Immunological Synapses Within Context: Patterns of Cell–Cell Communication and Their Application in T–T Interactions
The cell-biology of intercellular communication between T cells and their partners has been greatly advanced over the past 10 years. The key morphological and motility features of cell contact-based communication between T cells and APCs can now be seen as a collection of patterns for cell–cell interactions amongst immune cells more generally, each serving to contribute to the outcome of the contact both locally and globally. Here we review the conservation of these patterns, amongst which is the emergent “immunological synapse,” and describe a newly defined example, formed between the adjacent activating T cells. We subsequently seek to put these and the pattern more generally into the framework of system-wide behavior of the immune system. We postulate that the patterns are fine-tuned to provide quorum-like decisions by collections of activating and activated cells that interact over time and space.
JD was supported by the Korea Science and Engineering Foundation (KOSEF) NCRC grant funded by the Korea government (MEST) (No. R15-2004-033-06002-0) MFK was supported by funding from the Sandler family fund, the JDRF and the Leukemia and Lymphoma Society. We thank Peter Beemiller for the critical reading, and Miju Kim for assistance with graphics.
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