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The Laron Mouse

  • John J. KopchickEmail author
  • John D. Blischak
Chapter

Core Message

Studies of GHR−/− mice have helped to reveal the role of GH in many physiological processes such as reproduction, growth, GH/IGF-1 feedback loops to the pituitary, insulin and glucose metabolism, longevity, and obesity. This mouse model has also been used to investigate in vivo intracellular signaling systems specific for the GH/GHR interaction. Additionally, these mice have been and continue to be used to study disease states in which GH has been implicated in the pathophysiology of the disease such as Type 1 diabetes and certain cancers. In the following sections, we will elaborate on these findings, and where possible, point out similarities/differences between results found in mice versus human LS individuals.

Keywords

Luteinizing Hormone Wild Type Control Luteinizing Hormone Receptor Laron Syndrome Female Heterozygote 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Edison Biotechnology Institute and Department of Biomedical SciencesOhio UniversityAthensUSA

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