Nonself Detection in a Two-Component Cellular Frustrated System
The cellular frustration concept was first introduced in an ICARIS conference  as an alternative approach to accomplish specific and prompt intrusion detection in highly diverse systems. Cellular frustration uses two main assumptions: 1) that cells’ activation are better modeled as cellular decisions and 2) that these cells’ decisions require a finite amount of time to be triggered. These two assumptions have been gaining experimental support. It is now well established that T cells activation requires a considerable amount of time . Experimental observations also suggest that interactions of T cells with APCs could be better modeled as cellular decisions rather than conventional probabilistic reactions ,. As a result from these assumptions the cellular frustration framework (CFF) is capable of reconciling two apparently opposing phenomena, namely high reactivity against nonself with total tolerance towards self .
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