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Taxadiene synthase

Part of the Springer Handbook of Enzymes book series (HDBKENZYMES, volume S7)

Keywords

Breast Cancer Reaction Type Cyclization Reaction Commit Step Farnesyl Diphosphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Williams, D.C.; Carroll, B.J.; Jin, Q.; Rithner, C.D.; Lenger, S.R.; Floss, H.G.; Coates, R.M.; Williams, R.M.; Croteau, R.: Intramolecular proton transfer in the cyclization of geranylgeranyl diphosphate to the taxadiene precursor of taxol catalyzed by recombinant taxadiene synthase. Chem. Biol., 7, 969–977 (2000)CrossRefPubMedGoogle Scholar
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    Williams, D.C.; Wildung, M.R.; Jin, A.Q.; Dalal, D.; Oliver, J.S.; Coates, R.M.; Croteau, R.: Heterologous xpression and characterization of a “Pseudomature” form of taxadiene synthase involved in paclitaxel (taxol) biosynthesis and evaluation of a potential intermediate and inhibitors of the multistep diterpene cyclization reaction. Arch. Biochem. Biophys., 379, 137–146 (2000)CrossRefPubMedGoogle Scholar
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    Huang, Q.; Roessner, C.A.; Croteau, R.; Scott, A.I.: Engineering Escherichia coli for the synthesis of taxadiene, a key intermediate in the biosynthesis of taxol. Bioorg. Med. Chem., 9, 2237–2242 (2001)CrossRefPubMedGoogle Scholar
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    Huang, Q.; Williams, H.J.; Roessner, C.A.; Scott, A.I.: Sesquiterpenes produced by truncated taxadiene synthase. Tetrahedron Lett., 41, 9701–9704 (2000)CrossRefGoogle Scholar
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    Jin, Y.; Williams, D.C.; Croteau, R.; Coates, R.M.: Taxadiene synthase-catalyzed cyclization of 6-fluorogeranylgeranyl diphosphate to 7-fluoroverticillenes. J. Am. Chem. Soc., 127, 7834–7842 (2005)CrossRefPubMedGoogle Scholar
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    Jin, Q.; Williams, D.C.; Hezari, M.; Croteau, R.; Coates, R.M.: Stereochemistry of the macrocyclization and elimination steps in taxadiene biosynthesis through deuterium labeling. J. Org. Chem., 70, 4667–4675 (2005)CrossRefPubMedGoogle Scholar
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    Chow, S.Y.; Williams, H.J.; Huang, Q.; Nanda, S.; Scott, A.I.: Studies on taxadiene synthase: interception of the cyclization cascade at the isocembrene stage with GGPP analogues. J. Org. Chem., 70, 9997–10003 (2005)CrossRefPubMedGoogle Scholar

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