LASTIC: A Light Aspiration Device for in vivo Soft TIssue Characterization

  • Patrick Schiavone
  • Emmanuel Promayon
  • Yohan Payan
Part of the Lecture Notes in Computer Science book series (LNCS, volume 5958)


This paper introduces a new Light Aspiration device for in vivo Soft TIssue Characterization (LASTIC). This device is designed to be used during surgery, and can undergo sterilization. It provides interactive-time estimation of the elastic parameters. LASTIC is a 3cm x 3cm metallic cylinder divided in two compartments. The lower compartment is a cylindrical chamber made airtight by a glass window in which a negative pressure can be applied. Put in contact with soft tissues, it can aspirate the tissues into the chamber through a circular aperture in its bottom side. The upper compartment is clinched onto the lower part. A miniature digital camera is fixed inside the upper chamber, focusing on the aspirated soft tissue. LASTIC is operated by applying a range of negative pressures in the lower compartment while measuring the resulting aspirated tissue deformations with the digital camera. These measurements are used to estimate the tissue elasticity parameters by inverting a Finite Element model of the suction experiment. In order to use LASTIC during surgical interventions, a library-based optimization process is used to provide an interactive time inversion.


Negative Pressure Suction Device Computer Assist Surgery Human Soft Tissue Miniature Camera 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Ottensmeyer, M.P.: Minimally invasive instrument for in vivo measurement of solid organ mechanical impedance. PhD thesis, Massachusetts Institute of Technology. Dept. of Mechanical Engineering (2001)Google Scholar
  2. 2.
    Gefen, A., Margulies, S.: Are in vivo and in situ brain tissues mechanically similar? J. Biomech. 37(9), 1339–1352 (2004)CrossRefGoogle Scholar
  3. 3.
    Kerdok, A.E., Ottensmeyer, M.P., Howe, R.D.: Effects of perfusion on the viscoelastic characteristics of liver. J. Biomech. 39(12), 2221–2231 (2006)CrossRefGoogle Scholar
  4. 4.
    Carter, F.J., Frank, T.G., Davies, P.J., McLean, D., Cuschieri, A.: Measurements and modelling of the compliance of human and porcine organs. Med. Image Anal. 5(4), 231–236 (2001)CrossRefGoogle Scholar
  5. 5.
    Samur, E., Sedef, M., Basdogan, C., Avtan, L., Duzgun, O.: A robotic indenter for minimally invasive measurement and characterization of soft tissue response. Med. Image Anal. 11(4), 361–373 (2007)CrossRefGoogle Scholar
  6. 6.
    Agache, P.G., Monneur, C., Leveque, J.L., Rigal, J.D.: Mechanical properties and young’s modulus of human skin in vivo. Arch. Dermatol. Res. 269(3), 221–232 (1980)CrossRefGoogle Scholar
  7. 7.
    Jemec, G.B., Selvaag, E., Agren, M., Wulf, H.C.: Measurement of the mechanical properties of skin with ballistometer and suction cup. Skin Res. Technol. 7(2), 122–126 (2001)CrossRefGoogle Scholar
  8. 8.
    Grahame, R., Holt, P.J.: The influence of ageing on the in vivo elasticity of human skin. Gerontologia 15(2), 121–139 (1969)CrossRefGoogle Scholar
  9. 9.
    Vuskovic, V.: Device for in-vivo measurement of mechanical properties of internal human soft tissues. PhD thesis, ETH Zürich (2001)Google Scholar
  10. 10.
    Diridollou, S., Patat, F., Gens, F., Vaillant, L., Black, D., Lagarde, J.M., Gall, Y., Berson, M.: In vivo model of the mechanical properties of the human skin under suction. Skin Res. Technol. 6(4), 214–221 (2000)CrossRefGoogle Scholar
  11. 11.
    Mazza, E., Nava, A., Bauer, M., Winter, R., Bajka, M., Holzapfel, G.A.: Mechanical properties of the human uterine cervix: an in vivo study. Med. Image Anal. 10(2), 125–136 (2006)CrossRefGoogle Scholar
  12. 12.
    Wang, Q., Kong, L., Sprigle, S., Hayward, V.: Portable gage for pressure ulcer detection. In: Engineering in Medicine and Biology Society, 2006. EMBS 2006. 28th Annual International Conference of the IEEE, pp. 5997–6000 (2006)Google Scholar
  13. 13.
    Nava, A., Mazza, E., Furrer, M., Villiger, P., Reinhart, W.H.: In vivo mechanical characterization of human liver. Med. Image Anal. 12(2), 203–216 (2008)CrossRefGoogle Scholar
  14. 14.
    Schiavone, P., Chassat, F., Boudou, T., Promayon, E., Valdivia, F., Payan, Y.: In vivo measurement of human brain elasticity using a light aspiration device. Med. Image Anal. 13, 673–678 (2009)CrossRefGoogle Scholar
  15. 15.
    Niu, X., Jakatdar, N., Bao, J., Spanos, C.J.: Specular spectroscopic scatterometry. IEEE Transactions on Semiconductor Manufacturing 14(2), 97–111 (2001)CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Patrick Schiavone
    • 1
    • 2
  • Emmanuel Promayon
    • 2
  • Yohan Payan
    • 2
    • 3
  1. 1.Laboratoire des Technologies de la Microelectronique CNRSGrenobleFrance
  2. 2.TIMC-IMAG LaboratoryUMR CNRS 5525 and University Joseph Fourier, Pavillon Taillefer, Faculte de MedecineLa TroncheFrance
  3. 3.PIMSUMI CNRS 3069, University of British ColumbiaVancouverCanada

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