Multi-analytical Approaches Informing the Risk of Sepsis

  • Femida Gwadry-Sridhar
  • Benoit Lewden
  • Selam Mequanint
  • Michael Bauer
Conference paper
Part of the Communications in Computer and Information Science book series (CCIS, volume 52)


Sepsis is a significant cause of mortality and morbidity and is often associated with increased hospital resource utilization, prolonged intensive care unit (ICU) and hospital stay. The economic burden associated with sepsis is huge. With advances in medicine, there are now aggressive goal oriented treatments that can be used to help these patients. If we were able to predict which patients may be at risk for sepsis we could start treatment early and potentially reduce the risk of mortality and morbidity. Analytic methods currently used in clinical research to determine the risk of a patient developing sepsis may be further enhanced by using multi-modal analytic methods that together could be used to provide greater precision. Researchers commonly use univariate and multivariate regressions to develop predictive models. We hypothesized that such models could be enhanced by using multiple analytic methods that together could be used to provide greater insight. In this paper, we analyze data about patients with and without sepsis using a decision tree approach and a cluster analysis approach. A comparison with a regression approach shows strong similarity among variables identified, though not an exact match. We compare the variables identified by the different approaches and draw conclusions about the respective predictive capabilities,while considering their clinical significance.


Intensive Care Unit Decision Tree Septic Shock Severe Sepsis Intensive Care Unit Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Femida Gwadry-Sridhar
    • 1
  • Benoit Lewden
    • 1
  • Selam Mequanint
    • 1
  • Michael Bauer
    • 2
  1. 1.Lawson Health Research Institute, I-THINK Research LabLondonCanada
  2. 2.Department of Computer ScienceUniversity of Western OntarioLondonCanada

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