Harmony Search in Therapeutic Medical Physics

  • Aditya Panchal
Part of the Studies in Computational Intelligence book series (SCI, volume 191)


Medical physics is a branch of physics that concerns the application of radiation for therapeutic and diagnostic use in medicine. In therapeutic medical physics, ionizing radiation is used to treat patients afflicted with cancer. The main goal in radiotherapy is to deliver a high amount of radiation dose to cancer cells while sparing surrounding organs. The process begins with radiation treatment planning that requires optimization of radioisotope placement or radiation beam intensities. Prior optimization algorithms, such as genetic algorithm and simulated annealing, have been widely discussed in medical physics literature. However, Harmony Search has shown to be a superior optimization algorithm based on the results in other scientific fields. Thus, this study investigated high dose-rate prostate brachytherapy optimization using Harmony Search. Results showed that the algorithm is significantly faster than genetic algorithm and that rapid planning allows improved patient care in medical physics.


Medical Physics Radiation Oncology Brachytherapy Optimization Harmony Search 


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  1. 1.
    Schreibmann, E., Lahanas, M., Xing, L., Baltas, E.: Multiobjective evolutionary optimization of the number of beams, their orientations and weights for intensity-modulated radiation therapy. Phys. Med. Biol. 49, 747–770 (2004)CrossRefGoogle Scholar
  2. 2.
    Lessard, E., Pouliot, J.: Inverse planning anatomy-based dose optimization for HDR-brachytherapy of the prostate using fast simulated annealing algorithm and dedicated objective function. Medical Physics 28, 773–779 (2001)CrossRefGoogle Scholar
  3. 3.
    Jozsef, G., Streeter, O.E., Astrahan, M.A.: The use of linear programming in optimization of HDR implant dose distributions. Medical Physics 30, 751–760 (2003)CrossRefGoogle Scholar
  4. 4.
    Geem, Z.W., Kim, J.H., Loganathan, G.V.: A new heuristic optimization algorithm: harmony search. Simulation 76, 60–68 (2001)CrossRefGoogle Scholar
  5. 5.
    Kim, J.H., Geem, Z.W., Kim, E.S.: Parameter estimation of the non-linear Muskingum model using harmony search. Journal of the American Water Resources Association 37, 1131–1138 (2001)CrossRefGoogle Scholar
  6. 6.
    Geem, Z.W., Kim, J.H., Loganathan, G.V.: Harmony search optimization: application to pipe network design. International Journal of Modeling & Simulation 22, 125–133 (2002)Google Scholar
  7. 7.
    Lee, K.S., Geem, Z.W.: A new structural optimization method based on the harmony search algorithm. Computers and Structures 82, 781–798 (2004)CrossRefGoogle Scholar
  8. 8.
    Geem, Z.W., Lee, K.S., Park, Y.: Application of harmony search to vehicle routing. American Journal of Applied Sciences 2, 1552–1557 (2005)CrossRefGoogle Scholar
  9. 9.
    Geem, Z.W., Choi, J.: Music composition using harmony search algorithm. In: Giacobini, M. (ed.) EvoWorkshops 2007. LNCS, vol. 4448, pp. 593–600. Springer, Heidelberg (2007)Google Scholar
  10. 10.
    Chen, G.T., Pelizzari, C.A., Spelbring, D.R., Awan, A.: Evaluation of treatment plans using dose volume histograms. Front Radiat. Ther. Oncol. 21, 44–55 (1987)Google Scholar
  11. 11.
    Chen, Y., Boyer, A.L., Xing, L.: A dose-volume histogram based optimization algorithm for ultrasound guided prostate implants. Medical Physics 27, 2286–2292 (2000)CrossRefGoogle Scholar
  12. 12.
    Kemmerer, T., Lahanas, M., Baltas, D., Zamboglou, N.: Dose-volume histograms computation comparisons using conventional methods and optimized fast Fourier transforms algorithms for brachytherapy. Medical Physics 27, 2343–2356Google Scholar
  13. 13.
    Karouzakis, K., Lahanas, M., Milickovic, N., Giannouli, S., Baltas, D., Zamboglou, N.: Brachytherapy dose–volume histogram computations using optimized stratified sampling methods. Medical Physics 29, 424–432 (2002)CrossRefGoogle Scholar
  14. 14.
    Hsu, I.C., Shinohara, K., Pouliot, J., Purdy, J., Michaelski, J., Ibbot, G.: RTOG protocol 0321 - phase II trial of combined high dose rate brachytherapy and external beam radiotherapy for adenocarcinoma of the prostate (2006) (accessed October 31, 2008),
  15. 15.
    Csendes, T., Ratz, D.: Subdivision direction selection in interval methods for global optimization. SIAM Journal on Numerical Analysis 34, 922–938 (1997)zbMATHCrossRefMathSciNetGoogle Scholar
  16. 16.
    Otto, K.: Volumetric modulated arc therapy: IMRT in a single gantry arc. Medical Physics 35, 310–317 (2008)CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Aditya Panchal
    • 1
  1. 1.Department of Medical PhysicsAdvocate Lutheran General HospitalUSA

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