Poly(n-butylcyanoacrylate) Submicron Particles Loaded with Ciprofloxacin for Potential Treatment of Bacterial Infections

Conference paper
Part of the Progress in Colloid and Polymer Science book series (PROGCOLLOID, volume 137)

Abstract

Poly(n-butylcyanoacrylate) submicron colloidal particles loaded with the antibiotic ciprofloxacin are prepared by emulsion polymerization and characterized by scanning electron microscopy, dynamic light scattering, nuclear magnetic resonance and gel-permeation chromatography. The entrapment efficiency for ciprofloxacin in the polymer particles is investigated as a function of the monomer and drug concentrations in the polymerization medium. The kinetics of ciprofloxacin release from the polymer particles is found to depend on the pH of the release medium. Studies by gel-permeation chromatography indicate for a possible drug-polymer association. The antibacterial activity of the obtained formulation is tested on a clinical isolate of Escherichia coli bacterium and is found to be similar to that of the free drug.

Keywords

poly(n-butylcyanoacrylate) colloids submicron particles ciprofloxacin drug release Escherichia coli 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Georgi Yordanov
    • 1
  • Nikola Abrashev
    • 2
  • Ceco Dushkin
    • 1
  1. 1.Laboratory of Nanoparticle Science and Technology, Department of General and Inorganic ChemistryFaculty of Chemistry, Sofia University ‘St.Kliment Ohridski’SofiaBulgaria
  2. 2.Microbiological LaboratoryMultiprofile Hospital for Active Treatment ‘Dr. Nikola Vasiliev’KyustendilBulgaria

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