Poly(n-butylcyanoacrylate) Submicron Particles Loaded with Ciprofloxacin for Potential Treatment of Bacterial Infections
Poly(n-butylcyanoacrylate) submicron colloidal particles loaded with the antibiotic ciprofloxacin are prepared by emulsion polymerization and characterized by scanning electron microscopy, dynamic light scattering, nuclear magnetic resonance and gel-permeation chromatography. The entrapment efficiency for ciprofloxacin in the polymer particles is investigated as a function of the monomer and drug concentrations in the polymerization medium. The kinetics of ciprofloxacin release from the polymer particles is found to depend on the pH of the release medium. Studies by gel-permeation chromatography indicate for a possible drug-polymer association. The antibacterial activity of the obtained formulation is tested on a clinical isolate of Escherichia coli bacterium and is found to be similar to that of the free drug.