Microdevice for Trapping Circulating Tumor Cells for Cancer Diagnostics

  • S. J. Tan
  • L. Yobas
  • G. Y. H. Lee
  • C. N. Ong
  • C. T. Lim
Part of the IFMBE Proceedings book series (IFMBE, volume 23)

Abstract

Cancer metastasis is the main attribute to cancerrelated deaths and early detection is one of the most effective means to treat the disease. Spreading of cancer to distant sites is achieved usually through the circulatory system and the number of circulating tumor cells (CTCs) in peripheral blood is strongly associated to cancer development. Thus detecting CTCs in blood samples will be helpful in identifying susceptible subjects. Here, we propose a label-free technique to isolate these cancerous cells from blood. Using cancer cells spiked in blood samples, isolation efficiency of at least 80% were obtained with high isolation purity. The microdevice also preserved the integrity of the isolated cells to allow further studies to be done on these cells. These results showed a potential effective microdevice for CTCs studies and possible clinical application.

Keywords

Cell Isolation Microfluidics Circulating Tumor Cells Cancer Metastasis Computational Fluid Dynamics (CFD) 

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Copyright information

© International Federation of Medical and Biological Engineering 2009

Authors and Affiliations

  • S. J. Tan
    • 1
    • 2
  • L. Yobas
    • 1
  • G. Y. H. Lee
    • 3
  • C. N. Ong
    • 4
  • C. T. Lim
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
  1. 1.A*STARInstitute of MicroelectronicsSingapore
  2. 2.NUS Graduate School for Integrative Sciences and EngineeringNational University of SingaporeSingapore
  3. 3.Singapore-MIT AllianceSingapore
  4. 4.Life Sciences InstituteNational University of SingaporeSingapore
  5. 5.Department of Mechanical EngineeringNational University of SingaporeSingapore
  6. 6.NanoBiomechanics Laboratory, Division of BioengineeringNational University of SingaporeSingaporeSingapore

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