Bioorganometallic Chemistry and Malaria

Part of the Topics in Organometallic Chemistry book series (TOPORGAN, volume 32)

Abstract

This chapter summarizes recent developments in the design, synthesis, and structure–activity relationship studies of organometallic antimalarials. It begins with a general introduction to malaria and the biology of the parasite Plasmodium falciparum, with a focus on the heme detoxification system. Then, a number of metal complexes from the literature are reported for their antiplasmodial activity. The second half of the chapter deals with the serendipitous discovery of ferroquine, its mechanism(s) of action, and the failure to induce a resistance. Last, but not least, we suggest that the bioorganometallic approach offers the potential for the design of novel therapeutic agents.

Keywords

Antimalarial Bioorganometallic Drug resistance ferroquine 

Notes

Acknowledgments

We would like to thank Prof. Gérard Jaouen and Prof. Nils Metzler-Nolte for their kind support. We thank Faustine Dubar for the schematic representation of the malaria parasite. Melissa Ladyman is acknowledged for proof-reading the manuscript.

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© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  1. 1.Unité de Catalyse et de Chimie du Solide – UMR CNRS 8181, ENSCLUniversité de Lille 1Villeneuve d’Ascq cedexFrance
  2. 2.Unité de Glycobiologie Structurale et Fonctionnelle – UMR CNRS 8576Université de Lille 1Villeneuve d’Ascq cedexFrance
  3. 3.Inserm U547, Institut PasteurUniversité Lille Nord de FranceLille cedexFrance

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