Evolutionary Parameters in Sequence Families

Cold Adaptation of Enzymes
  • Said Hassan Ahmed
  • Tor Flå
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 5780)


In an attempt to incorporate environmental effects like cold-adaptation into models of sequence evolution on a phylogenetic tree, we present a viable way of representing descriptive statistics of sequence observables under reversible Markov models of sequence evolution. Local variation in amino acid distribution along and across the sequence family can be connected to enzymatic adaptation to different temperatures. Here, we estimate a few amino acid properties and how the variations of these properties both with respect excess mean values (EMVs) and covariance classify the protein family into clusters. Application of a multiscale and multivariate method to an aligned family of distinct trypsin and elastase sequences shows drift of centroid mean sequences of cold adapted enzymes compared to their warm-active counterparts.


Discrete Wavelet Trans Sequence Position Evolutionary Parameter Cold Adaptation Sequence Family 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Said Hassan Ahmed
    • 1
  • Tor Flå
    • 1
  1. 1.Dept of Mathematics and StatisticsUniversity of TromsøTromsøNorway

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