Genotype and Haplotype Reconstruction from Low-Coverage Short Sequencing Reads

  • Ion Măndoiu
Part of the Lecture Notes in Computer Science book series (LNCS, volume 5462)


Recent advances in high-throughput sequencing (HTS) technologies have led to orders of magnitude higher throughput compared to classic Sanger sequencing (see [3] for a review). Coupled with continuously decreasing sequencing costs, HTS data provides opportunities to study genome structure, function, and evolution at an unprecedented scale, and is profoundly transforming biomedical research.


Haplotype Sequence Paternal Chromosome Haplotype Reconstruction Unprecedented Scale Common Human Disease 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Ion Măndoiu
    • 1
  1. 1.Department of Computer Science & EngineeringUniversity of ConnecticutStorrsUSA

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