Notes on the History of Caffeine Use

  • Bertil B. FredholmEmail author
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 200)


As behooves something so deeply entrenched in culture, the historical origins of the use of methylxanthines are unknown and dressed in myth. This is true for coffee as well as tea, and for both it is interesting to note that their common use is really very recent. For coffee we know that its use became more widespread in the fifteenth and sixteenth centuries, and in Europe this occurred in the eighteenth and nineteenth centuries. The use of tea became more common during the Ming Dynasty in China and during the eighteenth century in Britain. Coffee was mostly an upper-class drink in Arabia, and remained a relative luxury in Europe until quite recently. The use of other methylxanthine-containing beverages, such as maté, is even less well known. It is interesting to note that before these drinks were commonly used on a daily basis they were used for medicinal purposes, indicating that their pharmacological actions had long been noted.


Cocoa Coffee Maté Tea 


  1. Dinesen I (1937) Out of AfricaGoogle Scholar
  2. Coe SD, Coe MD (1996) The true history of chocolate. Thames and Hudson, LondonGoogle Scholar
  3. Cole J (1833) On the deleterious effects produced by drinking tea and coffee in excessive quantities. Lancet 2:274–278CrossRefGoogle Scholar
  4. Elgklou L (1993) Kaffeboken. Wiken, SverigeGoogle Scholar
  5. Ellis M (ed) (2007) Eighteenth-century coffee house culture. Pickering and Chatto, LondonGoogle Scholar
  6. Fischer E (1881a) Über das Caffein. Ber Dtsch Chem Ges 14:637–644CrossRefGoogle Scholar
  7. Fischer E (1881b) Über das Caffein. Zweite Mitteilung. Ber Dtsch Chem Ges 14:1905–1915CrossRefGoogle Scholar
  8. Fischer E (1882) Über das Caffein. Dritte Mitteilung. Ber Dtsch Chem Ges 15:29–33CrossRefGoogle Scholar
  9. Fischer E (1897) Über die Constitution des Caffeins, Xanthins. Hypoxanthins und verwandter Basen. Ber Dtsch Chem Ges 30:549–559CrossRefGoogle Scholar
  10. Hahnemann S (1803) Der Kaffee und seine Wirkungen. LeipzigGoogle Scholar
  11. Kakuzo O (2000) The book of tea (first published 1906), new edition. Barnes and Noble, BostonGoogle Scholar
  12. Lorenzetti D, Lorenzetti LR (1999) ‘Out of Africa’: Karen Blixen's coffee years. Tea and Coffee Trade Journal, 1 SeptGoogle Scholar
  13. Lu Y (1974) The classic of tea (translated and introduced by Francis Ross Carpenter). Brown, New JerseyGoogle Scholar
  14. Mair VH, Hoh E (2009) The true history of tea. Thames Hudson, LondonGoogle Scholar
  15. Nairon AF (1617) Referred to in Weinberg BA, Bealer BK (eds) De Saluberrimá Cabue seu Café nuncupata Discoursus. The World of Caffeine. Routledge, New York, 2001Google Scholar
  16. Prendergast M (1999) Uncommon grounds. The history of coffee and how it transformed our world. Basic Books, LondonGoogle Scholar
  17. Salter H (1860) Asthma: its pathology and treatment. Churchill, LondonGoogle Scholar
  18. Ukers WH (1922) All about coffee. The Tea and Coffee Trade Journal Company, New YorkGoogle Scholar
  19. Weinberg BA, Bealer BK (2001) The world of caffeine. The science and culture of the world’s most popular drug. Routledge, New YorkGoogle Scholar

Copyright information

© Springer Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Department of Physiology and PharmacologyKarolinska InstituteStockholmSweden

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