Vaccines for Pandemic Influenza pp 109-132

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 333)

Live Attenuated Vaccines for Pandemic Influenza

Chapter

Abstract

In this chapter, we will review the development of and clinical experience with the currently licensed seasonal live attenuated influenza vaccines (LAIV) and preclinical studies of H5, H7, and H9 live attenuated pandemic influenza vaccine candidates. Vectored vaccine approaches will not be reviewed in this chapter. Experience with seasonal influenza vaccination has demonstrated the safety and efficacy of LAIV in both children and adults; moreover, cross-protection among antigenically distinct viruses within the same subtype may be induced by LAIV. While clinical studies and further characterization of the immunologic response to avian influenza viruses are still needed, the experience with seasonal LAIV underscores the potential of live attenuated vaccines to play an important role in the event of a pandemic.

Keywords

live attenuated influenza vaccines pandemic Plasmid-based reverse genetics techniques 

Abbreviations

AI

Avian influenza

AIV

Avian influenza virus

ca

Cold-adapted

EID50

50% Egg infectious dose

HA

Hemagglutinin

HAI

Hemagglutination inhibition

HID50

50% Human infectious dose

i.n.

Intranasal

i.m.

Intramuscular

LAIV

Live attenuated influenza vaccine

LD50

50% Lethal dose

MDV

Master donor virus

MID50

50% Mouse infectious dose

NA

Neuraminidase

PFU

Plaque-forming units

TCID50

50% Tissue culture infectious dose

TIV

Trivalent inactivated vaccine

ts

Temperature-sensitive

wt

Wild-type

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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  1. 1.NIAID, NIHBethesdaUSA
  2. 2.Laboratory of Infectious DiseasesNIAID, NIHBethesdaUSA

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