Current Efforts to Integrate Biological Pathway Information

  • Daniel Glez-Peña
  • Rubén Domínguez
  • Gonzalo Gómez-López
  • David G. Pisano
  • Florentino Fdez-Riverola
Part of the Lecture Notes in Computer Science book series (LNCS, volume 5518)

Abstract

PathJam is a new comprehensive and freely accessible web-server application integrating scattered human pathway annotation from several public sources. The tool has been designed to be intuitive for wet-lab users providing statistical enrichment analysis of pathway annotation for a given gene list of interest. Results are displayed in several interactive and downloadable views (graphs, spread-sheets, etc.) facilitating the biological interpretation of the gene lists. Moreover, PathJam allows users to build their own gene sets files in order to use them in gene set enrichment-based analysis. Finally, a simplified version of PathJam has been also implemented as a widget and is currently available for CARGO users.

Keywords

pathway integration web-server application statistical analysis biological interpretation 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Daniel Glez-Peña
    • 1
  • Rubén Domínguez
    • 2
  • Gonzalo Gómez-López
    • 3
  • David G. Pisano
    • 3
  • Florentino Fdez-Riverola
    • 1
  1. 1.ESEI: Escuela Superior de Ingeniería InformáticaUniversity of Vigo, Edificio PolitécnicoOurenseSpain
  2. 2.Informatics Unit, Complexo Hospitalario de OurenseOurenseSpain
  3. 3.Bioinformatics Unit (UBio), Structural Biology and Biocomputing ProgrammeSpanish National Cancer Research Centre (CNIO)MadridSpain

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