Probabilistic Anatomo-Functional Parcellation of the Cortex: How Many Regions?
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- Tucholka A., Thirion B., Perrot M., Pinel P., Mangin JF., Poline JB. (2008) Probabilistic Anatomo-Functional Parcellation of the Cortex: How Many Regions?. In: Metaxas D., Axel L., Fichtinger G., Székely G. (eds) Medical Image Computing and Computer-Assisted Intervention – MICCAI 2008. MICCAI 2008. Lecture Notes in Computer Science, vol 5242. Springer, Berlin, Heidelberg
Understanding brain structure and function entails the inclusion of anatomical and functional information in a common space, in order to study how these different informations relate to each other in a population of subjects. In this paper, we revisit the parcellation model and explicitly combine anatomical features, i.e. a segmentation of the cortex into gyri, with a functional information under the form of several cortical maps, which are used to further subdivide the gyri into functionally consistent regions. A probabilistic model is introduced, and the parcellation model is estimated using a Variational Bayes approach. The number of regions in the model is validated based on cross-validation. It is found that about 250 patches of cortex can be delineated both in the left and right hemisphere based on this procedure.
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