Raman Spectroscopy: A Tool for Tissue Engineering

Chapter

Abstract

Raman spectroscopy can offer a non-invasive, information-rich biochemical “snapshot” of living human cells, tissues or material-cell tissue constructs rapidly(seconds–minutes), without the need of labels or contrast enhancers. This chapter details the exciting potential and challenges associated with the use of Raman spectroscopy in tissue engineering (TE). The use of Raman spectroscopy in three interlinked areas of TE will be considered: (1) the characterisation of the various scaffolds and “smart” materials, (2) the biochemical analysis of cellular behaviour important in TE (e.g. differentiation) and (3) the use of Raman spectroscopy for the analysis of tissue/extracellular matrix (ECM) formation in vitro or possibly in vivo.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. [1]
    M.M. Stevens, J.H. George, Science 310, 1135 (2005)CrossRefADSGoogle Scholar
  2. [2]
    H. Shin, S. Jo, A.G. Mikos, Biomaterials 24, 4353 (2003)CrossRefGoogle Scholar
  3. [3]
    R.J. Swain, Non-invasive biochemical analysis of cells, tissues and tissue constructs with Raman spectroscopy. PhD Thesis, Imperial College, London, 2008Google Scholar
  4. [4]
    I. Notingher, G. Jell, P.L. Notingher, I. Bisson, O. Tsigkou, J.M. Polak, M.M. Stevens, L.L. Hench, J. Mol. Struct. 744–747, 179 (2005)CrossRefGoogle Scholar
  5. [5]
    J.W. Dobrucki, D. Feret, A. Noatynska, Biophys. J. 93, 1778 (2007)CrossRefADSGoogle Scholar
  6. [6]
    K. Faulds, R.P. Barbagallo, J.T. Keer, W.E. Smith, D. Graham, Analyst 129, 567 (2004)CrossRefADSGoogle Scholar
  7. [7]
    A.D. Meade, F.M. Lyng, P. Knief, H.J. Byrne, Anal. Bioanal. Chem. 387, 1717 (2007)CrossRefGoogle Scholar
  8. [8]
    C. Krafft, D. Codrich, G. Pelizzo, V. Sergo, Analyst 133, 361 (2008)CrossRefADSGoogle Scholar
  9. [9]
    A. Boskey, C.N. Pleshko, Biomaterials 28, 2465 (2007)CrossRefGoogle Scholar
  10. [10]
    C. Delogne, P.V. Lawford, S.M. Habesch, V.A. Carolan, J. Microsc. 228, 62 (2007)CrossRefMathSciNetGoogle Scholar
  11. [11]
    H.J. van Manen, Y.M. Kraan, D. Roos, C. Otto, J. Phys. Chem. B 108, 18762 (2004)CrossRefGoogle Scholar
  12. [12]
    S.O. Konorov, C.H. Glover, J.M. Piret, J. Bryan, H.G. Schulze, M.W. Blades, R.F. Turner, Anal. Chem. 79, 7221 (2007)CrossRefGoogle Scholar
  13. [13]
    D. Naumann, in Infrared and Raman Spectroscopy of Biological Materials, ed. by H.-U. Gremlich, B. Yan (Marcel Dekker, New York, 2001), p. 323Google Scholar
  14. [14]
    P.R. Carey, Q. Rev. Biophys. 11, 309 (1978)CrossRefGoogle Scholar
  15. [15]
    A.G. Ryder, Curr. Opin. Chem. Biol. 9, 489 (2005)CrossRefGoogle Scholar
  16. [16]
    L.G. Rodriguez, S.J. Lockett, G.R. Holtom, Cytometry A 69, 779 (2006)Google Scholar
  17. [17]
    A.S. Curtis, M. Varde, J. Natl. Cancer Inst. 33, 15 (1964)Google Scholar
  18. [18]
    M.J. Dalby, N. Gadegaard, R. Tare, A. Andar, M.O. Riehle, P. Herzyk, C.D. Wilkinson, R.O. Oreffo, Nat. Mater. 6, 997 (2007)CrossRefADSGoogle Scholar
  19. [19]
    A. Bertoluzza, C. Fagnano, P. Monti, R. Simoni, A. Tinti, M.R. Tosi, R. Caramazza, Clin. Mater. 9, 49 (1992)CrossRefGoogle Scholar
  20. [20]
    J.J. Blaker, J.E. Gough, V. Maquet, I. Notingher, A.R. Boccaccini, J. Biomed. Mater. Res. A 67, 1401 (2003)CrossRefGoogle Scholar
  21. [21]
    T. Van Sr., A. Mens, C.F. van Nostrum, W.E. Hennink, Biomacromolecules 9, 158 (2008)CrossRefGoogle Scholar
  22. [22]
    M.H. Chowdhury, V.A. Gant, A. Trache, A. Baldwin, G.A. Meininger, G.L. Cote, J. Biomed. Opt. 11, 024004 (2006)CrossRefADSGoogle Scholar
  23. [23]
    R.M. Jarvis, E.W. Blanch, A.P. Golovanov, J. Screen, R. Goodacre, Analyst 132, 1053 (2007)CrossRefADSGoogle Scholar
  24. [24]
    G.M. Walsh, D. Leane, N. Moran, T.E. Keyes, R.J. Forster, D. Kenny, S. O’Neill, Biochemistry 46, 6429 (2007)CrossRefGoogle Scholar
  25. [25]
    S. Keren, C. Zavaleta, Z. Cheng, Z.A. de la, O. Gheysens, S.S. Gambhir, Proc. Natl. Acad. Sci. U S A 105, 5844 (2008)CrossRefADSGoogle Scholar
  26. [26]
    Z. Liu, C. Davis, W. Cai, L. He, X. Chen, H. Dai, Proc. Natl. Acad. Sci. U S A 105, 1410 (2008)CrossRefADSGoogle Scholar
  27. [27]
    A. Carden, M.D. Morris, J. Biomed. Opt. 5, 259 (2000)CrossRefADSGoogle Scholar
  28. [28]
    W.L. Rice, S. Firdous, S. Gupta, M. Hunter, C.W. Foo, Y. Wang, H.J. Kim, D.L. Kaplan, I. Georgakoudi, Biomaterials 29, 2015 (2008)CrossRefGoogle Scholar
  29. [29]
    S.T. Nandagawali, J.S. Yerramshetty, O. Akkus, J. Biomed. Mater. Res. A 82, 611 (2007)Google Scholar
  30. [30]
    A.A. van Apeldoorn, H.J. van Manen, J.M. Bezemer, J.D. de Bruijn, C.A. van Blitterswijk, C. Otto, J. Am. Chem. Soc. 126, 13226 (2004)CrossRefGoogle Scholar
  31. [31]
    I. Notingher, S. Verrier, S. Haque, J.M. Polak, L.L. Hench, Biopolymers 72, 230 (2003)CrossRefGoogle Scholar
  32. [32]
    I. Notingher, C. Green, C. Dyer, E. Perkins, N. Hopkins, C. Lindsay, L.L. Hench, J. R. Soc. Interface 1, 79 (2004)CrossRefGoogle Scholar
  33. [33]
    C.A. Owen, J. Selvakumaran, I. Notingher, G. Jell, L.L. Hench, M.M. Stevens, J. Cell Biochem. 99, 178 (2006)Google Scholar
  34. [34]
    K.W. Short, S. Carpenter, J.P. Freyer, J.R. Mourant, Biophys. J. 88, 4274 (2005)CrossRefGoogle Scholar
  35. [35]
    C. Matthäus, S. Boydston-White, M. Miljkovic, M. Romeo, M. Diem, Appl. Spectrosc. 60, 1 (2006)CrossRefADSGoogle Scholar
  36. [36]
    R.J. Swain, G. Jell, M.M. Stevens, J. Cell Biochem. 104, 1427 (2008)Google Scholar
  37. [37]
    I. Notingher, I. Bisson, A.E. Bishop, W.L. Randle, J.M. Polak, L.L. Hench, Anal. Chem. 76, 3185 (2004)CrossRefGoogle Scholar
  38. [38]
    G. Jell, I. Notingher, O. Tsigkou, P. Notingher, J.M. Polak, L.L. Hench, M.M. Stevens, J. Biomed. Mater. Res. A 86, 31 (2008)Google Scholar
  39. [39]
    R.J. Swain, S.J. Kemp, P. Goldstraw, T.D. Tetley, M.M. Stevens, Biophys. J. 95, 5978–5987 (2008)CrossRefADSGoogle Scholar
  40. [40]
    J.E. Gough, I. Notingher, L.L. Hench, J. Biomed. Mater. Res. A 68, 640 (2004)CrossRefGoogle Scholar
  41. [41]
    J.R. Jones, A. Vats, I. Notingher, J.E. Gough, N.S. Tolley, J.M. Polak, L.L. Hench, Key Eng. Mater. 623 {284–286}, (2005)Google Scholar
  42. [42]
    I. Notingher, G. Jell, U. Lohbauer, V. Salih, L.L. Hench, J. Cell Biochem. 92, 1180 (2004)Google Scholar
  43. [43]
    P. Crow, B. Barrass, C. Kendall, M. Hart-Prieto, M. Wright, R. Persad, N. Stone, Br. J. Cancer 92, 2166 (2005)CrossRefGoogle Scholar
  44. [44]
    P.J. Caspers, G.W. Lucassen, G.J. Puppels, Biophys. J. 85, 572 (2003)CrossRefADSGoogle Scholar
  45. [45]
    A. Tfayli, O. Piot, F. Draux, F. Pitre, M. Manfait, Biopolymers 87, 261 (2007)CrossRefGoogle Scholar
  46. [46]
    C. Krafft, S.B. Sobottka, G. Schackert, R. Salzer, Analyst 130, 1070 (2005)CrossRefADSGoogle Scholar
  47. [47]
    S. Koljenovic, T.C. Bakker Schut, J.P. van Meerbeeck, A.P. Maat, S.A. Burgers, P.E. Zondervan, J.M. Kros, G.J. Puppels, J. Biomed. Opt. 9, 1187 (2004)CrossRefADSGoogle Scholar
  48. [48]
    M.A. Short, S. Lam, A. McWilliams, J. Zhao, H. Lui, H. Zeng, Opt. Lett. 33, 711 (2008)CrossRefADSGoogle Scholar
  49. [49]
    C. Krafft, R. Salzer, G. Soff, M. Meyer-Hermann, Cytometry A 64, 53 (2005)Google Scholar
  50. [50]
    H. Wang, Y. Fu, P. Zickmund, R. Shi, J.X. Cheng, Biophys. J. 89, 581 (2005)CrossRefGoogle Scholar
  51. [51]
    M. Heger, S. Mordon, G. Leroy, L. Fleurisse, C. Creusy, J. Biomed. Opt. 11, 024003 (2006)CrossRefADSGoogle Scholar
  52. [52]
    E.R. Draper, M.D. Morris, N.P. Camacho, P. Matousek, M. Towrie, A.W. Parker, A.E. Goodship, J. Bone Miner. Res. 20, 1968 (2005)CrossRefGoogle Scholar
  53. [53]
    M.V. Schulmerich, J.H. Cole, K.A. Dooley, M.D. Morris, J.M. Kreider, S.A. Goldstein, S. Srinivasan, B.W. Pogue, J. Biomed. Opt. 13, 020506 (2008)CrossRefADSGoogle Scholar
  54. [54]
    M.R. Towler, A. Wren, N. Rushe, J. Saunders, N.M. Cummins, P.M. Jakeman, J. Mater. Sci. Mater. Med. 18, 759 (2007)CrossRefGoogle Scholar
  55. [55]
    A.A. van Apeldoorn, Y. Aksenov, M. Stigter, I. Hofland, J.D. de Bruijn, H.K. Koerten, C. Otto, J. Greve, C.A. van Blitterswijk, J. R. Soc. Interface. 2, 39 (2005)CrossRefGoogle Scholar
  56. [56]
    B.R. McCreadie, M.D. Morris, T.C. Chen, R.D. Sudhaker, W.F. Finney, E. Widjaja, S.A. Goldstein, Bone 39, 1190 (2006)CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  1. 1.Department of Materials and Institute of Biomedical EngineeringImperial CollegeLondonUK

Personalised recommendations