao
  • Q. Long
  • M. Graves
  • Z. Y. Li
  • J. H. Gillard
Conference paper

DOI: 10.1007/978-3-642-14515-5_384

Part of the IFMBE Proceedings book series (IFMBE, volume 31)
Cite this paper as:
Gao H., Long Q., Graves M., Li Z.Y., Gillard J.H. (2010) Curvedness Study on Atherosclerosis Plaques and Its Implications to Plaque Stress. In: Lim C.T., Goh J.C.H. (eds) 6th World Congress of Biomechanics (WCB 2010). August 1-6, 2010 Singapore. IFMBE Proceedings, vol 31. Springer, Berlin, Heidelberg

Abstract

Atherosclerosis plaque rupture has been considered to be a mechanical failure of the thin fibrous cap, resulted from extreme plaque stress. Plaque stress was affected by many factors from morphological features to biological abnormalities. In this study, geometrical factors (curvedness, fibrous cap thickness) were studied on assessing plaque vulnerability in comparison with stress analysis results obtained by fluid structure interaction from 20 human carotid atherosclerosis plaques. The results show that plaque surface curvedness could contribute to extreme stress level, especially in plaque shoulder region. General plaque stress distribution could be predicted by fibrous cap thickness and curvedness with multi-regression model. With more features included in the regression model, plaque stress could be easily calculated and used to assess plaque vulnerability.

Keywords

Atherosclerosis plaque stress analysis curvedness geometry features plaque vulnerability 

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Copyright information

© International Federation for Medical and Biological Engineering 2010

Authors and Affiliations

  • H. Gao
    • 1
  • Q. Long
    • 1
  • M. Graves
    • 2
  • Z. Y. Li
    • 2
  • J. H. Gillard
    • 2
  1. 1.Brunel Institute for BioengineeringBrunel UniversityUxbridgeUK
  2. 2.Department of RadiologyAddenbrooke’s HospitalCambridgeUK

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