Remote Controlled Drug Release Induced by a Rotating Magnetic Field

Abstract

A novel type of a medical capsule is described which is suitable to perform remote controlled drug release at predetermined positions in the gastrointestinal tract without the use of ionizing radiation. This capsule is based on magnetically generated heating effects and completely consists of biocompatible parts. Theoretical estimations show that the maximum depth of the capsule below the abdominal wall (range of operation) is mainly ruled by the weight and the cautionary conditions of a spinning magnet needed for the thermally produced drug ejection. In vitro experiments confirmed the theoretical predictions. A maximum depth of about 12 cm for ambulatory measuring units and of about 20 cm for stationary units, respectively, can be expected.