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Irreversible Electroporation Systems for Clinical Use

  • Claudio Bertacchini
  • Pier Mauro Margotti
  • Enrico Bergamini
  • Mattia Ronchetti
  • Ruggero Cadossi
Part of the Series in Biomedical Engineering book series (BIOMENG)

Abstract

Electroporation is a technique that uses micro to milliseconds electric pulses to create pores in the cell membrane, thus allowing molecules that, due to their physical and/or chemical properties, would normally not be able to cross the cell membrane, to enter the cell (1-5). Electroporation finds applications in many fields in particular for gene insertion in cells (electrogenetherapy) (6,7) and for the treatment of cancer (electrochemotherapy). In electrochemotherapy, the combination of chemotherapy and electroporation of tumour cells, the effects of drugs that usually show little cytotoxicity are greatly increased (8). The opening of pores in the cell membrane allows the chemotherapeutic agent to enter the cell at greater, more effective concentration and exert its cytotoxic action by killing the target cell (9-11).

Keywords

Graphical User Interface Power Unit Irreversible Electroporation Pulse Transformer High Voltage Generator 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Claudio Bertacchini
    • 1
  • Pier Mauro Margotti
    • 1
  • Enrico Bergamini
    • 1
  • Mattia Ronchetti
    • 1
  • Ruggero Cadossi
    • 1
  1. 1.IGEA S.p.A.CarpiItaly

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