Gene Selection for Microarray Data by a LDA-Based Genetic Algorithm

  • Edmundo Bonilla Huerta
  • Béatrice Duval
  • Jin-Kao Hao
Part of the Lecture Notes in Computer Science book series (LNCS, volume 5265)

Abstract

Gene selection aims at identifying a (small) subset of informative genes from the initial data in order to obtain high predictive accuracy. This paper introduces a new wrapper approach to this difficult task where a Genetic Algorithm (GA) is combined with Fisher’s Linear Discriminant Analysis (LDA). This LDA-based GA algorithm has the major characteristic that the GA uses not only a LDA classifier in its fitness function, but also LDA’s discriminant coefficients in its dedicated crossover and mutation operators. The proposed algorithm is assessed on a set of seven well-known datasets from the literature and compared with 16 state-of-art algorithms. The results show that our LDA-based GA obtains globally high classification accuracies (81%-100%) with a very small number of genes (2-19).

Keywords

Linear discriminant analysis genetic algorithm gene selection classification wrapper 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • Edmundo Bonilla Huerta
    • 1
  • Béatrice Duval
    • 1
  • Jin-Kao Hao
    • 1
  1. 1.LERIAUniversité d’AngersAngersFrance

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