A Comparative Study of Microarray Data Classification Methods Based on Ensemble Biological Relevant Gene Sets

  • Miguel Reboiro-Jato
  • Daniel Glez-Peña
  • Juan Francisco Gálvez
  • Rosalía Laza Fidalgo
  • Fernando Díaz
  • Florentino Fdez-Riverola
Part of the Advances in Intelligent and Soft Computing book series (AINSC, volume 74)

Abstract

In this work we study the utilization of several ensemble alternatives for the task of classifying microarray data by using prior knowledge known to be biologically relevant to the target disease. The purpose of the work is to obtain an accurate ensemble classification model able to outperform baseline classifiers by introducing diversity in the form of different gene sets. The proposed model takes advantage of WhichGenes, a powerful gene set building tool that allows the automatic extraction of lists of genes from multiple sparse data sources. Preliminary results using different datasets and several gene sets show that the proposal is able to outperform basic classifiers by using existing prior knowledge.

Keywords

microarray data classification ensemble classifiers gene sets prior knowledge 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Miguel Reboiro-Jato
    • 1
  • Daniel Glez-Peña
    • 1
  • Juan Francisco Gálvez
    • 1
  • Rosalía Laza Fidalgo
    • 1
  • Fernando Díaz
    • 2
  • Florentino Fdez-Riverola
    • 1
  1. 1.ESEI: Escuela Superior de Ingeniería InformáticaUniversity of Vigo, Edificio PolitécnicoOurenseSpain
  2. 2.EUI: Escuela Universitaria de InformáticaUniversity of ValladolidSegoviaSpain

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