The Informative Extremes: Using Both Nearest and Farthest Individuals Can Improve Relief Algorithms in the Domain of Human Genetics
A primary goal of human genetics is the discovery of genetic factors that influence individual susceptibility to common human diseases. This problem is difficult because common diseases are likely the result of joint failure of two or more interacting components instead of single component failures. Efficient algorithms that can detect interacting attributes are needed. The Relief family of machine learning algorithms, which use nearest neighbors to weight attributes, are a promising approach. Recently an improved Relief algorithm called Spatially Uniform ReliefF (SURF) has been developed that significantly increases the ability of these algorithms to detect interacting attributes. Here we introduce an algorithm called SURF* which uses distant instances along with the usual nearby ones to weight attributes. The weighting depends on whether the instances are are nearby or distant. We show this new algorithm significantly outperforms both ReliefF and SURF for genetic analysis in the presence of attribute interactions. We make SURF* freely available in the open source MDR software package. MDR is a cross-platform Java application which features a user friendly graphical interface.
KeywordsEpistatic Interaction Genetic Association Study Sporadic Breast Cancer Wellcome Trust Case Control Consortium Distant Individual
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