The Role of KIR in Disease

  • Salim I Khakoo


Following the cloning of the killer cell immunoglobulin-like (KIR) genes in 1995 (Colonna M, Samaridis J. Science 268(5209):405–408, 1995) their population diversity has become increasingly apparent. This has spawned a plethora of disease association studies. As the KIR genes need to be considered in combination with their MHC class I ligands, this has added complexity to the analysis of these studies. KIR, and KIR:MHC class I gene combinations have been associated with viral infections, autoimmunity, transplantation and pregnancy-associated disorders. Simple rules, with which to interpret these datasets, are often difficult to find and, as our understanding of the interaction between KIR and MHC class I increases, the analysis of these datasets will become even more complex. This review attempts to summarize our current knowledge whilst indicating areas of potential further complexity.


Haematopoietic Stem Cell Transplantation Psoriatic Arthropathy Intracytoplasmic Tail Haploidentical Haematopoietic Stem Cell Transplantation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



I would like to acknowledge the assistance of Dr Lucia Possami in the construction of the figure and valuable comments on the manuscript.


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© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  1. 1.Department of HepatologyDivision of Medicine, Imperial CollegeLondonUK

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