Particle Based Shape Regression of Open Surfaces with Applications to Developmental Neuroimaging

  • Manasi Datar
  • Joshua Cates
  • P. Thomas Fletcher
  • Sylvain Gouttard
  • Guido Gerig
  • Ross Whitaker
Part of the Lecture Notes in Computer Science book series (LNCS, volume 5762)

Abstract

Shape regression promises to be an important tool to study the relationship between anatomy and underlying clinical or biological parameters, such as age. In this paper we propose a new method to building shape models that incorporates regression analysis in the process of optimizing correspondences on a set of open surfaces. The statistical significance of the dependence is evaluated using permutation tests designed to estimate the likelihood of achieving the observed statistics under numerous rearrangements of the shape parameters with respect to the explanatory variable. We demonstrate the method on synthetic data and provide a new results on clinical MRI data related to early development of the human head.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Manasi Datar
    • 1
  • Joshua Cates
    • 1
  • P. Thomas Fletcher
    • 1
  • Sylvain Gouttard
    • 1
  • Guido Gerig
    • 1
  • Ross Whitaker
    • 1
  1. 1.Scientific Computing and Imaging InstituteUniversity of UtahSalt Lake CityUtah

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