Probabilistic Anatomo-Functional Parcellation of the Cortex: How Many Regions?

  • Alan Tucholka
  • Bertrand Thirion
  • Matthieu Perrot
  • Philippe Pinel
  • Jean-François Mangin
  • Jean-Baptiste Poline
Part of the Lecture Notes in Computer Science book series (LNCS, volume 5242)


Understanding brain structure and function entails the inclusion of anatomical and functional information in a common space, in order to study how these different informations relate to each other in a population of subjects. In this paper, we revisit the parcellation model and explicitly combine anatomical features, i.e. a segmentation of the cortex into gyri, with a functional information under the form of several cortical maps, which are used to further subdivide the gyri into functionally consistent regions. A probabilistic model is introduced, and the parcellation model is estimated using a Variational Bayes approach. The number of regions in the model is validated based on cross-validation. It is found that about 250 patches of cortex can be delineated both in the left and right hemisphere based on this procedure.


Gaussian Mixture Model Functional Information fMRI Data Cortical Surface Replicator Dynamic 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • Alan Tucholka
    • 1
    • 2
  • Bertrand Thirion
    • 2
  • Matthieu Perrot
    • 1
  • Philippe Pinel
    • 3
  • Jean-François Mangin
    • 1
  • Jean-Baptiste Poline
    • 1
  1. 1.CEA SaclayNeurospin/LNAO, Bât 145Gif-sur-Yvette cedexFrance
  2. 2.INRIA Saclay-Île-de-FranceParietalFrance
  3. 3.INSERM UNICOG, NeurospinParisFrance

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