Nanomechanical Cantilever Array Sensors

  • Hans Peter Lang
  • Martin Hegner
  • Christoph Gerber
Part of the Springer Handbooks book series (SHB)


Microfabricated cantilever sensors have attracted much interest in recent years as devices for the fast and reliable detection of small concentrations of molecules in air and solution. In addition to application of such sensors for gas and chemical-vapor sensing, for example as an artificial nose, they have also been employed to measure physical properties of tiny amounts of materials in miniaturized versions of conventional standard techniques such as calorimetry, thermogravimetry, weighing, photothermal spectroscopy, as well as for monitoring chemical reactions such as catalysis on small surfaces. In the past few years, the cantilever-sensor concept has been extended to biochemical applications and as an analytical device for measurements of biomaterials. Because of the label-free detection principle of cantilever sensors, their small size and scalability, this kind of device is advantageous for diagnostic applications and disease monitoring, as well as for genomics or proteomics purposes. The use of microcantilever arrays enables detection of several analytes simultaneously and solves the inherent problem of thermal drift often present when using single microcantilever sensors, as some of the cantilevers can be used as sensor cantilevers for detection, and other cantilevers serve as passivated reference cantilevers that do not exhibit affinity to the molecules to be detected.


Bovine Serum Albumine Cantilever Deflection Pentaerythritol Tetranitrate Cantilever Sensor Cantilever Array 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.





amorphous carbon


atomic force microscope


atomic force microscopy


bovine serum albumin


cantilever in cantilever


complementary metal–oxide–semiconductor


C-reactive protein








deoxyribonucleic acid






feline coronavirus






human serum albumin


independent component analysis




low-density lipoprotein






molecular recognition phase








polyethylene glycol




pentaerythritol tetranitrate


protein kinase


protein kinase inhibitor


poly(methacrylic acid)


prostate-specific antigen


position-sensitive detector


position-sensitive diode


power-spectral density


lead zirconate titanate


scanning acoustic microscopy


self-assembled monolayer


syndrome associated coronavirus


scanning force microscope


scanning force microscopy






vertical-cavity surface-emitting laser


volatile organic compound


anti-bovine serum albumin


oxidized low-density lipoprotein


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Institute of Physics, National Competence Center for Research in Nanoscale Science (NCCR) BaselUniversity of BaselBaselSwitzerland
  2. 2.School of PhysicsCRANN – The Naughton Institute Trinity College, University of DublinDublinIreland
  3. 3.Institute of Physics National Competence Center for Research in Nanoscale Science (NCCR) BaselUniversity of BaselBaselSwitzerland

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