Genotype and Haplotype Reconstruction from Low-Coverage Short Sequencing Reads

  • Ion Măndoiu
Part of the Lecture Notes in Computer Science book series (LNCS, volume 5462)

Abstract

Recent advances in high-throughput sequencing (HTS) technologies have led to orders of magnitude higher throughput compared to classic Sanger sequencing (see [3] for a review). Coupled with continuously decreasing sequencing costs, HTS data provides opportunities to study genome structure, function, and evolution at an unprecedented scale, and is profoundly transforming biomedical research.

Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Ion Măndoiu
    • 1
  1. 1.Department of Computer Science & EngineeringUniversity of ConnecticutStorrsUSA

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