Palliativversorgung von Kindern und Jugendlichen

  • Boris Zernikow
  • Wilma Henkel

Zusammenfassung

Die Gründung des weltweit ersten Kinderhospizes „Helen House“ im britischen Oxford bedeutete 1982 eine Zäsur für die pädiatrische Palliativmedizin: Die Gründerin Frances Domenica, Nonne und Krankenschwester, wurde durch ihre Freundschaft mit dem tumorkranken Mädchen Helen zur Einrichtung eines Hospizes für Kinder und Jugendliche inspiriert. Inzwischen gibt es mehr als 30 britische Kinderhospize sowie zahlreiche Palliativeinrichtungen für Kinder in anderen Ländern. Einige Kinderhospize bieten Einrichtungen für spezielle Altersgruppen an, so das Baby-Hospiz „Zoe’s House“ in Liverpool oder die Jugendabteilung von „Acorns Walsall“ in Birmingham.

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Literatur

  1. Allington N, Vivegnis D, Gerard P (2005) Cyclic administration of pamidronate to treat osteoporosis in children with cerebral palsy or a neuromuscular disorder: a clinical study. Acta Orthop Belg 71: 91–97PubMedGoogle Scholar
  2. Anderson BJ, McKee AS, Holford NH (1997) Size, myths and the clinical pharmacokinetics of analgesia in paediatric patients. Clin Pharmacokinet 33: 313–327PubMedCrossRefGoogle Scholar
  3. Anghelescu DL, Oakes LL (2005) Ketamine use for reduction of opioid tolerance in a 5-year-old girl with end-stage abdominal neuroblastoma. J Pain Symptom Manage 30: 1–3PubMedCrossRefGoogle Scholar
  4. Association for children with Life-threatening or Terminal Conditions and their Families and the Royal College of Paediatrics and Child Health (1997) Report of a Joint Working Party of the Association for Children with Life-threatening or Terminal Conditions and their Families and the Royal College of Paediatrics and Child Health. A guide to the development of children’s palliative care services. ACT, BristolGoogle Scholar
  5. Babul N (1992) Putative role of hydromorphone metabolites in myoclonus. Pain 51: 260–261. Erratum in: Pain (1993) 52: 123PubMedCrossRefGoogle Scholar
  6. Becker G, Galandi D, Blum HE (2007) Peripherally acting opioid antagonists in the treatment of opiate-related constipation: A systematic review. J Pain Symptom Manage 34(5): 547–565PubMedCrossRefGoogle Scholar
  7. Bürgin B (1981) Das Kind, die lebensbedrohende Krankheit und der Tod. Hans Huber, BernGoogle Scholar
  8. Butkovic D, Toljan S, Mihovilovic-Novak B (2006) Experience with gabapentin for neuropathic pain in adolescents: report of five cases. Paediatr Anaesth 16: 325–329PubMedCrossRefGoogle Scholar
  9. Cepeda MS, Africano JM, Manrique AM, Fragoso W, Carr DB (2002) The combination of low dose of naloxone and morphine in PCA does not decrease opioid requirements in the postoperative period. Pain 96: 73–79PubMedCrossRefGoogle Scholar
  10. Cepeda MS, Alvarez H, Morales H, Carr DB (2004) Addition of ultralow dose naloxone to post-operative morphine PCA: unchanged analgesia and opioid requirement but decreased incidence of opioid side effects. Pain 107: 41–46PubMedCrossRefGoogle Scholar
  11. Cheung CL, Dijk M van, Green JW, Tibboel D, Anand KJ (2007) Effects of low-dose naloxone on opioid therapy in pediatric patients: a retrospective case-control study. I. Intens Care Med 33: 190–194CrossRefGoogle Scholar
  12. Collins JJ, Byrnes ME, Dunkel IJ et al. (2000) The measurement of symptoms in children with cancer. J Pain Symptom Manage 19: 363–377PubMedCrossRefGoogle Scholar
  13. Craig F, Abu-Saad Huijer H, Benini F et al. (2007) IMPaCCT: standards for paediatric palliative care in Europe. Eur J Pall Care 14(3): 109–114Google Scholar
  14. Cuer JC, Dapoigny M, Larpent JL, Lunaud B, Ferrier C, Bommelaer G (1989) Effects of buprenorphine on motor activity of the sphincter of Oddi in man. Eur J Clin Pharmacol 36: 203–204PubMedCrossRefGoogle Scholar
  15. Davies SM, Crawley EM (2008) Chronic fatigue syndrome in children aged 11 years old and younger. Arch Dis Child 99: 419–421CrossRefGoogle Scholar
  16. Department of Health and Children, Irish Hospice Foundation (2005) A palliative care needs assessment for children. Stationary Office, DublinGoogle Scholar
  17. Doyle E, Morton NS, McNicol LR (1994) Comparison of patient-controlled analgesia in children by iv and sc routes of administration. Br J Anaesth 72: 533–536PubMedCrossRefGoogle Scholar
  18. Drake R, Longworth J, Collins JJ (2004) Opioid rotation in children with cancer. J Pall Med 7: 419–422CrossRefGoogle Scholar
  19. Feudtner C, Haynes RM, Geyer JR, Neff JM, Koepsell TD (2001) Deaths attributed to pediatric complex chronic conditions: National trends and implications for supportive care services. Pediatrics 107: e99–e103PubMedCrossRefGoogle Scholar
  20. Finkel JC, Finley A, Greco C, Weisman SJ, Zeltzer L (2005) Transdermal fentanyl in the management of children with chronic severe pain: results from an international study. Cancer 104(12): 2847–2857PubMedCrossRefGoogle Scholar
  21. Francis RCE, Höhne C, Proquitté H, Kerner T (2008) Reanimation bei Kindern. Empfehlungen nach aktuellen Leitlinien. Anasthesiol Intensivmed Notfallmed Schmerzther 43: 8–17PubMedCrossRefGoogle Scholar
  22. Goldman A (2000) Symptoms and suffering at the end of life in children with cancer — correspondence. N Engl J Med 342: 1998–1999PubMedGoogle Scholar
  23. Hechler T, Blankenburg M, Friedrichsdorf S et al. (2008) Parents’ perspective on symptoms, quality of life, characteristics of death and end-of-life decisions for children dying from cancer. Klinische Pädiatrie 220: 166–174PubMedCrossRefGoogle Scholar
  24. Heubi JE, Barbacci MB, Zimmerman HJ (1998) Therapeutic misadventure with acetaminophen: hepatotoxicity after multiple doses in children. J Pediatr 132: 22–27PubMedCrossRefGoogle Scholar
  25. Hicks CL, Baeyer CL von, Spafford PA, Korlaar I van, Goodenough B (2001) The faces pain scale — Revised: Toward a common metric in pediatric pain measurement. Pain 93: 173–183PubMedCrossRefGoogle Scholar
  26. Hilden JM, Emanuel EJ, Fairdough DL et al. (2001) Attitudes and practices among pediatric oncologists regarding end-of-life care: results of the 1998 American Society of Clinical Oncology Survey. J Clin Oncol 19(1): 205–212PubMedGoogle Scholar
  27. Hunt A, Goldman A, Seers K (2004) Clinical validation of the paediatric pain profile. Develop Med Child Neurol 46(1): 9–18PubMedCrossRefGoogle Scholar
  28. Keskinbora K, Pekel AF, Aydinli I (2004) The use of gabapentin in a 12-year-old boy with cancer pain. Acta Anaesthesiol Scand 48(663): 664Google Scholar
  29. Kokki H, Rasanen I, Lasalmi M et al. (2006) Comparison of oxycodone pharmacokinetics after buccal and sublingual administration in children. Clin Pharmacokinet 45(7): 745–754PubMedCrossRefGoogle Scholar
  30. Kramer C, Tawney M (1998) A fatal overdose of transdermally administered fentanyl. JAOA 98(7): 385PubMedGoogle Scholar
  31. Kreicbergs U, Valdimarsdottir U, Onelöv E, Henter J-I, Steineck G (2004a) Talking about death with children who have severe malignant disease. N Engl J Med 351: 1175–1186PubMedCrossRefGoogle Scholar
  32. Kreicbergs U, Valdimarsdottir U, Onelöv E, Henter J-I, Steineck G (2004b) Anxiety and depression in parents 4–9 years after the loss of a child owing to malignancy: A population-based follow-up. Psychol Med 34: 1431–1441PubMedCrossRefGoogle Scholar
  33. Kreicbergs U, Valdimarsdottir U, Onelöv E, Björk O, Steineck G, Henter J-I (2005) Care-related distress. A nationwide study of parents who lost their child to cancer. J Clin Oncol 23: 9162–9171PubMedCrossRefGoogle Scholar
  34. Kurz R (2001) Decision making in extreme situations involving children: withholding or withdrawal of life supporting treatment in paediatric care. Statement of the ethics working group of the Confederation of the European Specialists of Paediatrics (CESP). Eur J Pediatr 160(4): 214–216PubMedCrossRefGoogle Scholar
  35. Lenton S, Goldman A, Southall D (2006) Development and epidemiology. In: Goldman A, Hain R, Liben S (eds) Oxford textbook of palliative care in children. Oxford University Press, Oxford, UKGoogle Scholar
  36. Liu M, Chen X (2003) Friendship networks and social, school and psychological adjustment in Chinese Junior High School students. Psychology in Schools 40(1): 5–17CrossRefGoogle Scholar
  37. Mack JW, Wolfe J, Grier HE, Cleary PD, Weeks JC (2006) Communication about prognosis between parents and physicians of children with cancer: parent preferences and the impact of prognostic information. J Clin Oncol 24(33): 5265–5270PubMedCrossRefGoogle Scholar
  38. Maunuksela EL, Korpela R, Olkkola KT (1988) Double-blind, multiple-dose comparison of buprenorphine and morphine in postoperative pain in children. Br J Anaesth 60: 48–55PubMedCrossRefGoogle Scholar
  39. Maxwell LG, Kaufmann SC, Bitzer S et al. (2005) The effects of a small-dose naloxone infusion on opioid-induced side effects and analgesia in children and adolescents treated with intravenous patient-controlled analgesia: a double-blind, prospective, randomized, controlled study. Anesth Analg 100: 953–958PubMedCrossRefGoogle Scholar
  40. Medizin-ethischer Arbeitskreis Neonatologie des Universitätspitals Zürich (Hrsg) (2002) An der Schwelle zum eigenen Leben. Lebensentscheide am Lebensanfang bei zu früh geborenen, kranken und behinderten Kindern in der Neonatologie. Bern, BerlinGoogle Scholar
  41. Michel E, Zernikow B (2006) Buprenorphineinsatz bei Kindern — eine klinisch-pharmakologische Übersicht. Schmerz 20: 40–50PubMedCrossRefGoogle Scholar
  42. Morrison W, Berkowitz I (2007) Do not attempt resuscitation orders in pediatrics. Pediatr Clin North Am 54: 757–771PubMedCrossRefGoogle Scholar
  43. Nayak S, Cunliffe M (2008) Lidocaine 5% patch for localized chronic neuropathic pain in adolescents: report of five cases. Pediatric Anesthesia 18(6): 554–558(5)PubMedCrossRefGoogle Scholar
  44. Olkkola KT, Hamunen K, Manuksela EL (1995) Clinical pharmacokinetics and pharmacodynamics of opioid analgesics in infants and children. Clin Pharmacokinet 28: 385–404PubMedCrossRefGoogle Scholar
  45. Pickering G, Loriot MA, Libert F, Eschalier A, Beaune P, Dubray C (2006) Analgesic effect of acetaminophen in humans. First evidence of a central serotonergic effect. Clin Pharmacol Ther 79: 371–379PubMedCrossRefGoogle Scholar
  46. Pokela ML, Anttilla E, Seppäla T, Olkkola KT (2005) Marked variation in oxycodone pharmacokinetics in infants. Paediatr Anaesth 15: 560–565PubMedCrossRefGoogle Scholar
  47. Pritchard M, Burghen E, Srivastava DK et al. (2008) Cancer-related symptoms most concerning to parents during the last week and last day of their child’s life. Pediatrics 121(5): e1301–e1309PubMedCrossRefGoogle Scholar
  48. Pryle BJ, Grech H, Stoddart PA, Carson R, O’Mahoney T, Reynolds F (1992) Toxicity of norpethidine in sickle cell crisis. BMJ 304(6840): 1478PubMedCrossRefGoogle Scholar
  49. Ravens-Sieberer U, Gosch A, Rajmil L et al., European KIDSCREEN Group (2005) KIDSCREEN-52 quality-of-life measure for children and adolescents. Expert Rev. Pharmacoeconomics Outcomes Res 5(3): 353–364CrossRefGoogle Scholar
  50. Reichle FM, Conzen PF (2008) Methylnaltrexone, a new peripheral μ-receptor antagonist for the prevention and treatment of opioid-induced extracerebral side effects. Cur Opin Investig Drugs 9(1): 90–100Google Scholar
  51. Rellensmann G, Hasan C (2009) Empfehlungen zum Vorgehen in Notfallsituationen. Monatsschr Kinderheilkd 157: 38–42CrossRefGoogle Scholar
  52. Ripamonti C, Groff L, Brunelli C, Polastri D, Stavrakis A, Conno F de (1998) Switching from morphine to oral methadone in treating cancer pain: what is the equianalgesic dose ratio? J Clin Oncol 16: 3216–3221PubMedGoogle Scholar
  53. Sabatowski R, Kasper SM, Radbruch L (2002) Patient-controlled analgesia with intravenous Lmethadone in a child with cancer pain refractory to high-dose morphine. J Pain Symptom Manage 23: 3–5PubMedCrossRefGoogle Scholar
  54. Sallee FR, Nesbitt L, Jackson C, Sine L, Sethuraman G (1997) Relative efficacy of haloperidol and pimozide in children and adolescents with Tourette’s disorder. Am J Psychiatry 154: 1057–1062PubMedGoogle Scholar
  55. Schechter NL, Altman A, Weisman S (1990) Report of the Consensus Conference on the Management of Pain in Childhood Cancer. Pediatrics 5(Suppl 2): 813–834Google Scholar
  56. Shannon M, Berde CB (1989) Pharmacologic management of pain in children and adolescents. Pediatr Clin North Am 36: 855–871PubMedGoogle Scholar
  57. Sharar SR, Bratton SL, Garrougher MN et al. (1998) A comparison of oral transmucosal fentanyl citrate and oral hydromorphone for inpatient pediatric burn wound care analgesia. J Burn Care Rehabil 19: 516–521PubMedCrossRefGoogle Scholar
  58. Siden HB (2008) Haloperidol as a palliative anti-emetic in a toddler: An evidence base challenge. J Pain Symptom Manage 35(3): 235–238PubMedCrossRefGoogle Scholar
  59. Sirkiä K, Saarinen UM, Ahlgren B, Hovi L (1997) Terminal care of the child with cancer at home. Acta Paediatr 86(10): 1125–1130PubMedCrossRefGoogle Scholar
  60. Sirkiä K, Hovi L, Pouttu J, Saarinen-Pihkala UM (1998) Pain medication during terminal care of children with cancer. J Pain Symptom Manage 15: 220–226PubMedCrossRefGoogle Scholar
  61. Smith ER (2000) Research design. In: Reis HT, Judd CM (eds) Handbook of research methods in social and personality psychology (pp 17–39). University Press, CambridgeGoogle Scholar
  62. Staritz M (1988) Pharmacology of the sphincter of Oddi. Endoscopy 20(Suppl. 1 ): 171–174PubMedCrossRefGoogle Scholar
  63. Theunissen JM, Hoogerbrugge PM, Achterberg T van, Prins JB, Vernooij-Dassen MJ, Ende CH van den (2007) Symptoms in the palliative phase of children with cancer. Pediatr Blood Cancer 49: 160–165PubMedCrossRefGoogle Scholar
  64. Thomas J, Karver S, Cooney GA et al. (2008) Methylnaltrexone for opioid-induced constipation in advanced illness. N Engl J Med 358(22): 2332PubMedCrossRefGoogle Scholar
  65. Thwaites D, McCann S, Broderick P (2004) Hydromorphone neuroexcitation. J Pall Med 7: 545–550CrossRefGoogle Scholar
  66. Tsui BC, Davies D, Desai S, Malherbe S (2004) Intravenous ketamine infusion as an adjuvant to morphine in a 2-year-old with severe cancer pain from metastatic neuroblastoma. J Pediatr Hematol Oncol 26: 678–680PubMedCrossRefGoogle Scholar
  67. Voorthuizen T van, Helmers JH, Tjoeng MM, Otten MH (2000) Meperidine (pethidine) outdated as analgesic in acute pancreatitis. Ned Tijdschr Geneeskd 144(14): 656–658PubMedGoogle Scholar
  68. Watterson G, Howard R, Goldmann A (2004) Peripheral opioids in inflammatory pain. Arch Dis Child 89: 679–681PubMedCrossRefGoogle Scholar
  69. Wilens TE, Biederman J, Baldessarini RJ et al. (1996) Cardiovascular effects of therapeutic doses of tricyclic antidepressants in children and adolescents. J Am Acad Child Adolesc Psychiatry 35: 1491–1501PubMedCrossRefGoogle Scholar
  70. Wolfe J, Grier HE, Klar N (2000) Symptoms and suffering at the end of life in children with cancer. N Engl J Med 342: 326–333PubMedCrossRefGoogle Scholar
  71. Wolfe J, Hammel JF, Edwards KE et al. (2008) Easing of suffering in children with cancer at the end of life: Is care changing? J Clin Oncol 26(10): 1717PubMedCrossRefGoogle Scholar
  72. World Health Organisation (1998) Cancer pain relief and palliative care in children. Geneva: World Health Organisation in collaboration with the International Association for the Study of PainGoogle Scholar
  73. Wright AW, Nocente ML, Smith MT (1998) Hydromorphone-3-glucuronide: biochemical synthesis and preliminary pharmacological evaluation. Life Sci 63:401–411PubMedCrossRefGoogle Scholar
  74. Wright J, Vaze P, Russell G et al. (2001) Seasonal aspects of weight-for-age in young children in Zimbabwe. Public Health Nutrition 4(3): 757–764PubMedCrossRefGoogle Scholar
  75. Zanette G, Manani G, Giusti F, Pittoni G, Ori C (1996) Respiratory depression following administration of low dose buprenorphine as postoperative analgesic after fentanyl balanced anaesthesia. Paediatr Anaesth 6: 419–422PubMedCrossRefGoogle Scholar
  76. Zernikow B (2005) Sterbende Kinder und ihre Eltern versorgen — Hilft uns das Wissen um die kindlichen Vorstellungen von Tod weiter? Neuropädiatrie 4: 22–26Google Scholar
  77. Zernikow B (2008) Palliativversorgung von Kindern, Jugendlichen und jungen Erwachsenen. Springer, BerlinCrossRefGoogle Scholar
  78. Zernikow B, Dietz B (2003) Schmerzerkennung,-messung und-therapie bei Kindern mit kognitiver und körperlicher Behinderung. Neuropädiatrie in Klinik und Praxis 2: 12–17Google Scholar
  79. Zernikow B, Lindena G (2001) Long acting morphine for pain control in paediatric oncology. Pediatr Oncol 36: 451–458CrossRefGoogle Scholar
  80. Zernikow B, Nauck F (2008) Kinderpalliativmedizin: Kindern ein gutes Sterben ermöglichen. Dt Ärztebl 105(28–29): 511–522Google Scholar
  81. Zernikow B, Grießinger N, Fengler R (1999) Praktische Schmerztherapie in der Kinderonkologie: Empfehlungen der Qualitätssicherungsgruppe der Gesellschaft für Pädiatrische Onkologie und Hämatologie (GPOH). Monatsschr Kinderheilkd 147: 438–456CrossRefGoogle Scholar
  82. Zernikow B, Bauer A, Andler W (2001) Schmerztherapie in der pädiatrischen Onkologie — Eine Bestandsaufnahme. Schmerz 16: 140–149CrossRefGoogle Scholar
  83. Zernikow B, Friedrichsdorf S, Wamsler C, Michel E. (2002) Schmerztherapie und palliative Versorgung krebskranker Kinder (Deutsche Ausgabe der WHO-Empfehlungen „Cancer pain relief and palliative care in children“) Vestische Kinderklinik Datteln — Universität Witten/ HerdeckeGoogle Scholar
  84. Zernikow B, Schiessl C, Wamsler C, Grießinger N, Sittl R (2005) Opioidtherapie chronischer Schmerzen bei Kindern — Fallbesprechungen. Schmerz 19: 418–425PubMedCrossRefGoogle Scholar
  85. Zernikow B, Hasan C, Gordon D, Hechler T, Hübner B, Michel E (2008) Stop the pain! A nationwide quality improvement programme in paediatric oncology pain control. Eur J Pain 12: 819–833PubMedCrossRefGoogle Scholar
  86. Zisook S, Lyons L (1988) Grief and relationship to the deceased. Int J Fam Psych 9: 135–146Google Scholar

Copyright information

© Springer Medizin Verlag Heidelberg 2009

Authors and Affiliations

  • Boris Zernikow
    • 1
  • Wilma Henkel
    • 1
  1. 1.Vodafone Stiftungsinstitut für Kinderschmerztherapie und Pädiatrische PalliativmedizinVestische Kinder- und Jugendklinik Universität Witten/HerdeckeDatteln

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