Preparation and Characterization of Dextran-Covered Fe3O4 Nanoparticles for Magnetic Particle Imaging
Magnetic particle imaging (MPI) is a recently proposed method for the visualization of the spatial distribution of iron-oxide nanoparticles. The principle is based on the superparamagnetic nature of Fe3O4 particles (SPIOs). Iron-oxide particles covered with dextran and derivates are widely used as contrast agents in MRI imaging. However, besides the spatial bio-distribution the image quality of the magnetic-particle imaging concept is determined by the particle diameter as well. Moreover, it is the particle size distribution that affects the measured magnetization response within MPI. Therefore, the spectral analysis of the synthesized nanoparticles is an essential assay step for particle validation.
Keywordsmagnetic nanoparticles SPIO paramagetism magnetic particle imaging photon cross-correlation
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- 2.Lonnemark M, Hemmigsson A, Carlsten J (1988) Superparamagnetic particles as a MRI contrast agent for the gastrointestinal tract. Acta Radiol 29:599–602Google Scholar
- 4.Rozenman Y, Zou X (1989) Cardiovascular MRI with ferrite particles: The utility of a superparamagnetic contrast agent. Abstract SMRM Amsterdam, 1:353Google Scholar
- 10.Widder D J, Edelman R R, Grief W L, Monda L (1987) Magnetite albumin suspension: A superparamagnetic oral MR contrast agent. AJR 149:839–843Google Scholar
- 12.Witt W, Aberle L, Geers H (2003) Measurement of particle size and stability of nanoparticels in opaque suspensions and emulsions with photon cross correlation spectroscopy. Particulate Systems Analysis, Harrogate, UKGoogle Scholar
- 13.Biederer S, Sattel T, Knopp T, Lüdtke-Buzug K, Gleich B, Weizenegger J, Borgert J, Buzug T M (2008) A Spectrometer for Magnetic Particle Imaging. 4th European Congress for Medical and Biomedical Engineering in pressGoogle Scholar
- 14.Demirer M (2006) Controlled synthesis of superparamagnetic iron oxide nanoparticles in the presence of poly(acrylic acid). Master thesis, Koc UniversityGoogle Scholar
- 16.Groman E V, Josephson L, Lewis J M (1989) Biologically degradable superparamagnetic materials for use in clinical applications. US 4827945Google Scholar