Calcium Homeostasis and Acidocalcisomes in Trypanosoma cruzi

  • Paul Ulrich
  • Roxana Cintrón
  • Roberto DocampoEmail author
Part of the Microbiology Monographs book series (MICROMONO, volume 17)


Calcium ion (Ca2+) is an important second messenger in Trypanosoma cruzi and is essential for invasion of host cells by this parasite. A number of transporters and channels in the plasma membrane, endoplasmic reticulum, and mitochondria regulate cytosolic calcium concentration. Additionally, the T. cruzi genome contains a wide variety of signaling and regulatory proteins that bind calcium as well as many putative calcium-binding proteins that await further characterization. In T. cruzi, acidic organelles known as acidocalcisomes are the primary reservoir of intracellular calcium and mediate polyphosphate metabolism, osmoregulation, and calcium and pH homeostasis.


Trypanosoma Cruzi Nicotinic Acid Adenine Dinucleotide Phosphate InsP3 Receptor Bloodstream Trypomastigotes Short Chain Polyphosphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.





Cyclic ADP ribose


Calcium ion


Cytosolic Ca2+ concentration




Ca2+/calmodulin dependent kinase


Calcium induced calcium release




Flagellar calcium binding protein


Inositol 1,4,5-trisphosphate


InsP3 receptor


Nicotinic acid adenine dinucleotide phosphate


Phosphatidylinositol 4,5-bisphosphate


Phosphatidylinositol phospholipase C


Plasma membrane Ca2+-ATPase

poly P



Ryanodine receptor


Sarcoplasmic-endoplasmic reticulum Ca2+-ATPase


Vacuolar proton ATPase


Vacuolar proton pyrophosphatase


Vacuolar transporter chaperone



This work was supported in part by a postdoctoral fellowship from the American Heart Association (to PU), grant AI-068647 from the National Institutes of Allergy and Infectious Diseases, U.S. National Institutes of Health (NIH) (to RD), and by a NIH Research Supplement to grant AI-068467, to Promote Diversity in Health-Related Research (to RC).


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© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  1. 1.Center for Tropical and Emerging Global Diseases and Department of Cellular BiologyUniversity of GeorgiaAthensUSA

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