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Copalyl diphosphate synthase

Part of the Springer Handbook of Enzymes book series (HDBKENZYMES, volume S7)

Keywords

Reaction Type Abietic Acid Farnesyl Diphosphate Diffusive Transfer Geranylgeranyl Pyrophosphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. [1]
    LeFever, R.E.; Vogel, B.S.; Croteau, R.: Diterpenoid resin acid biosynthesis in conifers: enzymic cyclization of geranylgeranyl pyrophosphate to abietadiene, the precursor of abietic acid. Arch. Biochem. Biophys., 313, 139–149 (1994)CrossRefGoogle Scholar
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    Ravn, M.M.; Coates, R.M.; Jetter, R.; Croteau, R.B.: Stereospecific intramolecular proton transfer in the cyclization of geranylgeranyl diphosphate to (-)-abietadiene catalyzed by recombinant cyclase from grand fir (Abies grandis). Chem. Commun., 1998, 21–22 (1998)CrossRefGoogle Scholar
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    Ravn, M.M.; Coates, R.M.; Flory, J.E.; Peters, R.J.; Croteau, R.: Stereochemistry of the cyclization-rearrangement of (+)-copalyl diphosphate to (-)-abietadiene catalyzed by recombinant abietadiene synthase from Abies grandis. Org. Lett., 2, 573–576 (2000)CrossRefPubMedGoogle Scholar
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    Peters, R.J.; Flory, J.E.; Jetter, R.; Ravn, M.M.; Lee, H.J.; Coates, R.M.; Croteau, R.B.: Abietadiene synthase from grand fir (Abies grandis): characterization and mechanism of action of the “pseudomature” recombinant enzyme. Biochemistry, 39, 15592–15602 (2000)CrossRefPubMedGoogle Scholar
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    Peters, R.J.; Ravn, M.M.; Coates, R.M.; Croteau, R.B.: Bifunctional abietadiene synthase: Free diffusive transfer of the (+)-copalyl diphosphate intermediate between two distinct active sites. J. Am. Chem. Soc., 123, 8974–8978 (2001)CrossRefPubMedGoogle Scholar
  6. [6]
    Peters, R.J.; Croteau, R.B.: Abietadiene synthase catalysis: conserved residues involved in protonation-initiated cyclization of geranylgeranyl diphosphate to (+)-copalyl diphosphate. Biochemistry, 41, 1836–1842 (2002)CrossRefPubMedGoogle Scholar
  7. [7]
    Peters, R.J.; Croteau, R.B.: Abietadiene synthase catalysis: mutational analysis of a prenyl diphosphate ionization-initiated cyclization and rearrangement. Proc. Natl. Acad. Sci. USA, 99, 580–584 (2002)CrossRefPubMedGoogle Scholar
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    Ravn, M.M.; Peters, R.J.; Coates, R.M.; Croteau, R.: Mechanism of abietadiene synthase catalysis: stereochemistry and stabilization of the cryptic pimarenyl carbocation intermediates. J. Am. Chem. Soc., 124, 6998–7006 (2002)CrossRefPubMedGoogle Scholar
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    Peters, R.J.; Carter, O.A.; Zhang, Y.; Matthews, B.W.; Croteau, R.B.: Bifunctional abietadiene synthase: mutual structural dependence of the active sites for protonation-initiated and ionization-initiated cyclizations. Biochemistry, 42, 2700–2707 (2003)CrossRefPubMedGoogle Scholar
  10. [10]
    Smith, M.W.; Yamaguchi, S.; Ait-Ali, T.; Kamiya, Y.: The first step of gibberellin biosynthesis in pumpkin is catalyzed by at least two copalyl diphosphate synthases encoded by differentially regulated genes. Plant Physiol., 118, 1411–1419 (1998)CrossRefPubMedGoogle Scholar
  11. [11]
    Tudzynski, B.; Kawaide, H.; Kamiya, Y.: Gibberellin biosynthesis in Gibberella fujikuroi: cloning and characterization of the copalyl diphosphate synthase gene. Curr. Genet., 34, 234–240 (1998)CrossRefPubMedGoogle Scholar

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