Abstract
Stents are largely used to counteract and relieve duct or vessel obstructions. The purpose of this current study is to select a biodegradable, antibacterial and environmentally friendly material to design and prepare a stent to counteract anastomotic leakage following gastrointestinal surgery. A precast moulding process was used to prepare medium molecular weight chitosan scaffolds, for stent design. Chitosan samples were prepared by opening the bonds of the material in acetic acid, moulding the material and curing the mouldings in sodium hydroxide. The film like mouldings were wound around a metallic rod, fixing the layers together with un-cured chitosan and subsequently curing the chitosan layers together with sodium hydroxide producing the stent like shape. Tensile and tensile creep strength of the chitosan material was investigated. This research concluded that chitosan can be moulded into a stent like geometry. Mechanical testing showed the tensile and tensile creep strength were repeatable and could be predetermined. This indicates that chitosan is a suitable material for the further development of a biodegradable stent designed to counteract gastrointestinal leakage.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Sina Dorudi, Robert JC Steele & Colin S. McArdle, (2002) surgery for colorectal cancer, British medical bulletin 64: 101–118.
CRC Cancerstats, (1999) London: Cancer research campaign.
Global cancer facts and figures (2007), American cancer society.
B. J. Moran & R. J. Heard, (2000) risk factors for and management of anastomotic leakage in rectal surgery, Blackwell Science Ltd. Colorectal Disease, 3, 135–137.
Anthony S. Mee, (2000) expandable metal stents in malignant colorectal obstruction, British medical journal 321(7261): 584–585.
Chien Yuh Yeh et al, (2005) pelvic drainage and other risk factors for leakage after elective anterior resection in rectal cancer patients, Annals of surgery, 241(1), 9–13.
Michael Lim et al, 2005 clinical and subclinical leaks after low colorectal anastomosis, Disease of the colon and rectum 49: 1611–1619.
Hok-Kwok Choi et al, (2006) leakage after resection and intraperitonal anastomosis for colorectal malignancy, Disease of the colon and rectum 49: 1719–1725.
Iruru Maetani et al, (2005) technical tips for stent placement in the proximal colon using knitted esophageal stent, Digestive endoscopy 17, 334–337.
S. Athreya et al, (2006) colorectal stenting for colonic obstructions, European journal of radiology 60,1: 91–94.
Thomas Scileppi et al, (2005) the use of a Polyflex coated esophageal stent to assist in the closure of a colonic anastomotic leak, gastrointestinal endoscopy 62,4: 643–645.
Makoto Obayashi et al, (2002) endoscopic placement of a metallic stent for colonic stricture resulting from carcinoma located at the splenic flexure, digestive endoscopy 14: 123–127.
A. Lauto et al, (2001) self-expandable chitosan stent: design and preparation, Elsevier, biomaterials 22, 1869–1874.
Yawo-Kuo et al, 2005 Preparation of novel chitosan scaffolds by electrochemical process, Elsevier, carbohydrate polymers 62, 113–119.
James M. Pachence et al, (2000) biodegradable polymers, principles of tissue engineering, 2nd edition, chapter 22, 265–266.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Rothwell, R.A., Thomson, G.A., Pridham, M.S. (2009). Stent Design for Gastrointestinal Leakage. In: Vander Sloten, J., Verdonck, P., Nyssen, M., Haueisen, J. (eds) 4th European Conference of the International Federation for Medical and Biological Engineering. IFMBE Proceedings, vol 22. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-89208-3_518
Download citation
DOI: https://doi.org/10.1007/978-3-540-89208-3_518
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-89207-6
Online ISBN: 978-3-540-89208-3
eBook Packages: EngineeringEngineering (R0)