Fertility Control pp 29-35

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 198)

Estrogen Signaling in the Regulation of Female Reproductive Functions

  • J. K. Findlay
  • S. H. Liew
  • E. R. Simpson
  • K. S. Korach
Chapter

Abstract

Estrogens influence fertility and infertility in animals. This chapter reviews the use of estrogen as a contraceptive through the regulation of its production and action. It is concluded that the use of specific agonists and antagonists of estrogen action that avoid the global and unwanted side effects of estrogen offers new potential methods of contraception.

Keywords

Aromatase Contraception Estrogen receptors Estrogens 

References

  1. Adlercreutz H (1995) Phytoestrogens:epidemiology and a possible role in cancer protection. Environ Health Perspect 103(Suppl 7):103–112PubMedCrossRefGoogle Scholar
  2. Britt KL, Findlay JK (2002) Estrogen actions in the ovary revisited. J Endocrinol 175:269–276PubMedCrossRefGoogle Scholar
  3. Britt KL, Findlay JK (2003) Regulation of the phenotype of ovarian somatic cells by estrogen. Mol Cell Endocrinol 202:11–17PubMedCrossRefGoogle Scholar
  4. Clyne CD, Speed CJ, Zhou J, Simpson ER (2002) Liver receptor homologue-1 (LRH-1) regulates expression of aromatase in preadipocytes. J Biol Chem 277:20591–20597PubMedCrossRefGoogle Scholar
  5. Couse JF, Korach KS (1999) Estrogen receptor null mice: what have we learned and where will they lead us? Endocr Rev 20:358–417PubMedCrossRefGoogle Scholar
  6. Couse JF, Hewitt SC, Korach KS (2006) Steroid receptors in the ovary and uterus. In: Neill JD (ed) Knobil and Neill: physiology of reproduction, 3rd edn. Academic Press, New York, pp 593–678CrossRefGoogle Scholar
  7. Curtis SW, Washburn TF, Sewall C, DiAugustine R, Lindzey J, Couse JF, Korach KS (1996) Physiological coupling of growth factor and steroid signaling pathways: estrogen receptor knockout mice lack estrogen-like response to EGF. Proc Natl Acad Sci USA 93:12626–12630PubMedCrossRefGoogle Scholar
  8. Diczfalusy E, Fraser IS (1998) The discovery of reproductive steroid hormones and recognition of their physiological roles. In: Fraser IS, Jansen RPS, Lobo RA, Whitehead MI (eds) Estrogens and progesterones in clinical practice. Churchill Livingstone, London, pp 3–18Google Scholar
  9. Fisher CR, Graves KH, Parlow AF, Simpson ER (1998) Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene. Proc Natl Acad Sci USA 95:6965–6970PubMedCrossRefGoogle Scholar
  10. Hall JM, Couse JF, Korach KS (2001) The multifaceted mechanisms of estradiol and estrogen receptor signaling. J Biol Chem 276:36869–36872PubMedCrossRefGoogle Scholar
  11. Hewitt SC, Deroo B, Hansen K, Collins J, Grissom S, Afshari CA, Korach KS (2003) Estrogen receptor-dependent genomic responses in the mouse uterus mirror the biphasic physiological response to estrogen. Mol Endocrinol 17:2070–2083PubMedCrossRefGoogle Scholar
  12. Hewitt SC, Harrell JC, Korach KS (2005) Lessons in estrogen biology from knockout and transgenic animals. Ann Rev Physiol 67:285–308CrossRefGoogle Scholar
  13. Hisaw FL (1947) Development of the Graafian follicle and ovulation. Physiol Rev 27:95–119PubMedGoogle Scholar
  14. Jensen EV, DeSombre ER (1973) Estrogen-receptor interaction. Science 182:126–134PubMedCrossRefGoogle Scholar
  15. Kuiper GGJM, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson JA (1996) Cloning of a novel estrogen receptor expressed in the rat prostate and ovary. Proc Natl Acad Sci USA 93:5925–5930PubMedCrossRefGoogle Scholar
  16. Levin ER (2009) G protein-coupled receptor 30: estrogen receptor or collaborator? Endocrinology 150:1563–1565PubMedCrossRefGoogle Scholar
  17. Mueller SO, Korach KS (2001) Estrogen receptors and endocrine diseases: lessons from estrogen receptor knockout mice. Curr Opin Pharmacol 1:613–619PubMedCrossRefGoogle Scholar
  18. Otto C, Fuchs I, Kauselmann G, Kern H, Zevnik B, Andreasen P, Schwarz G, Altmann H, Klewer M, Schoor M, Vonk R, Fritzemeier KH (2009) GPR30 does not mediate estrogenic responses in reproductive organs in mice. Biol Reprod 80:34–41PubMedCrossRefGoogle Scholar
  19. Pincus G, Rock J, Garcia C-R, Rice-Way E, Paniagua M, Rodriguez B, Pedras R (1958) Fertility control with oral contraception. Am J Obstet Gynecol 75:1333–1346PubMedGoogle Scholar
  20. Sharara FI, Seifer DB, Flaws JA (1998) Environmental toxins and female reproduction. Fert Steril 70:613–622CrossRefGoogle Scholar
  21. Simpson ER, Clyne CD, Rubin GL, Boon WC, Robertson KM, Britt KL, Speed CJ, Jones MEE (2002) Aromatase – a brief overview. Ann Rev Physiol 64:93–127CrossRefGoogle Scholar
  22. Swan SH (2000) Intrauterine exposure to diethylstilbestrol: long term effects on humans. APMIS 108:793–804PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • J. K. Findlay
    • 1
  • S. H. Liew
    • 1
  • E. R. Simpson
    • 1
  • K. S. Korach
    • 2
  1. 1.Prince Henry’s Institute of Medical ResearchClaytonAustralia
  2. 2.Laboratory of Reproductive and Developmental ToxicologyNIEHS/NIHDurhamUSA

Personalised recommendations