Modeling Synchronization Loss in Large-Scale Brain Dynamics
We implement a model of the large-scale dynamics of the brain, and analyze the effect of both short- and long-range connectivity degradation on its coordinated activity, with the ultimate goal of comparing the structural and functional characteristics of neurodegenerative diseases such as Alzheimer’s. A preliminary comparison between the results obtained with the model and the activity measured in patients diagnosed with mild cognitive impairment (a precursor of Alzheimer’s disease) and healthy elderly controls is shown.
KeywordsMild Cognitive Impairment Healthy Elderly Subject Cortical Column Neighboring Voxels Neural Mass Model
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- 9.Thompson, P.M., Hayashi, K.M., de Zubicaray, G., Janke, A.L., Rose, S.E., Semple, J., Herman, D., Hong, M.S., Dittmer, S.S., Doddrell, D.M., Toga, A.W.: Dynamics of gray matter loss in Alzheimer’s disease. Journal of Neuroscience 23(3), 994–1005 (2003)Google Scholar
- 11.Cruz-Vadell, A., Atienza, M., Gil-Neciga, E., Gomez-Herrero, G., Rodriguez-Romero, R., Garcia-Solis, D., Cantero, J.L.: Functional integrity of thalamocortical circuits differentiates normal aging from mild cognitive impairment (sumbitted, 2008)Google Scholar