Rhamnolipids: Detection, Analysis, Biosynthesis, Genetic Regulation, and Bioengineering of Production

  • Ahmad Mohammad Abdel-Mawgoud
  • Rudolf Hausmann
  • Francois Lépine
  • Markus M. Müller
  • Eric Déziel
Chapter
First Online:
Part of the Microbiology Monographs book series (MICROMONO, volume 20)

Abstract

As promising biotechnological products, rhamnolipids (RLs) are the most investigated biosurfactants. Over the years, important efforts have been spent and an array of techniques has been developed for the isolation of producing bacterial strains and the characterization of a large variety of RL homologs and congeners. Investigations on RL production by the best known producer, the opportunistic pathogen Pseudomonas aeruginosa, have shown that production of RLs proceeds through de novo biosynthesis of precursors. Over the last 15 years, the genetic details underlying RL production in P. aeruginosa have been mostly unraveled, revealing a complex regulatory mechanism controlled by quorum sensing pathways of intercellular communication. A number of nutritional and cultivation factors affecting RL productivity have also been identified, while the use of many affordable and renewable raw substrates has been described to optimize the production. Multidisciplinary approaches are increasingly adopted to develop methods for the safe, cost-effective, and highly efficient production of RLs at the industrial scale.

Keywords

High Performance Liquid Chromatography Quorum Sensing Solid State Fermentation Corn Steep Liquor Acyl Carrier Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Ahmad Mohammad Abdel-Mawgoud
    • 1
  • Rudolf Hausmann
    • 2
  • Francois Lépine
    • 1
  • Markus M. Müller
    • 2
  • Eric Déziel
    • 1
  1. 1.INRS-Institut Armand FrappierLavalCanada
  2. 2.Institute of Engineering in Life Sciences, Section of Technical BiologyResearch University KarlsruheKarlsruheGermany

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