Noncoding RNAs in the Development, Function and Pathologies of the Central Nervous System
Noncoding RNAs (ncRNAs) are now recognized as important components of regulatory networks governing gene expression in all organisms. In mammals ncRNAs have been shown to regulate many key processes associated with the development and maintenance of specific gene expression profiles. In the nervous system many various classes of ncRNAs play a role in neural cells differentiation and activity. Aberrant expression of noncoding transcripts in the cells of the nervous system is often associated with severe disorders involving neurodegenerative diseases, psychiatric conditions and cancer.
KeywordsNoncoding RNAs Imprint Gene Antisense Transcript Angelman Syndrome Amyloid Precursor Protein Gene
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