Alloantigene auf Granulozyten

  • J. Bux
Chapter

Zusammenfassung

Die bekanntesten polymorphen und immunogenen Strukturen auf der Zellmembran von Leukozyten sind die Antigene des HLA-Systems. Darüber hinaus konnten auf Granulozyten zahlreiche antigene Strukturen biochemisch, molekularbiologisch und funktionell charakterisiert werden. Zur besseren Systematisierung wurde für diese die HNA-Nomenklatur (humane neutrophile Alloantigene), eingeführt und die Antigene entsprechend neu benannt. Den HNA-Antigenen kommt eine wichtige Rolle bei der Induktion von Allo- und Autoantikörpern zu, die zu schwerwiegenden Immunneutropenien und lebensbedrohlichen Transfusionsreaktionen führen können.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • J. Bux
    • 1
  1. 1.DRK-Blutspendedienst West gemeinnützige GmbHHagen

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