Biotin-Streptavidin Sensitive BioFETs and Their Properties

  • Thomas Windbacher
  • Viktor Sverdlov
  • Siegfried Selberherr
Part of the Communications in Computer and Information Science book series (CCIS, volume 52)


In this work the properties of a biotin-streptavidin BioFET have been studied numerically with homogenized boundary interface conditions as the link between the oxide of the FET and the analyte which contains the bio-sample. The biotin-streptavidin reaction pair is used in purification and detection of various biomolecules; the strong streptavidin-biotin bond can also be used to attach biomolecules to one another or onto a solid support. Thus this reaction pair in combination with a FET as the transducer is a powerful setup enabling the detection of a wide variety of molecules with many advantages that stem from the FET, like no labeling, no need of expensive read-out devices, the possibility to put the signal amplification and analysis on the same chip, and outdoor usage without the necessity of a lab.


Dipole Moment Output Curve Drain Current Reaction Pair Molecule Orientation 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Thomas Windbacher
    • 1
  • Viktor Sverdlov
    • 1
  • Siegfried Selberherr
    • 1
  1. 1.Institute for MicroelectronicsTU WienWienAustria

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