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Synthetic Promoter Engineering

  • M. Venter
  • F. C. Botha
Chapter

Abstract

Despite the rapid progress as a result of high-throughput platforms, computational assistance and emerging technologies such as virus induced gene silencing (VIGS) and RNA interference (RNAi), targeted control of transgene activity remains probably the major stumbling block in successful application of gene modification technology in plants. The widespread failure of using current conventional strategies to find and optimize the use of wild-type promoters to attain specific biotechnological applications in transgenic plants has fuelled rapid developments in the design and optimization of synthetic engineered promoters. This chapter analyses the current status of synthetic promoter design and development and highlights factors that are still limiting progress in this area. Synthetic promoters are undoubtedly powerful molecular tools and, with the flexibility of gene control that can be achieved through design strategies, there can be little doubt that this kind of promoter will contribute significantly to future biotechnology applications and elucidation of gene function in basic research.

Keywords

Core Promoter Aryl Hydrocarbon Receptor Bidirectional Promoter Virus Induce Gene Silence Synthetic Promoter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  1. 1.Department of GeneticsStellenbosch UniversityMatielandSouth Africa
  2. 2.BSESIndooroopillyAustralia
  3. 3.Institute for Plant BiotechnologyStellenbosch UniversityMatielandSouth Africa

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